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Publication list

publication_uri type publication_title year doi pmid journal_uri
http://vivo.scripps.edu/individual/e2n227157 AcademicArticle Telomere length heterogeneity in ALT cells is maintained by PML-dependent localization of the BTR complex to telomeres 2020 10.1101/gad.333963.119 32217664 http://vivo.scripps.edu/individual/endnote235793
http://vivo.scripps.edu/individual/e2n144690 AcademicArticle New codons for efficient production of unnatural proteins in a semisynthetic organism 2020 10.1038/s41589-020-0507-z 32251411 http://vivo.scripps.edu/individual/endnote16708
http://vivo.scripps.edu/individual/e2n373482 AcademicArticle Mapping RNAPII CTD phosphorylation reveals that the identity and modification of seventh heptad residues direct Tyr1 phosphorylation 2019 10.1021/acschembio.9b00610 31553563 http://vivo.scripps.edu/individual/endnote153903
http://vivo.scripps.edu/individual/e2n210636 AcademicArticle Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb 2019 10.7554/eLife.48725 31385803 http://vivo.scripps.edu/individual/e2n358763
http://vivo.scripps.edu/individual/e2n14148 AcademicArticle Identification of the Formycin A biosynthetic gene cluster from streptomyces kaniharaensis illustrates the interplay between biological pyrazolopyrimidine formation and de novo purine biosynthesis 2019 10.1021/jacs.9b00241 30942582 http://vivo.scripps.edu/individual/endnote181842
http://vivo.scripps.edu/individual/e2n354391 AcademicArticle Structural, kinetic, and mechanistic analysis of an asymmetric 4-oxalocrotonate tautomerase trimer 2019 10.1021/acs.biochem.9b00303 31074977 http://vivo.scripps.edu/individual/endnote165634
http://vivo.scripps.edu/individual/e2n260536 AcademicArticle Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription 2019 10.1074/jbc.RA119.007697 30971428 http://vivo.scripps.edu/individual/endnote308813
http://vivo.scripps.edu/individual/e2n323807 AcademicArticle Phosphatase activity of small C-terminal domain phosphatase 1 (SCP1) controls the stability of the key neuronal regulator RE1-silencing transcription factor (REST) 2018 10.1074/jbc.RA118.004722 30217818 http://vivo.scripps.edu/individual/endnote308813
http://vivo.scripps.edu/individual/e2n210438 AcademicArticle Chemical tools for studying the impact of cis/trans prolyl isomerization on signaling: a case study on RNA polymerase II phosphatase activity and specificity 2018 10.1016/bs.mie.2018.04.020 30149861 http://vivo.scripps.edu/individual/endnote139079
http://vivo.scripps.edu/individual/e2n158332 AcademicArticle Structural characterization of the hydratase-aldolases, NahE and PhdJ: implications for the specificity, catalysis, and N-acetylneuraminate lyase subgroup of the aldolase superfamily 2018 10.1021/acs.biochem.8b00532 29856600 http://vivo.scripps.edu/individual/endnote165634
http://vivo.scripps.edu/individual/e2n293951 AcademicArticle Inactivation of 4-oxalocrotonate tautomerase by 5-Halo-2-hydroxy-2,4-pentadienoates 2018 10.1021/acs.biochem.7600899 29303557 http://vivo.scripps.edu/individual/endnote165634
http://vivo.scripps.edu/individual/e2n274877 AcademicArticle A global view of structure-function relationships in the tautomerase superfamily 2018 10.1074/jbc.M117.815340 29184004 http://vivo.scripps.edu/individual/endnote308813
http://vivo.scripps.edu/individual/e2n128436 AcademicArticle Snapshots of C-S cleavage in Egt2 reveals substrate specificity and reaction mechanism 2018 10.1016/j.chembiol.2018.02.002 29503207 http://vivo.scripps.edu/individual/e2n73778
http://vivo.scripps.edu/individual/e2n10604 AcademicArticle Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain 2017 10.1038/ncomms15233 28497798 http://vivo.scripps.edu/individual/endnote367622
http://vivo.scripps.edu/individual/e2n85559 AcademicArticle Kinetic and structural characterization of a cis-3-Chloroacrylic acid dehalogenase homologue in Pseudomonas sp UW4: A potential step between subgroups in the tautomerase superfamily 2017 10.1016/j.abb.2017.10.018 29111295 http://vivo.scripps.edu/individual/endnote220293
http://vivo.scripps.edu/individual/e2n347502 AcademicArticle Mapping the phosphorylation pattern of Drosophila melanogaster RNA polymerase II carboxyl-terminal domain using ultraviolet photodissociation mass spectrometry 2017 10.1021/acschembio.6b00729 28103682 http://vivo.scripps.edu/individual/endnote153903
http://vivo.scripps.edu/individual/e2n258943 AcademicArticle Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth 2017 10.1038/nm.4232 https://www.nature.com/articles/nm.4232#supplementary-information 27869804 http://vivo.scripps.edu/individual/endnote267122
http://vivo.scripps.edu/individual/e2n358871 AcademicArticle IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions 2017 10.1038/ni.3770 28604720 http://vivo.scripps.edu/individual/endnote396893
http://vivo.scripps.edu/individual/e2n396351 AcademicArticle Structural snapshots of an engineered cystathionine-γ-lyase reveal the critical role of electrostatic interactions in the active site 2017 10.1021/acs.biochem.6b01172 28106980 http://vivo.scripps.edu/individual/endnote165634
http://vivo.scripps.edu/individual/e2n313237 AcademicArticle Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain 2017 10.1038/ncomms15231 28497792 http://vivo.scripps.edu/individual/endnote367622
http://vivo.scripps.edu/individual/e2n39208 AcademicArticle The bacterial catabolism of polycyclic aromatic hydrocarbons: Characterization of three hydratase-aldolase-catalyzed reactions 2016 https://doi.org/10.1016/j.pisc.2016.03.025 http://vivo.scripps.edu/individual/e2n239461
http://vivo.scripps.edu/individual/e2n185506 AcademicArticle Intramolecular cleavage of the hASRGL1 homodimer occurs in two stages 2016 10.1021/acs.biochem.5b01157 26780688 http://vivo.scripps.edu/individual/endnote165634
http://vivo.scripps.edu/individual/e2n356688 AcademicArticle Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase 2016 10.1126/scisignal.aad4805 26933063 http://vivo.scripps.edu/individual/endnote337317
http://vivo.scripps.edu/individual/e2n36042 AcademicArticle Dephosphorylating eukaryotic RNA polymerase II 2016 10.1016/j.bbapap.2016.01.007 26779935 http://vivo.scripps.edu/individual/e2n142586
http://vivo.scripps.edu/individual/e2n80502 AcademicArticle Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease 2015 10.1016/j.nbd.2014.12.027 25576397 http://vivo.scripps.edu/individual/endnote115958
http://vivo.scripps.edu/individual/e2n38618 AcademicArticle Chemical tools to decipher regulation of phosphatases by proline isomerization on eukaryotic RNA polymerase II 2015 10.1021/acschembio.5b00296 26332362 http://vivo.scripps.edu/individual/endnote153903
http://vivo.scripps.edu/individual/e2n66801 AcademicArticle Depletion of fat-resident T-reg cells prevents age-associated insulin resistance 2015 10.1038/nature16151 26580014 http://vivo.scripps.edu/individual/endnote351395
http://vivo.scripps.edu/individual/e2n200681 AcademicArticle Endoperoxide formation by an α-ketoglutarate-dependent mononuclear non-haem iron enzyme 2015 10.1038/nature15519 26524521 http://vivo.scripps.edu/individual/endnote351395
http://vivo.scripps.edu/individual/e2n79063 AcademicArticle A potent and selective inhibitor for the UBLCP1 proteasome phosphatase 2015 10.1016/j.bmc.2015.03.066 25907364 http://vivo.scripps.edu/individual/endnote193708
http://vivo.scripps.edu/individual/e2n216856 AcademicArticle Cross-talk of phosphorylation and prolyl isomerization of the C-terminal domain of RNA Polymerase II 2014 10.3390/molecules19021481 24473209 http://vivo.scripps.edu/individual/endnote281820
http://vivo.scripps.edu/individual/e2n35321 AcademicArticle Characterization of native protein complexes using ultraviolet photodissociation mass spectrometry 2014 10.1021/ja505217w 25148649 http://vivo.scripps.edu/individual/endnote181842
http://vivo.scripps.edu/individual/e2n242828 AcademicArticle Viewing serine/threonine protein phosphatases through the eyes of drug designers 2013 10.1111/febs.12481 23937612 http://vivo.scripps.edu/individual/endnote203539
http://vivo.scripps.edu/individual/e2n219301 AcademicArticle Complete protein characterization using top-down mass spectrometry and ultraviolet photodissociation 2013 10.1021/ja4029654 23697802 http://vivo.scripps.edu/individual/endnote181842
http://vivo.scripps.edu/individual/e2n172401 AcademicArticle Novel modifications on C-terminal domain of RNA polymerase II can fine-tune the phosphatase activity of Ssu72 2013 10.1021/cb400229c 23844594 http://vivo.scripps.edu/individual/endnote153903
http://vivo.scripps.edu/individual/e2n109956 AcademicArticle Calcium/calmodulin stimulates the autophosphorylation of elongation factor 2 kinase on Thr-348 and Ser-500 to regulate its activity and calcium dependence 2012 10.1021/bi201788e 22329831 http://vivo.scripps.edu/individual/endnote165634
http://vivo.scripps.edu/individual/e2n133549 AcademicArticle Uncoupling intramolecular processing and substrate hydrolysis in the N-terminal nucleophile hydrolase hASRGL1 by circular permutation 2012 10.1021/cb300232n 22891768 http://vivo.scripps.edu/individual/endnote153903
http://vivo.scripps.edu/individual/e2n244416 AcademicArticle Structural and kinetic analysis of prolyl-isomerization/phosphorylation cross-talk in the CTD code 2012 10.1021/cb3000887 22670809 http://vivo.scripps.edu/individual/endnote153903
http://vivo.scripps.edu/individual/e2n211482 AcademicArticle Selective inactivation of a human neuronal silencing phosphatase by a small molecule inhibitor 2011 10.1021/cb100357t 21348431 http://vivo.scripps.edu/individual/endnote153903
http://vivo.scripps.edu/individual/e2n98255 AcademicArticle Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II, in complex with a transition state analogue 2011 10.1042/bj20101471 21204787 http://vivo.scripps.edu/individual/endnote277207
http://vivo.scripps.edu/individual/e2n204607 AcademicArticle Kinetic, crystallographic, and mechanistic characterization of TomN: elucidation of a function for a 4-oxalocrotonate tautomerase homologue in the tomaymycin biosynthetic pathway 2011 10.1021/bi200947w 21809870 http://vivo.scripps.edu/individual/endnote165634
http://vivo.scripps.edu/individual/e2n61691 AcademicArticle A reduced-amide inhibitor of Pin1 binds in a conformation resembling a twisted-amide transition state 2011 10.1021/bi201055c 21980916 http://vivo.scripps.edu/individual/endnote165634
http://vivo.scripps.edu/individual/e2n261922 AcademicArticle Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function 2011 10.1016/j.molcel.2011.03.005 21497122 http://vivo.scripps.edu/individual/endnote331988
http://vivo.scripps.edu/individual/e2n289935 AcademicArticle Structural and functional analysis of the phosphoryl transfer reaction mediated by the human small C-terminal domain phosphatase, Scp1 2010 10.1002/pro.375 20222012 http://vivo.scripps.edu/individual/endnote61860
http://vivo.scripps.edu/individual/e2n41877 AcademicArticle Bio-molecular architects: a scaffold provided by the C-terminal domain of eukaryotic RNA polymerase II 2010 10.3402/nano.v1i0.5502 22110856 http://vivo.scripps.edu/individual/e2n152902
http://vivo.scripps.edu/individual/e2n43615 AcademicArticle Structural basis for high-affinity peptide inhibition of human Pin1 2007 10.1021/cb7000044 17518432 http://vivo.scripps.edu/individual/endnote153903
http://vivo.scripps.edu/individual/endnote6614 AcademicArticle Structure-function-folding relationship in a WW domain 2006 10.1073/pnas.0600511103 16807295 http://vivo.scripps.edu/individual/endnote71945
http://vivo.scripps.edu/individual/endnote240992 AcademicArticle Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1 2006 10.1016/j.molcel.2006.10.027 17157258 http://vivo.scripps.edu/individual/endnote331988
http://vivo.scripps.edu/individual/endnote291060 AcademicArticle Synthesis and biological evaluation of N-{4- 5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoro acetyl)pentyl)benzoyl}-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway 2005 10.1016/j.bme.2004.11.049 15848772 http://vivo.scripps.edu/individual/endnote193708
http://vivo.scripps.edu/individual/endnote289349 AcademicArticle Synthesis and biological evaluation of α- and γ-carboxamide derivatives of 10-CF3CO-DDACTHF 2005 10.1016/j.bme.2004.11.050 15848771 http://vivo.scripps.edu/individual/endnote193708
http://vivo.scripps.edu/individual/endnote287545 AcademicArticle Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway 2005 10.1016/j.bmc.2004.12.004 15848770 http://vivo.scripps.edu/individual/endnote193708
http://vivo.scripps.edu/individual/endnote213391 AcademicArticle Crystal structures of apo wild-type M. jannaschii tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O-methyl-L-tyrosine 2005 10.1110/ps.041239305 15840835 http://vivo.scripps.edu/individual/endnote61860
http://vivo.scripps.edu/individual/e2n159186 AcademicArticle Bifunctional abletadiene synthase: mutual structural dependence of the active sites for protonation-initiated and ionization-initiated cyclizations 2003 10.1021/bi020492n 12614165 http://vivo.scripps.edu/individual/endnote165634
http://vivo.scripps.edu/individual/endnote147585 AcademicArticle Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway 2003 10.1016/s0968-0896(03)00458-9 13129587 http://vivo.scripps.edu/individual/endnote193708
http://vivo.scripps.edu/individual/endnote359072 AcademicArticle Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid 2003 10.1021/bi034219c 12755606 http://vivo.scripps.edu/individual/endnote165634
http://vivo.scripps.edu/individual/endnote172922 AcademicArticle Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase 2003 10.1016/s0968-0896(03)00456-5 13129585 http://vivo.scripps.edu/individual/endnote193708
http://vivo.scripps.edu/individual/endnote62339 AcademicArticle 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase 2003 10.1016/s0968-0896(03)00457-7 13129586 http://vivo.scripps.edu/individual/endnote193708
http://vivo.scripps.edu/individual/endnote384272 AcademicArticle Crystal structures of human GAR Tfase at low and high pH and with substrate β-GAR 2002 10.1021/bi020522m 12450384 http://vivo.scripps.edu/individual/endnote165634
http://vivo.scripps.edu/individual/endnote34329 AcademicArticle 10-formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway 2002 10.1016/s0968-0896(02)00102-5 12057663 http://vivo.scripps.edu/individual/endnote193708
http://vivo.scripps.edu/individual/e2n222313 AcademicArticle Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues 1999 10.1021/bi991711g 10555963 http://vivo.scripps.edu/individual/endnote165634

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