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Publication list

publication_uri type publication_title year doi pmid journal_uri
http://vivo.scripps.edu/individual/e2n339448 AcademicArticle Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues 2020 10.1007/s11357-020-00185-1 32285290 http://vivo.scripps.edu/individual/e2n310094
http://vivo.scripps.edu/individual/e2n340930 AcademicArticle Attenuation of ataxia telangiectasia mutated signalling mitigates age-associated intervertebral disc degeneration 2020 10.1111/acel.13162 32567210 http://vivo.scripps.edu/individual/endnote323433
http://vivo.scripps.edu/individual/e2n218943 AcademicArticle ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging 2020 10.18632/aging.102863 32201398 http://vivo.scripps.edu/individual/e2n71102
http://vivo.scripps.edu/individual/e2n165170 AcademicArticle Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice 2020 10.1111/acel.13094 31981461 http://vivo.scripps.edu/individual/endnote323433
http://vivo.scripps.edu/individual/e2n141802 AcademicArticle Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis-like symptoms in NOD mice 2019 10.1096/fj.201900420R 31170010 http://vivo.scripps.edu/individual/endnote8827
http://vivo.scripps.edu/individual/e2n391653 AcademicArticle Measuring biological age in mice using differential mass spectrometry 2019 10.18632/aging.101810 30745468 http://vivo.scripps.edu/individual/e2n43120
http://vivo.scripps.edu/individual/e2n8931 AcademicArticle SA-β-galactosidase-based screening assay for the identification of senotherapeutic drugs 2019 10.3791/58133 31305507 http://vivo.scripps.edu/individual/e6n377271
http://vivo.scripps.edu/individual/e2n349647 AcademicArticle ERCC4 variants identified in a cohort of patients with segmental progeroid syndromes 2018 10.1002/humu.23367 29105242 http://vivo.scripps.edu/individual/endnote174323
http://vivo.scripps.edu/individual/e2n29968 AcademicArticle ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation 2018 10.1016/j.freeradbiomed.2018.05.088 29860127 http://vivo.scripps.edu/individual/endnote226218
http://vivo.scripps.edu/individual/e2n283207 AcademicArticle Senotherapeutics for healthy ageing 2018 29651106 http://vivo.scripps.edu/individual/endnote4577
http://vivo.scripps.edu/individual/e2n179528 AcademicArticle Hsp90 inhibitors as senolytic drugs to extend healthy aging 2018 10.1080/15384101.2018.1475828 29886783 http://vivo.scripps.edu/individual/endnote1780
http://vivo.scripps.edu/individual/e2n215660 AcademicArticle Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation 2018 10.1371/journal.pbio.2004663 29889904 http://vivo.scripps.edu/individual/endnote301474
http://vivo.scripps.edu/individual/e2n316835 AcademicArticle Fisetin is a senotherapeutic that extends health and lifespan 2018 10.1016/j.ebiom.2018.09.015 30279143 http://vivo.scripps.edu/individual/e2n342349
http://vivo.scripps.edu/individual/e2n163111 AcademicArticle Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging 2018 10.1016/j.redox.2018.04.007 29747066 http://vivo.scripps.edu/individual/e2n172831
http://vivo.scripps.edu/individual/e2n68928 AcademicArticle Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging 2018 10.1016/j.redox.2018.06.005 30031267 http://vivo.scripps.edu/individual/e2n172831
http://vivo.scripps.edu/individual/e2n353822 AcademicArticle Senolytics improve physical function and increase lifespan in old age 2018 10.1038/s41591-018-0092-9 29988130 http://vivo.scripps.edu/individual/endnote267122
http://vivo.scripps.edu/individual/e2n3028 AcademicArticle Nuclear genomic instability and aging 2018 10.1146/annurev-biochem-062917-012239 29925262 http://vivo.scripps.edu/individual/endnote150781
http://vivo.scripps.edu/individual/e2n267591 AcademicArticle Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans 2018 10.1111/acel.12706 29290100 http://vivo.scripps.edu/individual/endnote323433
http://vivo.scripps.edu/individual/e2n218294 AcademicArticle Oxidation products of 5-methylcytosine are decreased in senescent cells and tissues of progeroid mice 2018 10.1093/gerona/gly012 29415265 http://vivo.scripps.edu/individual/e2n327080
http://vivo.scripps.edu/individual/e2n330082 AcademicArticle New agents that target senescent cells: the flavone, fisetin, and the BCL-X-L inhibitors, A1331852 and A1155463 2017 10.18632/aging.101202 28273655 http://vivo.scripps.edu/individual/endnote78570
http://vivo.scripps.edu/individual/e2n24062 AcademicArticle Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype 2017 10.1016/j.mad.2017.08.007 28830687 http://vivo.scripps.edu/individual/endnote356793
http://vivo.scripps.edu/individual/e2n200106 AcademicArticle mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging 2017 10.1002/jor.23409 27572850 http://vivo.scripps.edu/individual/endnote177391
http://vivo.scripps.edu/individual/e2n87512 AcademicArticle Systems biology guided by XCMS Online metabolomics 2017 28448069 http://vivo.scripps.edu/individual/endnote37557
http://vivo.scripps.edu/individual/e2n99529 AcademicArticle The clinical potential of senolytic drugs 2017 10.1111/jgs.14969 28869295 http://vivo.scripps.edu/individual/endnote243551
http://vivo.scripps.edu/individual/e2n85966 AcademicArticle Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism 2017 10.1111/acel.12571 28229533 http://vivo.scripps.edu/individual/endnote323433
http://vivo.scripps.edu/individual/e2n102184 AcademicArticle ADAMTS5 deficiency protects mice from chronic tobacco smoking-induced intervertebral disc degeneration 2017 10.1097/brs.0000000000002258 28570296 http://vivo.scripps.edu/individual/endnote96016
http://vivo.scripps.edu/individual/e2n42073 AcademicArticle Advances in therapeutic approaches to extend healthspan: a perspective from the 2nd Scripps Symposium on the Biology of Aging 2017 10.1111/acel.12620 28585366 http://vivo.scripps.edu/individual/endnote323433
http://vivo.scripps.edu/individual/e2n51490 AcademicArticle Molecular pathology endpoints useful for aging studies 2017 10.1016/j.arr.2016.09.012 27721062 http://vivo.scripps.edu/individual/endnote234622
http://vivo.scripps.edu/individual/e2n331530 AcademicArticle Identification of HSP90 inhibitors as a novel class of senolytics 2017 10.1038/s41467-017-00314-z 28871086 http://vivo.scripps.edu/individual/endnote367622
http://vivo.scripps.edu/individual/e2n170549 AcademicArticle Barriers to the preclinical development of therapeutics that target aging mechanisms 2016 10.1093/gerona/glw112 27535964 http://vivo.scripps.edu/individual/endnote262949
http://vivo.scripps.edu/individual/e2n388045 AcademicArticle Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors 2016 10.1111/acel.12445 26711051 http://vivo.scripps.edu/individual/endnote323433
http://vivo.scripps.edu/individual/e2n107048 AcademicArticle Occurrence, biological consequences, and human health relevance of oxidative stress-induced DNA damage 2016 10.1021/acs.chemrestox.6b00265 27989142 http://vivo.scripps.edu/individual/endnote301451
http://vivo.scripps.edu/individual/e2n285959 AcademicArticle Smartphone analytics: mobilizing the lab into the cloud for omicscale analyses 2016 10.1021/acs.analchem.6b02676 27560777 http://vivo.scripps.edu/individual/endnote220455
http://vivo.scripps.edu/individual/e2n294561 AcademicArticle The Geropathology Research Network: An interdisciplinary approach for integrating pathology into research on aging 2016 10.1093/gerona/glv079 26243216 http://vivo.scripps.edu/individual/endnote262949
http://vivo.scripps.edu/individual/e2n211305 AcademicArticle In vivo detection and replication studies of α-anomeric lesions of 2'-deoxyribonucleosides 2015 10.1093/nar/gkv725 26202973 http://vivo.scripps.edu/individual/endnote328162
http://vivo.scripps.edu/individual/e2n302131 AcademicArticle Comparison of mice with accelerated aging caused by distinct mechanisms 2015 10.1016/j.exger.2015.01.045 25617508 http://vivo.scripps.edu/individual/endnote56038
http://vivo.scripps.edu/individual/e2n300703 AcademicArticle Simultaneous quantification of methylated cytidine and adenosine in cellular and tissue RNA by Nano-Flow liquid chromatography-tandem mass spectrometry coupled with the stable isotope-dilution method 2015 10.1021/acs.analchem.5b00951 26158405 http://vivo.scripps.edu/individual/endnote220455
http://vivo.scripps.edu/individual/e2n300958 AcademicArticle The Achilles' heel of senescent cells: from transcriptome to senolytic drugs 2015 10.1111/acel.12344 25754370 http://vivo.scripps.edu/individual/endnote323433
http://vivo.scripps.edu/individual/e11n200536 AcademicArticle Investigating the role of DNA damage in tobacco smoking-induced spine degeneration 2014 10.1016/j.spinee.2013.08.034 24211096 http://vivo.scripps.edu/individual/enote250501
http://vivo.scripps.edu/individual/e14n297045 AcademicArticle Tet-mediated formation of 5-hydroxymethylcytosine in RNA 2014 10.1021/ja505305z 25073028 http://vivo.scripps.edu/individual/endnote181842
http://vivo.scripps.edu/individual/e8n345446 AcademicArticle Pharmacologic IKK/NF-kappa B inhibition causes antigen presenting cells to undergo TNF alpha dependent ROS-mediated programmed cell death 2014 10.1038/srep03631 24406986 http://vivo.scripps.edu/individual/endnote390173
http://vivo.scripps.edu/individual/e1n260629 AcademicArticle An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints 2013 10.1002/jor.22204 23483579 http://vivo.scripps.edu/individual/endnote177391
http://vivo.scripps.edu/individual/e6n183988 AcademicArticle DNA damage triggers a chronic autoinflammatory response, leading to fat depletion in NER progeria 2013 10.1016/j.cmet.2013.08.011 24011075 http://vivo.scripps.edu/individual/endnote333641
http://vivo.scripps.edu/individual/e7n156198 AcademicArticle Advances in understanding the complex mechanisms of DNA interstrand cross-link repair 2013 10.1101/cshperspect.a012732 24086043 http://vivo.scripps.edu/individual/endnote160023
http://vivo.scripps.edu/individual/e7n156198 AcademicArticle Advances in understanding the complex mechanisms of DNA interstrand cross-link repair 2013 10.1101/cshperspect.a012732 24224206 http://vivo.scripps.edu/individual/endnote160023
http://vivo.scripps.edu/individual/enote134468 AcademicArticle Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model 2012 10.1038/ncomms1611 22215083 http://vivo.scripps.edu/individual/endnote367622
http://vivo.scripps.edu/individual/enote247846 AcademicArticle Endogenous formation and repair of oxidatively induced g (8-5m) T intrastrand cross-link lesion 2012 10.1093/nar/gks357 22581771 http://vivo.scripps.edu/individual/endnote328162
http://vivo.scripps.edu/individual/enote161031 AcademicArticle Issls prize winner: Inhibition of nf-kappa b activity ameliorates age-associated disc degeneration in a mouse model of accelerated aging 2012 10.1097/BRS.0b013e31824ee8f7 22343279 http://vivo.scripps.edu/individual/endnote96016
http://vivo.scripps.edu/individual/enote60657 AcademicArticle Downregulation of cholesterol biosynthesis genes in the forebrain of ERCC1-deficient mice 2012 10.1016/j.nbd.2011.12.036 22245387 http://vivo.scripps.edu/individual/endnote115958
http://vivo.scripps.edu/individual/enote224743 AcademicArticle Deficiency of DNA repair nuclease ERCC1-XPF promotes prostate cancer progression in a tissue recombination model 2012 10.1002/pros.22472 22212909 http://vivo.scripps.edu/individual/endnote169436
http://vivo.scripps.edu/individual/enote399129 AcademicArticle Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair 2012 10.1074/jbc.M111.337899 22547097 http://vivo.scripps.edu/individual/endnote308813
http://vivo.scripps.edu/individual/enote197125 AcademicArticle A quantitative assay for assessing the effects of DNA lesions on transcription 2012 10.1038/nchembio.1046 22902614 http://vivo.scripps.edu/individual/endnote16708
http://vivo.scripps.edu/individual/enote246917 AcademicArticle A mouse model of accelerated liver aging caused by a defect in DNA repair 2012 10.1002/hep.24713 21953681 http://vivo.scripps.edu/individual/endnote228478
http://vivo.scripps.edu/individual/enote249618 AcademicArticle Comparison of ERCC1/XPF genetic variation, mRNA and protein levels in women with advanced stage ovarian cancer treated with intraperitoneal platinum 2012 10.1016/j.ygyno.2012.05.006 22609620 http://vivo.scripps.edu/individual/enote378515
http://vivo.scripps.edu/individual/enote353123 AcademicArticle NF-kB inhibition delays DNA damage-induced senescence and aging in mice 2012 10.1172/jci45785 22706308 http://vivo.scripps.edu/individual/endnote119306
http://vivo.scripps.edu/individual/enote242574 AcademicArticle Pre-treatment tumor expression of ERCC1 in women with advanced stage epithelial ovarian cancer is not predictive of clinical outcomes: A gynecologic oncology group study 2012 10.1016/j.ygyno.2012.01.008 22261301 http://vivo.scripps.edu/individual/enote378515
http://vivo.scripps.edu/individual/enote23056 AcademicArticle NF-kB negatively impacts the myogenic potential of muscle-derived stem cells 2012 10.1038/mt.2011.261 22158056 http://vivo.scripps.edu/individual/endnote392215
http://vivo.scripps.edu/individual/enote189102 AcademicArticle Spine degeneration in a murine model of chronic human tobacco smokers 2012 10.1016/j.joca.2012.04.010 22531458 http://vivo.scripps.edu/individual/endnote332000
http://vivo.scripps.edu/individual/enote286364 AcademicArticle The oxidative DNA lesions 8,5'-cyclopurines accumulate with aging in a tissue-specific manner 2012 10.1111/j.1474-9726.2012.00828.x 22530741 http://vivo.scripps.edu/individual/endnote323433
http://vivo.scripps.edu/individual/enote389550 AcademicArticle Bupivacaine decreases cell viability and matrix protein synthesis in an intervertebral disc organ model system 2011 10.1016/j.spinee.2010.11.017 21296298 http://vivo.scripps.edu/individual/enote250501
http://vivo.scripps.edu/individual/enote283670 AcademicArticle Physiological consequences of defects in ercc1-xpf DNA repair endonuclease 2011 10.1016/j.dnarep.2011.04.026 21612988 http://vivo.scripps.edu/individual/endnote152871
http://vivo.scripps.edu/individual/enote83072 AcademicArticle XPF expression correlates with clinical outcome in squamous cell carcinoma of the head and neck 2011 10.1158/1078-0432.ccr-11-0086 21737503 http://vivo.scripps.edu/individual/endnote99243
http://vivo.scripps.edu/individual/enote132092 AcademicArticle Premature aging-related peripheral neuropathy in a mouse model of progeria 2011 10.1016/j.mad,2011.04.010 21596054 http://vivo.scripps.edu/individual/endnote356793
http://vivo.scripps.edu/individual/enote127503 AcademicArticle The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways 2010 10.1074/jbc.M109.067538 19940136 http://vivo.scripps.edu/individual/endnote308813
http://vivo.scripps.edu/individual/enote196169 AcademicArticle Hyper telomere recombination accelerates replicative senescence and may promote premature aging 2010 10.1073/pnas.1006338107 20798040 http://vivo.scripps.edu/individual/endnote71945
http://vivo.scripps.edu/individual/enote144659 AcademicArticle Accelerated aging of intervertebral discs in a mouse model of progeria 2010 10.1002/jor.21153 20973062 http://vivo.scripps.edu/individual/endnote177391
http://vivo.scripps.edu/individual/enote206574 AcademicArticle Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients 2010 10.1371/journal.pgen.1000871 20221251 http://vivo.scripps.edu/individual/endnote193297
http://vivo.scripps.edu/individual/enote275885 AcademicArticle Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue 2009 10.1158/0008-5472.can-09-1237 19723666 http://vivo.scripps.edu/individual/endnote44772
http://vivo.scripps.edu/individual/enote212841 AcademicArticle Mouse models of fanconi anemia 2009 10.1016/j.mrfmmm.2009.03.015 19427003 http://vivo.scripps.edu/individual/endnote92222
http://vivo.scripps.edu/individual/enote359004 AcademicArticle XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair 2009 10.1128/mcb.00086-09 19805513 http://vivo.scripps.edu/individual/endnote52493
http://vivo.scripps.edu/individual/enote324381 AcademicArticle Delayed and accelerated aging share common longevity assurance mechanisms 2008 10.1371/journal.pgen.1000161 18704162 http://vivo.scripps.edu/individual/endnote193297
http://vivo.scripps.edu/individual/enote4050 AcademicArticle Nucleotide excision repair deficient mouse models and neurological disease 2008 10.1016/j.dnarep.2007.12.006 18272436 http://vivo.scripps.edu/individual/endnote152871
http://vivo.scripps.edu/individual/enote316772 AcademicArticle DNA repair is crucial for maintaining hematopoietic stem cell function 2008 10.1016/j.dnarep.2007.11.012 18248857 http://vivo.scripps.edu/individual/endnote152871
http://vivo.scripps.edu/individual/enote154044 AcademicArticle Tissue-specific accelerated aging in nucleotide excision repair deficiency 2008 10.1016/j.mad.2008.04.010 18538374 http://vivo.scripps.edu/individual/endnote356793
http://vivo.scripps.edu/individual/enote344101 AcademicArticle ERCC1-XPF endonuclease facilitates DNA double-strand break repair 2008 10.1128/mcb.00293-08 18541667 http://vivo.scripps.edu/individual/endnote52493
http://vivo.scripps.edu/individual/enote14353 AcademicArticle First reported patient with human ercc1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure 2007 10.1086/512486 17273966 http://vivo.scripps.edu/individual/endnote313029
http://vivo.scripps.edu/individual/enote49785 AcademicArticle Impaired genome maintenance suppresses the growth hormone-insulin-like growth factor 1 axis in mice with cockayne syndrome 2007 10.1371/journal.pbio.0050002 17326724 http://vivo.scripps.edu/individual/endnote301474
http://vivo.scripps.edu/individual/enote375855 AcademicArticle Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice 2006 10.1016/j.mrfmmm.2005.11.008 16472827 http://vivo.scripps.edu/individual/endnote92222
http://vivo.scripps.edu/individual/enote339873 AcademicArticle A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis 2006 10.1038/nature05456 17183314 http://vivo.scripps.edu/individual/endnote351395
http://vivo.scripps.edu/individual/enote82714 AcademicArticle Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient ercc1(-/-) mice 2005 10.1038/sj.emboj.7600542 15692571 http://vivo.scripps.edu/individual/endnote321241
http://vivo.scripps.edu/individual/enote338254 AcademicArticle Fanconi anemia (cross)linked to DNA repair 2005 10.1016/j.cell.2005.12.009 16377561 http://vivo.scripps.edu/individual/endnote126238
http://vivo.scripps.edu/individual/enote72836 AcademicArticle The structure-specific endonuclease ercc1-xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks 2004 10.1128/mcb.24.13.5776-5787.2004 15199134 http://vivo.scripps.edu/individual/endnote52493
http://vivo.scripps.edu/individual/enote211430 AcademicArticle Deletion of the nucleotide excision repair gene ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions 2004 10.1084/jem.20040052 15280420 http://vivo.scripps.edu/individual/endnote111556
http://vivo.scripps.edu/individual/enote45311 AcademicArticle Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells 2003 10.1074/jbc.M212549200 12775726 http://vivo.scripps.edu/individual/endnote308813
http://vivo.scripps.edu/individual/enote324277 AcademicArticle Ercc1/xpf removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes 2003 10.1016/s1097-2765(03)00478-7 14690602 http://vivo.scripps.edu/individual/endnote331988
http://vivo.scripps.edu/individual/enote250913 AcademicArticle Divide and conquer: Nucleotide excision repair battles cancer and ageing 2003 10.1016/s0955-0674(03)00018-8 12648680 http://vivo.scripps.edu/individual/endnote336183
http://vivo.scripps.edu/individual/enote295839 AcademicArticle The structure-specific endonuclease ercc1-xpf is required for targeted gene replacement in embryonic stem cells 2001 10.1093/emboj/20.22.6540 11707424 http://vivo.scripps.edu/individual/endnote321241
http://vivo.scripps.edu/individual/enote268697 AcademicArticle Temperature-dependent formation of a conjugate between tris(hydroxymethyl)aminomethane buffer and the malondialdehyde-DNA adduct pyrimidopurinone 1997 10.1021/tx960191c 9168253 http://vivo.scripps.edu/individual/endnote301451
http://vivo.scripps.edu/individual/enote300987 AcademicArticle Mutagenic and genotoxic effects of three vinyl chloride-induced DNA lesions: 1,N6-ethenoadenine, 3,N4-ethenocytosine, and 4-amino-5-(imidazol-2-yl)imidazole 1993 10.1021/bi00210a031 8251500 http://vivo.scripps.edu/individual/endnote165634
http://vivo.scripps.edu/individual/enote64672 AcademicArticle Deoxyhexanucleotide containing a vinyl-chloride induced dna lesion, 1,n6-ethenoadenine - synthesis, physical characterization, and incorporation into a duplex bacteriophage-m13 genome as part of an amber codon 1987 10.1021/bi00392a007 3314993 http://vivo.scripps.edu/individual/endnote165634

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