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Serine Proteases

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  • A brain detoxifying enzyme for organophosphorus nerve poisons  Academic Article
  • A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity  Academic Article
  • A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis  Academic Article
  • Application of activity-based protein profiling to study enzyme function in adipocytes  Academic Article
  • Cholesteryl ester hydrolase activity is abolished in HSL(-/-) macrophages but unchanged in macrophages lacking KIAA1363  Academic Article
  • Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors  Academic Article
  • Discovery libraries targeting the major enzyme classes: the serine hydrolases  Academic Article
  • Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification  Academic Article
  • In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated beta1 integrin and induction of FAK/PI3K/Akt motility signaling  Academic Article
  • Proteolysis-induced n-terminal ectodomain shedding of the integral membrane glycoprotein cub domain-containing protein 1 (cdcp1) is accompanied by tyrosine phosphorylation of its c-terminal domain and recruitment of src and pkc delta  Academic Article
  • Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition  Academic Article
  • Selective inhibition of plant serine hydrolases by agrochemicals revealed by competitive ABPP  Academic Article
  • Serine hydrolase KIAA1363: Toxicological and structural features with emphasis on organophosphate interactions  Academic Article
  • Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis  Academic Article
  • Targeting tumor cell invasion and dissemination in vivo by an aptamer that inhibits urokinase-type plasminogen activator through a novel multifunctional mechanism  Academic Article

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