subject area of
- A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin Academic Article
- A computational framework for proteome-wide pursuit and prediction of metalloproteins using ICP-MS and MS/MS data Academic Article
- A conserved MutS homolog connector domain interface interacts with MutL homologs Academic Article
- A de novo protein binding pair by computational design and directed evolution Academic Article
- A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV Academic Article
- A protein domain-based interactome network for C. elegans early embryogenesis Academic Article
- A role for the essential yycg sensor histidine kinase in sensing cell division Academic Article
- A separable domain of the p150 subunit of human chromatin assembly factor-1 promotes protein and chromosome associations with nucleoli Academic Article
- A sequence-specific transcription activator motif and powerful synthetic variants that bind Mediator using a fuzzy protein interface Academic Article
- A sim-ultaneous role for SUMO and ubiquitin Academic Article
- Acidic residues in the membrane-proximal stalk region of vaccinia virus protein B5 are required for glycosaminoglycan-mediated disruption of the extracellular enveloped virus outer membrane Academic Article
- Adhesion and fusion efficiencies of human immunodeficiency virus type 1 (HIV-1) surface proteins Academic Article
- An essential sensor histidine kinase controlled by transmembrane helix interactions with its auxiliary proteins Academic Article
- Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env Academic Article
- Autodeimination of protein arginine deiminase 4 alters protein-protein interactions but not activity Academic Article
- Automated docking with protein flexibility in the design of femtomolar "click chemistry" inhibitors of acetylcholinesterase Academic Article
- Backbone engineering within a latent β-hairpin structure to design inhibitors of polyglutamine amyloid formation Academic Article
- CRTC1/MAML2 gain-of-function interactions with MYC create a gene signature predictive of cancers with CREB-MYC involvement Academic Article
- Changes in active site histidine hydrogen bonding trigger cryptochrome activation Academic Article
- Characterization of TAZ domains important for the induction of breast cancer stem cell properties and tumorigenesis Academic Article
- Chemical synthesis and biotinylation of the thrombospondin domain TSR2 Academic Article
- Co-folding of a FliF-FliG split domain forms the basis of the MS:C ring interface within the bacterial flagellar motor Academic Article
- Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold Academic Article
- Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope Academic Article
- Computational design of proteins targeting the conserved stem region of influenza hemagglutinin Academic Article
- Conformational changes associated with the binding of zinc acetate at the putative active site of XcTcmJ, a cupin from Xanthomonas Campestris pv. Campestris Academic Article
- Correlating structure and function of drug-metabolizing enzymes: progress and ongoing challenges Academic Article
- Crosslinking studies of protein-protein interactions in nonribosomal peptide biosynthesis Academic Article
- Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5 Academic Article
- Crystal structure of human adenovirus at 3.5 Å resolution Academic Article
- Crystal structure of the C-terminal domain of mouse TLR9 Academic Article
- Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine Academic Article
- DARC 2.0: Improved docking and virtual screening at protein interaction sites Academic Article
- DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex Academic Article
- DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes Academic Article
- Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function Academic Article
- Dispersed disease-causing neomorphic mutations on a single protein promote the same localized conformational opening Academic Article
- Diverse antibody genetic and recognition properties revealed following HIV-1 envelope glycoprotein immunization Academic Article
- Dynamin-catalyzed membrane fission requires coordinated GTP hydrolysis Academic Article
- Early emergence of negative regulation of the tyrosine kinase Src by the C-terminal Src kinase Academic Article
- Engineered mutations change the structure and stability of a virus-like particle Academic Article
- Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection Academic Article
- Evidence-based annotation of the malaria parasite's genome using comparative expression profiling Academic Article
- Family-wide investigation of PDZ domain-mediated protein-protein interactions implicates β-catenin in maintaining the integrity of tight junctions Academic Article
- Fluorotryptophan incorporation modulates the structure and stability of transthyretin in a site-specific manner Academic Article
- FoldGPCR: Structure prediction protocol for the transmembrane domain of G protein-coupled receptors from class A Academic Article
- Functional interaction of heat shock protein 90 and beclin 1 modulates toll-like receptor-mediated autophagy Academic Article
- GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development Academic Article
- HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors Academic Article
- Heme binding to the mammalian circadian clock protein period 2 is nonspecific Academic Article
- Heparin binds 8 kDa gelsolin cross-β-sheet oligomers and accelerates amyloidogenesis by hastening fibril extension Academic Article
- Hotspot-centric de novo design of protein binders Academic Article
- Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses Academic Article
- Hypoxia-inducible factors P-ER/ARNT/S-IM domains: structure and function Academic Article
- Identification and characterization of the linear region of ATG3 that interacts with ATG7 in higher eukaryotes Academic Article
- Identification of Exo1-Msh2 interaction motifs in DNA mismatch repair and new Msh2-binding partners Academic Article
- Identification of cys255 in hif-1 alpha as a novel site for development of covalent inhibitors of hif-1 alpha/arnt pasb domain protein-protein interaction Academic Article
- Identification of microprotein-protein interactions via APEX tagging Academic Article
- In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity Academic Article
- Inhibition of histone binding by supramolecular hosts Academic Article
- Inhibitor of MYC identified in a Krohnke pyridine library Academic Article
- Isotropic bicelles stabilize the juxtamembrane region of the influenza M2 protein for solution NMR studies Academic Article
- Lyso-sulfatide binds factor Xa and inhibits thrombin generation by the prothrombinase complex Academic Article
- Malachite green mediates homodimerization of antibody VL domains to form a fluorescent ternary complex with singular symmetric interfaces Academic Article
- Mapping the interactions of the p53 transactivation domain with the kix domain of cbp Academic Article
- Massively parallel functional analysis of BRCA1 RING domain variants Academic Article
- Minimalist synthetic host with stacked guanidinium ions mimics the weakened hydration shells of protein-protein interaction interfaces Academic Article
- Model building and refinement of a natively glycosylated HIV-1 Env protein by high-resolution cryoelectron microscopy Academic Article
- Molecular architecture of human polycomb repressive complex 2 Academic Article
- Molecular insights into gamma delta T cell costimulation by an anti-JAML antibody Academic Article
- Munc13-4 Is a Rab11-binding protein that regulates Rab11-positive vesicle trafficking and docking at the plasma membrane Academic Article
- Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle Academic Article
- Noncanonical PAR3 activation by factor Xa identifies a novel pathway for Tie2 activation and stabilization of vascular integrity Academic Article
- Organocatalytic, diastereo- and enantioselective synthesis of nonsymmetric cis-stilbene diamines: a platform for the preparation of single-enantiomer cis-imidazolines for protein-protein inhibition Academic Article
- Overlapping and distinct functions of CstF64 and CstF64 tau in mammalian mRNA 3' processing Academic Article
- Oxime side-chain cross-links in an α-helical coiled-coil protein: structure, thermodynamics, and folding-templated synthesis of bicyclic species Academic Article
- PCNA and Msh2-Msh6 activate an Mlh1-Pms1 endonuclease pathway required for Exo1-independent mismatch repair Academic Article
- Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint Academic Article
- Phosphotyrosine signaling proteins that drive oncogenesis tend to be highly interconnected Academic Article
- Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability Academic Article
- Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase using mechanism-based crosslinkers Academic Article
- Probing the substrate specificity and protein-protein interactions of the E. coli fatty acid dehydratase, FabA Academic Article
- Production, characterization, and assessment of a stable analog of the response regulator CheY-phosphate from Thermotoga maritima Academic Article
- Protein conformation ensembles monitored by HDX reveal a structural rationale for abscisic acid signaling protein affinities and activities Academic Article
- Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation Academic Article
- Protein-protein interaction prediction by combined analysis of genomic and conservation information Academic Article
- Quantifying protein-protein interactions in high throughput using protein domain microarrays Academic Article
- Quantitative analysis of multisite protein-ligand interactions by NMR: binding of intrinsically disordered p53 transactivation subdomains with the TAZ2 domain of CBP Academic Article
- Repression of G1/S transcription is mediated via interaction of the GTB motifs of Nrm1 and Whi5 with Swi6 Academic Article
- Residue-Specific Peptide Modification: A Chemist's Guide Academic Article
- Role of disorder in i?B-nf?B interaction Academic Article
- Role of intrinsic protein disorder in the function and interactions of the transcriptional coactivators CREB-binding protein (CBP) and p300 Academic Article
- Selective inhibition of mitochondrial jnk signaling achieved using peptide mimicry of the sab kinase interacting motif-1 (kim1) Academic Article
- Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents Academic Article
- Snx9 activities are regulated by multiple phosphoinositides through both px and bar domains Academic Article
- Specific binding of a beta-cyclodextrin dimer to the amyloid beta peptide modulates the peptide aggregation process Academic Article
- Structural and functional analysis of the globular head domain of p115 provides insight into membrane tethering Academic Article
- Structural disorder in expanding the functionome of aminoacyl-tRNA synthetases Academic Article
- Structural insights into the interaction of IL-33 with its receptors Academic Article
- Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors Academic Article
- Structural switch of lysyl-tRNA synthetase between translation and transcription Academic Article
- Structure and functional characterization of the rna-binding element of the nlrx1 innate immune modulator Academic Article
- Structure of 2G12 Fab2 in complex with soluble and fully glycosylated HIV-1 Env by negative-stain single-particle electron microscopy Academic Article
- Structure of a trimeric nucleoporin complex reveals alternate oligomerization states Academic Article
- Structure-based vaccine design in hiv: Blind men and the elephant? Academic Article
- Synthetic trimethyllysine receptors that bind histone 3, trimethyllysine 27 (H3K27me3) and disrupt its interaction with the epigenetic reader protein CBX7 Academic Article
- Systematic analysis of bacterial effector-postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domain interactions demonstrates Shigella OspE protein promotes protein kinase C activation via PDLIM proteins Academic Article
- Tensin2 is a novel mediator in thrombopoietin (TPO)-induced cellular proliferation by promoting Akt signaling Academic Article
- The C-terminal region of lymphocytic choriomeningitis virus nucleoprotein contains distinct and segregable functional domains involved in NP-Z interaction and counteraction of the type I interferon response Academic Article
- The N-terminal domain of Escherichia coli assimilatory NADPH-Sulfite reductase hemoprotein is an oligomerization domain that mediates holoenzyme assembly Academic Article
- The bard1 c-terminal domain structure and interactions with polyadenylation factor cstf-50 Academic Article
- The ebola virus interferon antagonist vp24 directly binds stat1 and has a novel, pyramidal fold Academic Article
- The metavinculin tail domain directs constitutive interactions with raver1 and vinculin RNA Academic Article
- The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K Academic Article
- Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein lb Academic Article
- Visualizing the chain-flipping mechanism in fatty-acid biosynthesis Academic Article