subject area of

• 50 Years of structural immunology  Academic Article
• A combined EM and proteomic analysis places HIV-1 Vpu at the crossroads of retromer and ESCRT complexes: PTPN23 is a Vpu-cofactor  Academic Article
• A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin  Academic Article
• A computational framework for proteome-wide pursuit and prediction of metalloproteins using ICP-MS and MS/MS data  Academic Article
• A conserved MutS homolog connector domain interface interacts with MutL homologs  Academic Article
• A de novo protein binding pair by computational design and directed evolution  Academic Article
• A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV  Academic Article
• A protein domain-based interactome network for C. elegans early embryogenesis  Academic Article
• A role for the essential yycg sensor histidine kinase in sensing cell division  Academic Article
• A separable domain of the p150 subunit of human chromatin assembly factor-1 promotes protein and chromosome associations with nucleoli  Academic Article
• A sequence-specific transcription activator motif and powerful synthetic variants that bind Mediator using a fuzzy protein interface  Academic Article
• A sim-ultaneous role for SUMO and ubiquitin  Academic Article
• Acidic residues in the membrane-proximal stalk region of vaccinia virus protein B5 are required for glycosaminoglycan-mediated disruption of the extracellular enveloped virus outer membrane  Academic Article
• Adhesion and fusion efficiencies of human immunodeficiency virus type 1 (HIV-1) surface proteins  Academic Article
• An allosteric peptide inhibitor of HIF-1α regulates hypoxia-induced retinal neovascularization  Academic Article
• An essential sensor histidine kinase controlled by transmembrane helix interactions with its auxiliary proteins  Academic Article
• An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7  Academic Article
• Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env  Academic Article
• Autodeimination of protein arginine deiminase 4 alters protein-protein interactions but not activity  Academic Article
• Automated docking with protein flexibility in the design of femtomolar "click chemistry" inhibitors of acetylcholinesterase  Academic Article
• Backbone engineering within a latent β-hairpin structure to design inhibitors of polyglutamine amyloid formation  Academic Article
• CRTC1/MAML2 gain-of-function interactions with MYC create a gene signature predictive of cancers with CREB-MYC involvement  Academic Article
• Changes in active site histidine hydrogen bonding trigger cryptochrome activation  Academic Article
• Characterization of TAZ domains important for the induction of breast cancer stem cell properties and tumorigenesis  Academic Article
• Characterization of the High-Affinity Fuzzy Complex between the Disordered Domain of the E7 Oncoprotein from High-Risk HPV and the TAZ2 Domain of CBP  Academic Article
• Chemical synthesis and biotinylation of the thrombospondin domain TSR2  Academic Article
• Co-folding of a FliF-FliG split domain forms the basis of the MS:C ring interface within the bacterial flagellar motor  Academic Article
• Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold  Academic Article
• Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope  Academic Article
• Computational design of proteins targeting the conserved stem region of influenza hemagglutinin  Academic Article
• Conformational changes associated with the binding of zinc acetate at the putative active site of XcTcmJ, a cupin from Xanthomonas Campestris pv. Campestris  Academic Article
• Correlating structure and function of drug-metabolizing enzymes: progress and ongoing challenges  Academic Article
• Cross-Neutralization of a SARS-CoV-2 Antibody to a Functionally Conserved Site Is Mediated by Avidity  Academic Article
• Crosslinking studies of protein-protein interactions in nonribosomal peptide biosynthesis  Academic Article
• Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5  Academic Article
• Crystal structure of human adenovirus at 3.5 Å resolution  Academic Article
• Crystal structure of the C-terminal domain of mouse TLR9  Academic Article
• Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine  Academic Article
• DARC 2.0: Improved docking and virtual screening at protein interaction sites  Academic Article
• DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex  Academic Article
• DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes  Academic Article
• Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function  Academic Article
• Design of immunogens to elicit broadly neutralizing antibodies against HIV targeting the CD4 binding site  Academic Article
• Dispersed disease-causing neomorphic mutations on a single protein promote the same localized conformational opening  Academic Article
• Diverse antibody genetic and recognition properties revealed following HIV-1 envelope glycoprotein immunization  Academic Article
• Dynamin-catalyzed membrane fission requires coordinated GTP hydrolysis  Academic Article
• Early emergence of negative regulation of the tyrosine kinase Src by the C-terminal Src kinase  Academic Article
• Engineered mutations change the structure and stability of a virus-like particle  Academic Article
• Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection  Academic Article
• Evidence-based annotation of the malaria parasite's genome using comparative expression profiling  Academic Article
• Family-wide investigation of PDZ domain-mediated protein-protein interactions implicates β-catenin in maintaining the integrity of tight junctions  Academic Article
• Fluorotryptophan incorporation modulates the structure and stability of transthyretin in a site-specific manner  Academic Article
• FoldGPCR: Structure prediction protocol for the transmembrane domain of G protein-coupled receptors from class A  Academic Article
• Functional interaction of heat shock protein 90 and beclin 1 modulates toll-like receptor-mediated autophagy  Academic Article
• Functional landscape of SARS-CoV-2 cellular restriction  Academic Article
• GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development  Academic Article
• HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors  Academic Article
• Heme binding to the mammalian circadian clock protein period 2 is nonspecific  Academic Article
• Heparin binds 8 kDa gelsolin cross-β-sheet oligomers and accelerates amyloidogenesis by hastening fibril extension  Academic Article
• Hotspot-centric de novo design of protein binders  Academic Article
• Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses  Academic Article
• Hypoxia-inducible factors P-ER/ARNT/S-IM domains: structure and function  Academic Article
• Identification and characterization of the linear region of ATG3 that interacts with ATG7 in higher eukaryotes  Academic Article
• Identification of Exo1-Msh2 interaction motifs in DNA mismatch repair and new Msh2-binding partners  Academic Article
• Identification of cys255 in hif-1 alpha as a novel site for development of covalent inhibitors of hif-1 alpha/arnt pasb domain protein-protein interaction  Academic Article
• Identification of microprotein-protein interactions via APEX tagging  Academic Article
• In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity  Academic Article
• Inhibition of histone binding by supramolecular hosts  Academic Article
• Inhibitor of MYC identified in a Krohnke pyridine library  Academic Article
• Isotropic bicelles stabilize the juxtamembrane region of the influenza M2 protein for solution NMR studies  Academic Article
• Lyso-sulfatide binds factor Xa and inhibits thrombin generation by the prothrombinase complex  Academic Article
• Malachite green mediates homodimerization of antibody VL domains to form a fluorescent ternary complex with singular symmetric interfaces  Academic Article
• Mapping glycan-mediated galectin-3 interactions by live cell proximity labeling  Academic Article
• Mapping the interactions of the p53 transactivation domain with the kix domain of cbp  Academic Article
• Massively parallel functional analysis of BRCA1 RING domain variants  Academic Article
• Minimalist synthetic host with stacked guanidinium ions mimics the weakened hydration shells of protein-protein interaction interfaces  Academic Article
• Model building and refinement of a natively glycosylated HIV-1 Env protein by high-resolution cryoelectron microscopy  Academic Article
• Molecular architecture of human polycomb repressive complex 2  Academic Article
• Molecular insights into gamma delta T cell costimulation by an anti-JAML antibody  Academic Article
• Munc13-4 Is a Rab11-binding protein that regulates Rab11-positive vesicle trafficking and docking at the plasma membrane  Academic Article
• Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle  Academic Article
• Noncanonical PAR3 activation by factor Xa identifies a novel pathway for Tie2 activation and stabilization of vascular integrity  Academic Article
• Organocatalytic, diastereo- and enantioselective synthesis of nonsymmetric cis-stilbene diamines: a platform for the preparation of single-enantiomer cis-imidazolines for protein-protein inhibition  Academic Article
• Overlapping and distinct functions of CstF64 and CstF64 tau in mammalian mRNA 3' processing  Academic Article
• Oxime side-chain cross-links in an α-helical coiled-coil protein: structure, thermodynamics, and folding-templated synthesis of bicyclic species  Academic Article
• PCNA and Msh2-Msh6 activate an Mlh1-Pms1 endonuclease pathway required for Exo1-independent mismatch repair  Academic Article
• Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint  Academic Article
• Phosphotyrosine signaling proteins that drive oncogenesis tend to be highly interconnected  Academic Article
• Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability  Academic Article
• Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase using mechanism-based crosslinkers  Academic Article
• Probing the substrate specificity and protein-protein interactions of the E. coli fatty acid dehydratase, FabA  Academic Article
• Production, characterization, and assessment of a stable analog of the response regulator CheY-phosphate from Thermotoga maritima  Academic Article
• Programmable base editing of A.T to G.C in genomic DNA without DNA cleavage  Academic Article
• Protein conformation ensembles monitored by HDX reveal a structural rationale for abscisic acid signaling protein affinities and activities  Academic Article
• Protein design-scapes generated by microfluidic DNA assembly elucidate domain coupling in the bacterial histidine kinase CpxA  Academic Article
• Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation  Academic Article
• Protein-protein interaction prediction by combined analysis of genomic and conservation information  Academic Article
• Quantifying protein-protein interactions in high throughput using protein domain microarrays  Academic Article
• Quantitative analysis of multisite protein-ligand interactions by NMR: binding of intrinsically disordered p53 transactivation subdomains with the TAZ2 domain of CBP  Academic Article
• Repression of G1/S transcription is mediated via interaction of the GTB motifs of Nrm1 and Whi5 with Swi6  Academic Article
• Residue-Specific Peptide Modification: A Chemist's Guide  Academic Article
• Role of disorder in i?B-nf?B interaction  Academic Article
• Role of intrinsic protein disorder in the function and interactions of the transcriptional coactivators CREB-binding protein (CBP) and p300  Academic Article
• Selective inhibition of mitochondrial jnk signaling achieved using peptide mimicry of the sab kinase interacting motif-1 (kim1)  Academic Article
• Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents  Academic Article
• Snx9 activities are regulated by multiple phosphoinositides through both px and bar domains  Academic Article
• Specific binding of a beta-cyclodextrin dimer to the amyloid beta peptide modulates the peptide aggregation process  Academic Article
• Structural and functional analysis of the globular head domain of p115 provides insight into membrane tethering  Academic Article
• Structural disorder in expanding the functionome of aminoacyl-tRNA synthetases  Academic Article
• Structural insights into the interaction of IL-33 with its receptors  Academic Article
• Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors  Academic Article
• Structural switch of lysyl-tRNA synthetase between translation and transcription  Academic Article
• Structure and functional characterization of the rna-binding element of the nlrx1 innate immune modulator  Academic Article
• Structure of 2G12 Fab2 in complex with soluble and fully glycosylated HIV-1 Env by negative-stain single-particle electron microscopy  Academic Article
• Structure of a trimeric nucleoporin complex reveals alternate oligomerization states  Academic Article
• Structure, lipid scrambling activity and role in autophagosome formation of ATG9A  Academic Article
• Structure-based vaccine design in hiv: Blind men and the elephant?  Academic Article
• Synthetic trimethyllysine receptors that bind histone 3, trimethyllysine 27 (H3K27me3) and disrupt its interaction with the epigenetic reader protein CBX7  Academic Article
• Systematic analysis of bacterial effector-postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domain interactions demonstrates Shigella OspE protein promotes protein kinase C activation via PDLIM proteins  Academic Article
• Tensin2 is a novel mediator in thrombopoietin (TPO)-induced cellular proliferation by promoting Akt signaling  Academic Article
• The C-terminal region of lymphocytic choriomeningitis virus nucleoprotein contains distinct and segregable functional domains involved in NP-Z interaction and counteraction of the type I interferon response  Academic Article
• The Cryogenic Electron Microscopy Structure of the Cell Adhesion Regulator Metavinculin Reveals an Isoform-Specific Kinked Helix in Its Cytoskeleton Binding Domain  Academic Article
• The Membrane- and Soluble-Protein Helix-Helix Interactome: Similar Geometry via Different Interactions  Academic Article
• The N-terminal domain of Escherichia coli assimilatory NADPH-Sulfite reductase hemoprotein is an oligomerization domain that mediates holoenzyme assembly  Academic Article
• The bard1 c-terminal domain structure and interactions with polyadenylation factor cstf-50  Academic Article
• The ebola virus interferon antagonist vp24 directly binds stat1 and has a novel, pyramidal fold  Academic Article
• The metavinculin tail domain directs constitutive interactions with raver1 and vinculin RNA  Academic Article
• The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K  Academic Article
• Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein lb  Academic Article
• Visualizing the chain-flipping mechanism in fatty-acid biosynthesis  Academic Article