subject area of
- A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic characteristics Academic Article
- A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival Academic Article
- A peptide-major histocompatibility complex II chimera favors survival of pancreatic beta-islets grafted in type 1 diabetic mice Academic Article
- A small molecule that directs differentiation of human ESCs into the pancreatic lineage Academic Article
- AAV8-mediated gene transfer of interleukin-4 to endogenous beta-cells prevents the onset of diabetes in NOD mice Academic Article
- Adenovirus e3 mhc inhibitory genes but not tnf/fas apoptotic inhibitory genes expressed in beta cells prevent autoimmune diabetes Academic Article
- An isogenic human ESC platform for functional evaluation of genome-wide-association-study-identified diabetes genes and drug discovery Academic Article
- Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates streptozotocin-induced apoptosis of pancreatic beta-cells Academic Article
- Cellular mechanisms of restored β-cell tolerance mediated by protective alleles of Idd3 and Idd5 Academic Article
- Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido )nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus Academic Article
- Discovery of a drug candidate for GLIS3-associated diabetes Academic Article
- DsAAV8-mediated expression of glucagon-like peptide-1 in pancreatic beta-cells ameliorates streptozotocin-induced diabetes Academic Article
- DsAAV8-mediated gene transfer and beta-cell expression of IL-4 and beta-cell growth factors are capable of reversing early-onset diabetes in NOD mice Academic Article
- Exploring stem cell biology with small molecules Academic Article
- Human pancreatic beta-like cells converted from fibroblasts Academic Article
- Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice Academic Article
- In vivo expression of HGF/NK1 and GLP-1 from dsAAV vectors enhances pancreatic beta-cell proliferation and improves pathology in the db/db mouse model of diabetes Academic Article
- Insulinoma-released exosomes or microparticles are immunostimulatory and can activate autoreactive T cells spontaneously developed in nonobese diabetic mice Academic Article
- Matched miRNA and mRNA signatures from an hESC-based in vitro model of pancreatic differentiation reveal novel regulatory interactions Academic Article
- Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release Academic Article
- Molecular anatomy and number of antigen specific CD8 T cells required to cause type 1 diabetes Academic Article
- Negative regulators of insulin signaling revealed in a genome-wide functional screen Academic Article
- Pancreas-specific delivery of β-cell proliferating small molecules Academic Article
- Pancreatic beta-cell neogenesis by direct conversion from mature alpha-cells Academic Article
- Pluripotent stem cell-derived pancreatic β-cells: potential for regenerative medicine in diabetes Academic Article
- ROCKII inhibition promotes the maturation of human pancreatic beta-like cells Academic Article
- Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages Academic Article
- Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-jun N-terminal kinase 3 (JNK3) over p38 Academic Article
- Suppressors of superoxide production from mitochondrial complex III Academic Article
- Systematically labeling developmental stage-specific genes for the study of pancreatic β-cell differentiation from human embryonic stem cells Academic Article
- The IRE1 α/XBP1s pathway is essential for the glucose response and protection of β cells Academic Article
- The apoptotic pathway contributing to the deletion of naive CD8 T cells during the induction of peripheral tolerance to a cross-presented self-antigen Academic Article
- Using hESCs to probe the interaction of the diabetes-associated genes CDKAL1 and MT1E Academic Article