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Insulin-Secreting Cells

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  • A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic characteristics  Academic Article
  • A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival  Academic Article
  • A peptide-major histocompatibility complex II chimera favors survival of pancreatic beta-islets grafted in type 1 diabetic mice  Academic Article
  • A small molecule that directs differentiation of human ESCs into the pancreatic lineage  Academic Article
  • A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype  Academic Article
  • AAV8-mediated gene transfer of interleukin-4 to endogenous beta-cells prevents the onset of diabetes in NOD mice  Academic Article
  • Adenovirus e3 mhc inhibitory genes but not tnf/fas apoptotic inhibitory genes expressed in beta cells prevent autoimmune diabetes  Academic Article
  • An isogenic human ESC platform for functional evaluation of genome-wide-association-study-identified diabetes genes and drug discovery  Academic Article
  • Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates streptozotocin-induced apoptosis of pancreatic beta-cells  Academic Article
  • Cellular mechanisms of restored β-cell tolerance mediated by protective alleles of Idd3 and Idd5  Academic Article
  • Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido )nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus  Academic Article
  • Discovery of a drug candidate for GLIS3-associated diabetes  Academic Article
  • DsAAV8-mediated expression of glucagon-like peptide-1 in pancreatic beta-cells ameliorates streptozotocin-induced diabetes  Academic Article
  • DsAAV8-mediated gene transfer and beta-cell expression of IL-4 and beta-cell growth factors are capable of reversing early-onset diabetes in NOD mice  Academic Article
  • Exploring stem cell biology with small molecules  Academic Article
  • Human pancreatic beta-like cells converted from fibroblasts  Academic Article
  • Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice  Academic Article
  • In vivo expression of HGF/NK1 and GLP-1 from dsAAV vectors enhances pancreatic beta-cell proliferation and improves pathology in the db/db mouse model of diabetes  Academic Article
  • Increased insulin sensitivity and diminished pancreatic beta-cell function in DNA repair deficient Ercc1(d/-) mice  Academic Article
  • Insulinoma-released exosomes or microparticles are immunostimulatory and can activate autoreactive T cells spontaneously developed in nonobese diabetic mice  Academic Article
  • Matched miRNA and mRNA signatures from an hESC-based in vitro model of pancreatic differentiation reveal novel regulatory interactions  Academic Article
  • Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release  Academic Article
  • Molecular anatomy and number of antigen specific CD8 T cells required to cause type 1 diabetes  Academic Article
  • Negative regulators of insulin signaling revealed in a genome-wide functional screen  Academic Article
  • Pancreas-specific delivery of β-cell proliferating small molecules  Academic Article
  • Pancreatic beta-cell neogenesis by direct conversion from mature alpha-cells  Academic Article
  • Pluripotent stem cell-derived pancreatic β-cells: potential for regenerative medicine in diabetes  Academic Article
  • ROCKII inhibition promotes the maturation of human pancreatic beta-like cells  Academic Article
  • Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages  Academic Article
  • Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-jun N-terminal kinase 3 (JNK3) over p38  Academic Article
  • Suppressors of superoxide production from mitochondrial complex III  Academic Article
  • Systematically labeling developmental stage-specific genes for the study of pancreatic β-cell differentiation from human embryonic stem cells  Academic Article
  • The IRE1 α/XBP1s pathway is essential for the glucose response and protection of β cells  Academic Article
  • The apoptotic pathway contributing to the deletion of naive CD8 T cells during the induction of peripheral tolerance to a cross-presented self-antigen  Academic Article
  • Using hESCs to probe the interaction of the diabetes-associated genes CDKAL1 and MT1E  Academic Article
  • β Cell GHS-R Regulates Insulin Secretion and Sensitivity  Academic Article

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