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Antineoplastic Agents, Alkylating

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  • A combination of low-dose cyclophosphamide and colony-stimulating factors is more cost-effective than granulocyte-colony-stimulating factors alone in mobilizing peripheral blood stem and progenitor cells  Academic Article
  • A fundamental relationship between hydrophobic properties and biological activity for the duocarmycin class of DNA-alkylating antitumor drugs: hydrophobic-binding-driven bonding  Academic Article
  • Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin  Academic Article
  • Arresting cancer proliferation by small-molecule gene regulation  Academic Article
  • Bifunctional alkylating agents derived from duocarmycin SA: Potent antitumor activity with altered sequence selectivity  Academic Article
  • CBI-CDPBO1 and CBI-CDPBI1 - CC-1065 analogs containing deep-seated modifications in the DNA-binding subunit  Academic Article
  • Characterization of a side population of astrocytoma cells in response to temozolomide  Academic Article
  • Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells  Academic Article
  • Design, synthesis, and evaluation of duocarmycin O-amino phenol prodrugs subject to tunable reductive activation  Academic Article
  • Discrete roles of the Spc1 kinase and the Atf1 transcription factor in the UV response of Schizosaccharomyces pombe  Academic Article
  • Growth arrest of BCR-ABL positive cells with a sequence-specific polyamide-chlorambucil conjugate  Academic Article
  • High resolution solution structure of a DNA duplex alkylated by the antitumor agent duocarmycin SA  Academic Article
  • Mass spectrometry-based quantification of the cellular response to methyl methanesulfonate treatment in human cells  Academic Article
  • Mechanisms of in situ activation for DNA-targeting antitumor agents  Academic Article
  • Modulation of the maladaptive stress response to manage diseases of protein folding  Academic Article
  • Molecular evolution of Theta-class glutathione transferase for enhanced activity with the anticancer drug 1,3-bis-(2-chloroethyl)-1-nitrosourea and other alkylating agents  Academic Article
  • NMR structure of the (+)-CPI-indole/d(GACTAATTGAC)-d(GTCAATTAGTC) covalent complex  Academic Article
  • Potent activity against K562 cells by polyamide-seco-CBI conjugates targeting histone H4 genes  Academic Article
  • Resolution of a CPzl precursor, synthesis and biological evaluation of (+) and (-)-NBoc-CPzl: a further validation of the relationship between chemical solvolytic stability and cytotoxicity  Academic Article
  • Role of O-6-methylguanine-DNA methyltransferase, glutathione transferase M3-3 and glutathione in resistance to carmustine in a human non-small cell lung cancer cell line  Academic Article
  • Structure-activity studies of antitumor agent irofulven (hydroxymethylacylfulvene) and analogues  Academic Article
  • Synthesis and evaluation of a thio analogue of duocarmycin SA  Academic Article
  • Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one alkylation subunit  Academic Article
  • Toward antibody-directed ''abzyme'' prodrug therapy, adapt: Carbamate prodrug activation by a catalytic antibody and its in vitro application to human tumor cell killing  Academic Article
  • Tumor efficacy and bone marrow-sparing properties of TER286, a cytotoxin activated by glutathione S-transferase  Academic Article

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