subject area of
- A combination of low-dose cyclophosphamide and colony-stimulating factors is more cost-effective than granulocyte-colony-stimulating factors alone in mobilizing peripheral blood stem and progenitor cells Academic Article
- A fundamental relationship between hydrophobic properties and biological activity for the duocarmycin class of DNA-alkylating antitumor drugs: hydrophobic-binding-driven bonding Academic Article
- Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin Academic Article
- Arresting cancer proliferation by small-molecule gene regulation Academic Article
- Bifunctional alkylating agents derived from duocarmycin SA: Potent antitumor activity with altered sequence selectivity Academic Article
- CBI-CDPBO1 and CBI-CDPBI1 - CC-1065 analogs containing deep-seated modifications in the DNA-binding subunit Academic Article
- Characterization of a side population of astrocytoma cells in response to temozolomide Academic Article
- Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells Academic Article
- Design, synthesis, and evaluation of duocarmycin O-amino phenol prodrugs subject to tunable reductive activation Academic Article
- Discrete roles of the Spc1 kinase and the Atf1 transcription factor in the UV response of Schizosaccharomyces pombe Academic Article
- Growth arrest of BCR-ABL positive cells with a sequence-specific polyamide-chlorambucil conjugate Academic Article
- High resolution solution structure of a DNA duplex alkylated by the antitumor agent duocarmycin SA Academic Article
- Mass spectrometry-based quantification of the cellular response to methyl methanesulfonate treatment in human cells Academic Article
- Mechanisms of in situ activation for DNA-targeting antitumor agents Academic Article
- Modulation of the maladaptive stress response to manage diseases of protein folding Academic Article
- Molecular evolution of Theta-class glutathione transferase for enhanced activity with the anticancer drug 1,3-bis-(2-chloroethyl)-1-nitrosourea and other alkylating agents Academic Article
- NMR structure of the (+)-CPI-indole/d(GACTAATTGAC)-d(GTCAATTAGTC) covalent complex Academic Article
- Potent activity against K562 cells by polyamide-seco-CBI conjugates targeting histone H4 genes Academic Article
- Resolution of a CPzl precursor, synthesis and biological evaluation of (+) and (-)-NBoc-CPzl: a further validation of the relationship between chemical solvolytic stability and cytotoxicity Academic Article
- Role of O-6-methylguanine-DNA methyltransferase, glutathione transferase M3-3 and glutathione in resistance to carmustine in a human non-small cell lung cancer cell line Academic Article
- Structure-activity studies of antitumor agent irofulven (hydroxymethylacylfulvene) and analogues Academic Article
- Synthesis and evaluation of a thio analogue of duocarmycin SA Academic Article
- Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one alkylation subunit Academic Article
- Toward antibody-directed ''abzyme'' prodrug therapy, adapt: Carbamate prodrug activation by a catalytic antibody and its in vitro application to human tumor cell killing Academic Article
- Tumor efficacy and bone marrow-sparing properties of TER286, a cytotoxin activated by glutathione S-transferase Academic Article