subject area of
- An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a Academic Article
- B cell selection defects underlie the development of diabetogenic apcs in nonobese diabetic mice Academic Article
- B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen Academic Article
- B-cell antigen receptor competence regulates b-lymphocyte selection and survival Academic Article
- Deletion of naive CD8 T cells requires persistent antigen and is not programmed by an initial signal from the tolerogenic APC Academic Article
- Developmental regulation of b lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection Academic Article
- Distinct requirements for deletion versus anergy during CD8 T cell peripheral tolerance in vivo Academic Article
- Efficient peripheral clonal elimination of b lymphocytes in mrl/lpr mice bearing autoantibody transgenes Academic Article
- Enforced bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral b cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature b cells Academic Article
- Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic mice Academic Article
- Functional immunoglobulin transgenes guide ordered b-cell differentiation in rag-1-deficient mice Academic Article
- Heavy chain V gene-specific elimination of B cells during the pre-B cell to B cell transition Academic Article
- In a transgenic model of spontaneous autoimmune diabetes, expression of a protective class II MHC molecule results in thymic deletion of diabetogenic CD8+ T cells Academic Article
- Liver-expressed Igκ superantigen induces tolerance of polyclonal B cells by clonal deletion not κ to λ receptor editing Academic Article
- Maternal b lymphocytes specific for paternal histocompatibility antigens are partially deleted during pregnancy Academic Article
- Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1d Academic Article
- Negative selection assay based on stimulation of t cell receptor transgenic thymocytes with peptide-mhc tetramers Academic Article
- Negative selection of T cells occurs throughout thymic development Academic Article
- Peripheral deletion of CD8 T cells requires p38 MAPK in cross-presenting dendritic cells Academic Article
- Phenotypic and functional analysis of CD8(+) T cells undergoing peripheral deletion in response to cross-presentation of self-antigen Academic Article
- Preferential escape of subdominant cd8(+) t cells during negative selection results in an altered antiviral t cell hierarchy Academic Article
- Selection of aberrant class II restricted CD8(+) T cells in NOD mice expressing a glutamic acid decarboxylase (GAD) 65-specific T cell receptor transgene Academic Article
- Split tolerance in peripheral B cell subsets in mice expressing a low level of Ig kappa-reactive ligand Academic Article
- T cell receptor (tcr)-induced death of immature cd4(+)cd8(+) thymocytes by two distinct mechanisms differing in their requirement for cd28 costimulation: Implications for negative selection in the thymus Academic Article
- T cell-independent rescue of b lymphocytes from peripheral immune tolerance Academic Article
- T-cell apoptosis detected in-situ during positive and negative selection in the thymus Academic Article
- The T-cell repertoire available for recognition of self-antigens Academic Article
- The apoptotic pathway contributing to the deletion of naive CD8 T cells during the induction of peripheral tolerance to a cross-presented self-antigen Academic Article