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Clonal Deletion

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  • An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a  Academic Article
  • B cell selection defects underlie the development of diabetogenic apcs in nonobese diabetic mice  Academic Article
  • B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen  Academic Article
  • B-cell antigen receptor competence regulates b-lymphocyte selection and survival  Academic Article
  • Deletion of naive CD8 T cells requires persistent antigen and is not programmed by an initial signal from the tolerogenic APC  Academic Article
  • Developmental regulation of b lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection  Academic Article
  • Distinct requirements for deletion versus anergy during CD8 T cell peripheral tolerance in vivo  Academic Article
  • Efficient peripheral clonal elimination of b lymphocytes in mrl/lpr mice bearing autoantibody transgenes  Academic Article
  • Enforced bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral b cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature b cells  Academic Article
  • Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic mice  Academic Article
  • Functional immunoglobulin transgenes guide ordered b-cell differentiation in rag-1-deficient mice  Academic Article
  • Heavy chain V gene-specific elimination of B cells during the pre-B cell to B cell transition  Academic Article
  • In a transgenic model of spontaneous autoimmune diabetes, expression of a protective class II MHC molecule results in thymic deletion of diabetogenic CD8+ T cells  Academic Article
  • Liver-expressed Igκ superantigen induces tolerance of polyclonal B cells by clonal deletion not κ to λ receptor editing  Academic Article
  • Maternal b lymphocytes specific for paternal histocompatibility antigens are partially deleted during pregnancy  Academic Article
  • Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1d  Academic Article
  • Negative selection assay based on stimulation of t cell receptor transgenic thymocytes with peptide-mhc tetramers  Academic Article
  • Negative selection of T cells occurs throughout thymic development  Academic Article
  • Peripheral deletion of CD8 T cells requires p38 MAPK in cross-presenting dendritic cells  Academic Article
  • Phenotypic and functional analysis of CD8(+) T cells undergoing peripheral deletion in response to cross-presentation of self-antigen  Academic Article
  • Preferential escape of subdominant cd8(+) t cells during negative selection results in an altered antiviral t cell hierarchy  Academic Article
  • Selection of aberrant class II restricted CD8(+) T cells in NOD mice expressing a glutamic acid decarboxylase (GAD) 65-specific T cell receptor transgene  Academic Article
  • Split tolerance in peripheral B cell subsets in mice expressing a low level of Ig kappa-reactive ligand  Academic Article
  • T cell receptor (tcr)-induced death of immature cd4(+)cd8(+) thymocytes by two distinct mechanisms differing in their requirement for cd28 costimulation: Implications for negative selection in the thymus  Academic Article
  • T cell-independent rescue of b lymphocytes from peripheral immune tolerance  Academic Article
  • T-cell apoptosis detected in-situ during positive and negative selection in the thymus  Academic Article
  • The T-cell repertoire available for recognition of self-antigens  Academic Article
  • The apoptotic pathway contributing to the deletion of naive CD8 T cells during the induction of peripheral tolerance to a cross-presented self-antigen  Academic Article

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