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Tetrahydrofolates

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  • 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase  Academic Article
  • 10-formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway  Academic Article
  • Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase  Academic Article
  • Chemical expansion of cofactor activity  Academic Article
  • Cofactor-mediated conformational dynamics promote product release from Escherichia coli dihydrofolate reductase via an allosteric pathway  Academic Article
  • Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle  Academic Article
  • Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates  Academic Article
  • Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway  Academic Article
  • Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway  Academic Article
  • Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase  Academic Article
  • Functional-role of a mobile loop of escherichia-coli dihydrofolate-reductase in transition-state stabilization  Academic Article
  • Identification of endogenous ligands bound to bacterially expressed human and E. coli dihydrofolate reductase by 2D NMR  Academic Article
  • Interaction of 5-methyltetrahydrofolate and tetrahydrobiopterin on endothelial function  Academic Article
  • Millisecond timescale fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands  Academic Article
  • Mitochondrial one-carbon pathway supports cytosolic folate integrity in cancer cells  Academic Article
  • Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid  Academic Article
  • Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency  Academic Article
  • Structure of avian aicar transformylase with a multisubstrate adduct inhibitor β-DADF identifies the folate binding site  Academic Article
  • Synthesis and biological evaluation of α- and γ-carboxamide derivatives of 10-CF3CO-DDACTHF  Academic Article
  • Synthesis of nitric oxide by the nos-like protein from deinococcus radiodurans: A direct role for tetrahydrofolate  Academic Article
  • The dynamic energy landscape of dihydrofolate reductase catalysis  Academic Article
  • The stereochemistry of pyridoxal phosphate enzymes. The absolute stereochemistry of cofactor c' 4 protonation in the transamination of holoserine hydroxymethylase by d-alanine  Academic Article

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