subject area of
- 3,5-disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors Academic Article
- A new regulatory switch in a JAK protein kinase Academic Article
- Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum: Role of β-haematin inhibition and drug concentration in vacuolar water- and lipid-phases Academic Article
- Chemoproteomics demonstrates target engagement and exquisite selectivity of the clinical phosphodiesterase 10A inhibitor MP-10 in its native environment Academic Article
- Combination therapy targeting both tumor-initiating and differentiated cell populations in prostate carcinoma Academic Article
- Conformation-induced remote meta-C-H activation of amines Academic Article
- Congenital myopathy-causing tropomyosin mutations induce thin filament dysfunction via distinct physiological mechanisms Academic Article
- D3 receptor test in vitro predicts decreased cocaine self-administration in rats Academic Article
- Design, synthesis, and evaluation of novel 3,6-diaryl-4-aminoalkoxyquinolines as selective agonists of somatostatin receptor subtype 2 Academic Article
- Determinants of cytochrome P4502C8 substrate binding - structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid Academic Article
- Discovery and SAR of muscarinic receptor subtype 1 (M-1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-Dibenzyl-2H-pyrazolo 4,3-c quinolin-3(5H)-ones as positive allosteric modulators Academic Article
- Discovery of a drug candidate for GLIS3-associated diabetes Academic Article
- Divergent total syntheses of (-)-aspidospermine and (+)-spegazzinine Academic Article
- Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction - a randomized trial Academic Article
- Effects of the slco1b1*15 allele on the pharmacokinetics of pitavastatin Academic Article
- Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors Academic Article
- Golgicide A reveals essential roles for GBF1 in Golgi assembly and function Academic Article
- How thiostrepton was made in the laboratory Academic Article
- IL-7/anti-IL-7 mAb complexes augment cytokine potency in mice through association with IgG-Fc and by competition with IL-7R Academic Article
- Induction of avian tumor viruses in normal cells by physical and chemical carcinogens Academic Article
- Inhibition of dsRNA-induced signaling in hepatitis C virus-infected cells by NS3 protease-dependent and -independent mechanisms Academic Article
- Inhibitors of c-jun-n-terminal kinase (jnk) Academic Article
- Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation Academic Article
- Integrated hydrogenated amorphous Si photodiode detector for microfluidic bioanalytical devices Academic Article
- Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials Academic Article
- Ligand-controlled C(sp(3))-H arylation and olefination in synthesis of unnatural chiral alpha-amino acids Academic Article
- Ligand-enabled gamma-C-H olefination and carbonylation: construction of beta-quaternary carbon centers Academic Article
- Ligand-enabled methylene C(sp3)-H bond activation with a Pd(II) catalyst Academic Article
- Marginal utility of montelukast for persistent asthma Academic Article
- Neurochemical evidence that postsynaptic nucleus accumbens D3 receptor stimulation enhances cocaine reinforcement Academic Article
- New class of HIV-1 integrase (IN) inhibitors with a dual mode of action Academic Article
- New diarylmethylpiperazines as potent and selective nonpeptidic delta opioid receptor agonists with increased in vitro metabolic stability Academic Article
- Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators Academic Article
- Pd0/PR3-catalyzed arylation of nicotinic and isonicotinic acid derivatives Academic Article
- Pharmacological and behavioral profile of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-chinolincarboxamide (EVP-5141), a novel α7 nicotinic acetylcholine receptor agonist/serotonin 5-HT3 receptor antagonist Academic Article
- Phosphodiesterase 10A regulates alcohol and saccharin self-administration in rats Academic Article
- Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: discovery and structure-activity relationships of a series of quinoline and quinoxaline derivatives Academic Article
- Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured plasmodium falciparum parasites Academic Article
- Quinelorane, a dopamine D3/D2 receptor agonist, reduces prepulse inhibition of startle and ventral pallidal GABA efflux: time course studies Academic Article
- S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species Academic Article
- Screening helix-threading peptides for RNA binding using a thiazole orange displacement assay Academic Article
- Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2) Academic Article
- Stereocontrolled synthesis of the quinaldic acid macrocyclic system of thiostrepton Academic Article
- Streptonigrin and lavendamycin partial structures - probes for the minimum, potent pharmacophore of streptonigrin, lavendamycin, and synthetic quinoline-5,8-diones Academic Article
- Structure-activity relationships of imidazo[4,5-f]quinoline partial structures and analogs. Discovery of pyrazolo[3,4-f]quinoline derivatives as potent immunostimulants Academic Article
- Synthesis of artemiside and its effects in combination with conventional drugs against severe murine malaria. Academic Article
- Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds Academic Article
- The PI3K/Akt pathway contributes to arenavirus budding Academic Article
- Thiazole orange as the fluorescent intercalator in a high resolution fid assay for determining DNA binding affinity and sequence selectivity of small molecules Academic Article
- Total synthesis of thiostrepton, part 2: Construction of the quinaldic acid macrocycle and final stages of the synthesis Academic Article