subject area of

• A new class of highly cytotoxic diketopiperazines  Academic Article
• A unique class of duocarmycin and CC-1065 analogues subject to reductive activation  Academic Article
• Assessment of solution-phase positional scanning libraries based on distamycin A for the discovery of new DNA binding agents  Academic Article
• Bifunctional alkylating agents derived from duocarmycin SA: Potent antitumor activity with altered sequence selectivity  Academic Article
• CC-1065/duocarmycin and bleomycin A(2) hybrid agents: lack of enhancement of DNA alkylation by attachment to noncomplementary DNA binding subunits  Academic Article
• Design, synthesis and evaluation of bouvardin, deoxybouvardin and RA-I-XIV pharmacophore analogs  Academic Article
• Design, synthesis, and evaluation of duocarmycin O-amino phenol prodrugs subject to tunable reductive activation  Academic Article
• Efficacious cyclic N-acyl O-amino phenol duocarmycin prodrugs  Academic Article
• Establishing the parabolic relationship between reactivity and activity for derivatives and analogues of the duocarmycin and CC-1065 alkylation subunits  Academic Article
• Expression of h-2 antigens during growth of cultured tumor cells  Academic Article
• Metal cation complexation and activation of reversed CPyi analogues of CC-1065 and duocarmycin SA: Partitioning the effects of binding and catalysis  Academic Article
• Resolution of a CPzl precursor, synthesis and biological evaluation of (+) and (-)-NBoc-CPzl: a further validation of the relationship between chemical solvolytic stability and cytotoxicity  Academic Article
• Streptonigrin and lavendamycin partial structures - probes for the minimum, potent pharmacophore of streptonigrin, lavendamycin, and synthetic quinoline-5,8-diones  Academic Article
• Synthesis and antitumor activities of unsymmetrically substituted 1,4-bis (aminoalkyl)amino anthracene-9,10-diones and related systems  Academic Article
• Synthesis and evaluation of a series of C3-substituted CBI analogues of CC-1065 and the duocarmycins  Academic Article
• Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one alkylation subunit  Academic Article
• Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: Impact on PP2A inhibition  Academic Article
• Total synthesis of ningalin D  Academic Article