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Diabetes Mellitus, Experimental

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  • A viral epitope that mimics a self antigen can accelerate but nit initiate autoimmune diabetes  Academic Article
  • Abrogation of diabetes in bb rats by acute virus-infection - association of viral-lymphocyte interactions  Academic Article
  • Activated protein C preserves functional islet mass after intraportal transplantation - a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death  Academic Article
  • Activation of the liver x receptor increases neuroactive steroid levels and protects from diabetes-induced peripheral neuropathy  Academic Article
  • Adenovirus e3 mhc inhibitory genes but not tnf/fas apoptotic inhibitory genes expressed in beta cells prevent autoimmune diabetes  Academic Article
  • Altered functional and biochemical response by CD8+ T cells that remain after tolerance  Academic Article
  • Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPAR gamma by Cdk5  Academic Article
  • Autoimmune diabetes can be induced in transgenic major histocompatibility complex class-ii-deficient mice  Academic Article
  • Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates streptozotocin-induced apoptosis of pancreatic beta-cells  Academic Article
  • Bone marrow as an alternative site for islet transplantation  Academic Article
  • CD8(+) T cell-mediated spontaneous diabetes in neonatal mice  Academic Article
  • Characterization of CD8+ T lymphocytes that persist after peripheral tolerance to a self antigen expressed in the pancreas  Academic Article
  • Dendritic cells transduced to express interleukin-4 prevent diabetes in nonobese diabetic mice with advanced insulitis  Academic Article
  • Design, synthesis and SAR of novel glucokinase activators  Academic Article
  • Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1  Academic Article
  • Diabetes-induced myelin abnormalities are associated with an altered lipid pattern: Protective effects of lxr activation  Academic Article
  • Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators  Academic Article
  • DsAAV8-mediated expression of glucagon-like peptide-1 in pancreatic beta-cells ameliorates streptozotocin-induced diabetes  Academic Article
  • DsAAV8-mediated gene transfer and beta-cell expression of IL-4 and beta-cell growth factors are capable of reversing early-onset diabetes in NOD mice  Academic Article
  • Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes  Academic Article
  • Erythropoietin for neurologic protection and diabetic neuropathy  Academic Article
  • Exploring stem cell biology with small molecules  Academic Article
  • Gene transfer of manganese superoxide dismutase extends islet graft function in a mouse model of autoimmune diabetes  Academic Article
  • How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model  Academic Article
  • Human pancreatic beta-like cells converted from fibroblasts  Academic Article
  • Identification of a small molecular insulin receptor agonist with potent antidiabetes activity  Academic Article
  • In vivo expression of HGF/NK1 and GLP-1 from dsAAV vectors enhances pancreatic beta-cell proliferation and improves pathology in the db/db mouse model of diabetes  Academic Article
  • Increased expression of thrombospondin-1 in vessel wall of diabetic zucker rat  Academic Article
  • Inhibition of diabetes in bb rats by virus-infection  Academic Article
  • Inhibition of diabetes in bb rats by virus-infection .2. Effect of virus-infection on the immune-response to nonviral and viral-antigens  Academic Article
  • Insulinoma-released exosomes activate autoreactive marginal zone-like B cells that expand endogenously in prediabetic NOD mice  Academic Article
  • Insulinoma-released exosomes or microparticles are immunostimulatory and can activate autoreactive T cells spontaneously developed in nonobese diabetic mice  Academic Article
  • Knockout of toll-like receptor-2 attenuates both the proinflammatory state of diabetes and incipient diabetic nephropathy  Academic Article
  • Knockout of toll-like receptor-4 attenuates the pro-inflammatory state of diabetes  Academic Article
  • Long-term studies of pancreas allotransplantation in experimental diabetes mellitus  Academic Article
  • Lysophosphatidic acid regulates blood glucose by stimulating myotube and adipocyte glucose uptake  Academic Article
  • Lysophosphatidylcholine activates adipocyte glucose uptake and lowers blood glucose levels in murine models of diabetes  Academic Article
  • Lysophosphatidylserine regulates blood glucose by enhancing glucose transport in myotubes and adipocytes  Academic Article
  • Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota  Academic Article
  • Modulation of dynamin-related protein 1 (DRP1) function by increased O-linked-beta-N-acetylglucosamine modification (O-GlcNAc) in cardiac myocytes  Academic Article
  • Molecular anatomy and number of antigen specific CD8 T cells required to cause type 1 diabetes  Academic Article
  • Neointimal hyperplasia after arterial injury is increased in a rat model of non-insulin-dependent diabetes mellitus  Academic Article
  • Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects  Academic Article
  • Oral insulin (human, murine, or porcine) does not prevent diabetes in the non-obese diabetic mouse  Academic Article
  • Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice  Academic Article
  • Pancreatic beta-cell neogenesis by direct conversion from mature alpha-cells  Academic Article
  • Peroxisome proliferator-activated receptor gamma down-regulates receptor for advanced glycation end products and inhibits smooth muscle cell proliferation in a diabetic and nondiabetic rat carotid artery injury model  Academic Article
  • Persistent virus infection associated with chemical manifestations of diabetes. II. Role of viral strain, environmental insult, and host genetics  Academic Article
  • Prevention of type-i diabetes in nonobese diabetic mice by virus-infection  Academic Article
  • Renin-angiotensin system blockade prevents the increase in plasma transforming growth factor beta(1), and reduces proteinuria and kidney hypertrophy in the streptozotocin-diabetic rat  Academic Article
  • Switching-on survival and repair response programs in islet transplants by bone marrow-derived vasculogenic cells  Academic Article
  • Tcr affinity and negative regulation limit autoimmunity  Academic Article
  • The diabetogenic mouse MHC class II molecule I-A(g7) is endowed with a switch that modulates TCR affinity  Academic Article
  • The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats  Academic Article
  • Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages  Academic Article
  • Virus persists in beta-cells of islets of langerhans and infection is associated with chemical manifestations of diabetes .2. Morphologic observations  Academic Article
  • Virus-infection triggers insulin-dependent diabetes-mellitus in a transgenic model - role of anti-self (virus) immune-response  Academic Article

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