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Regulation of p53 stability and apoptosis by a ROR agonist

Academic Article
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Overview

authors

  • Wang, Y. J.
  • Solt, Laura A.
  • Kojetin, Douglas
  • Burris, Thomas

publication date

  • April 2012

journal

  • PLoS One  Journal

abstract

  • Activation of p53 function leading to cell-cycle arrest and/or apoptosis is a promising strategy for development of anti-cancer therapeutic agents. Here, we describe a novel mechanism for stabilization of p53 protein expression via activation of the orphan nuclear receptor, RORα. We demonstrate that treatment of cancer cells with a newly described synthetic ROR agonist, SR1078, leads to p53 stabilization and induction of apoptosis. These data suggest that synthetic ROR agonists may hold utility in the treatment of cancer.

subject areas

  • Antineoplastic Agents
  • Apoptosis
  • Benzamides
  • Cell Cycle
  • Gene Expression Regulation, Neoplastic
  • Hep G2 Cells
  • Humans
  • Nuclear Receptor Subfamily 1, Group F, Member 1
  • SOXC Transcription Factors
  • Tumor Suppressor Protein p53
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Identity

PubMed Central ID

  • PMC3324542

International Standard Serial Number (ISSN)

  • 1932-6203

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0034921

PubMed ID

  • 22509368
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Additional Document Info

start page

  • e34921

volume

  • 7

issue

  • 4

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