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Merlin in organ size control and tumorigenesis: Hippo versus EGFR?

Academic Article
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Overview

authors

  • Yi, C. L.
  • Kissil, Joseph

publication date

  • August 2010

journal

  • Genes & Development  Journal

abstract

  • The role of the NF2 gene as a tumor suppressor has been well established. In this issue of Genes & Development, Benhamouche and colleagues (pp. 1718-1730) demonstrate that NF2 is also involved in the regulation of organ size control in mammals. Conditional knockout of Nf2 in the mouse liver results in massive organ enlargement and eventual tumor development, which is attributed to the specific expansion of oval cells. Here we discuss these findings and the proposed molecular mechanisms involved within the context of our current understanding of the pathways regulated by NF2.

subject areas

  • Animals
  • Disease Models, Animal
  • Humans
  • Mice
  • Neurofibromatosis 2
  • Neurofibromin 2
  • Organ Size
  • Protein-Serine-Threonine Kinases
  • Receptor, Epidermal Growth Factor
  • Signal Transduction
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Research

keywords

  • EGFR
  • Merlin
  • NF2
  • cholangiocellular carcinoma
  • hepatocellular carcinoma
  • liver progenitor
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Identity

PubMed Central ID

  • PMC2922497

International Standard Serial Number (ISSN)

  • 0890-9369

Digital Object Identifier (DOI)

  • 10.1101/gad.1964810

PubMed ID

  • 20713513
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Additional Document Info

start page

  • 1673

end page

  • 1679

volume

  • 24

issue

  • 16

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