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The Mohawk homeobox gene is a critical regulator of tendon differentiation

Academic Article
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Overview

authors

  • Ito, Y.
  • Toriuchi, N.
  • Yoshitaka, T.
  • Ueno-Kudoh, H.
  • Sato, T.
  • Yokoyama, S.
  • Nishida, K.
  • Akimoto, T.
  • Takahashi, M.
  • Miyaki, S.
  • Asahara, Hiroshi

publication date

  • June 2010

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • Mohawk (Mkx) is a member of the Three Amino acid Loop Extension superclass of atypical homeobox genes that is expressed in developing tendons. To investigate the in vivo functions of Mkx, we generated Mkx(-/-) mice. These mice had hypoplastic tendons throughout the body. Despite the reduction in tendon mass, the cell number in tail tendon fiber bundles was similar between wild-type and Mkx(-/-) mice. We also observed small collagen fibril diameters and a down-regulation of type I collagen in Mkx(-/-) tendons. These data indicate that Mkx plays a critical role in tendon differentiation by regulating type I collagen production in tendon cells.

subject areas

  • Animals
  • Cell Differentiation
  • Collagen Type I
  • Gene Expression Regulation, Developmental
  • Homeodomain Proteins
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Microscopy, Electron, Transmission
  • Tendons
  • Tensile Strength
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Identity

PubMed Central ID

  • PMC2890854

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.1000525107

PubMed ID

  • 20498044
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Additional Document Info

start page

  • 10538

end page

  • 10542

volume

  • 107

issue

  • 23

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