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Gene therapy in transplantation

Academic Article
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Overview

authors

  • Giannoukakis, N.
  • Thomson, A. W.
  • Robbins, Paul D.

publication date

  • September 1999

journal

  • Gene Therapy  Journal

abstract

  • Facilitation of solid organ and cell transplantation depends on metabolic and immunologic factors that can be manipulated ex vivo and in vivo using gene transfer technology. Vectors have been developed which can optimally transfer relevant genes to various tissues and organs. Interventions aimed at promoting tissue preservation before transplantation, prevention of oxidative stress and immunological rejection have recently become attractive options using viral and nonviral gene delivery vehicles. Further understanding of the mechanisms involved in tolerance induction as well as the facilitation of xenogeneic engraftment have made possible a variety of avenues that can be exploited using gene transfer technology.

subject areas

  • Animals
  • Apoptosis
  • Dendritic Cells
  • Gene Targeting
  • Gene Transfer Techniques
  • Genetic Therapy
  • Genetic Vectors
  • Graft Rejection
  • Humans
  • Immunosuppression
  • Reperfusion Injury
  • Transplantation Immunology
  • Transplantation, Heterologous
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Research

keywords

  • allograft
  • gene therapy tolerance
  • rejection
  • transplantation
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Identity

International Standard Serial Number (ISSN)

  • 0969-7128

Digital Object Identifier (DOI)

  • 10.1038/sj.gt.3300981

PubMed ID

  • 10490759
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Additional Document Info

start page

  • 1499

end page

  • 1511

volume

  • 6

issue

  • 9

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