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Endogenous opioids in frontal cortex of patients with down syndrome

Academic Article
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Overview

authors

  • Risser, D.
  • You, Z. B.
  • Cairns, N.
  • HerreraMarschitz, M.
  • Seidl, R.
  • Schneider, C.
  • Terenius, Lars
  • Lubec, G.

publication date

  • January 1996

journal

  • Neuroscience Letters  Journal

abstract

  • The main purpose of this study was to investigate differences regarding endogenous opioids in post-mortem frontal cortex of adult patients with Down syndrome (DS), patients with Alzheimer disease (AD) and neurologically healthy persons, respectively, using specific radioimmunoassays. The results of this study show that there is an increase in the levels of leu-enkephalin and dynorphin A in the frontal cortex of patients with DS as compared to the control group. An almost identical increase was also observed when comparing patients with AD to controls. In conclusion, the results of this study suggest a relationship between elevated tissue levels of leuenkephalin and dynorphin A in cerebral cortex and cognitive impairments in patients with DS and AD.

subject areas

  • Aged
  • Alzheimer Disease
  • Down Syndrome
  • Dynorphins
  • Endorphins
  • Enkephalin, Leucine
  • Enkephalin, Methionine
  • Enkephalins
  • Female
  • Frontal Lobe
  • Gene Expression Regulation
  • Humans
  • Male
  • Middle Aged
  • Protein Precursors
  • Radioimmunoassay
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Research

keywords

  • Alzheimer disease
  • Down syndrome
  • dynorphin
  • enkephalin
  • frontal cortex
  • radioimmunoassay
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Identity

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/0304-3940(95)12275-3

PubMed ID

  • 8834106
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Additional Document Info

start page

  • 111

end page

  • 114

volume

  • 203

issue

  • 2

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