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The roles of tumor-derived exosomes in cancer pathogenesis

Academic Article
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Overview

authors

  • Yang, C. J.
  • Robbins, Paul D.

publication date

  • 2011

journal

  • Clinical & Developmental Immunology  Journal

abstract

  • Exosomes are endosome-derived, 30-100 nm small membrane vesicles released by most cell types including tumor cells. They are enriched in a selective repertoire of proteins and nucleic acids from parental cells and are thought to be actively involved in conferring intercellular signals. Tumor-derived exosomes have been viewed as a source of tumor antigens that can be used to induce antitumor immune responses. However, tumor-derived exosomes also have been found to possess immunosuppressive properties and are able to facilitate tumor growth, metastasis, and the development of drug resistance. These different effects of tumor-derived exosomes contribute to the pathogenesis of cancer. This review will discuss the roles of tumor-derived exosomes in cancer pathogenesis, therapy, and diagnostics.

subject areas

  • Animals
  • Antigens, Neoplasm
  • Exosomes
  • Humans
  • Neoplasms
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Identity

PubMed Central ID

  • PMC3235485

International Standard Serial Number (ISSN)

  • 1740-2522

Digital Object Identifier (DOI)

  • 10.1155/2011/842849

PubMed ID

  • 22190973
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Additional Document Info

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  • 842849

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