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Evidence that hi-terminal fragments of nociceptin modulate nociceptin-induced scratching, biting and licking in mice

Academic Article
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Overview

authors

  • Sakurada, T.
  • Sakurada, S.
  • Katsuyama, S.
  • Hayashi, T.
  • Sakurada, C.
  • Tan-No, K.
  • Johansson, H.
  • Sandin, J.
  • Terenius, Lars

publication date

  • January 2000

journal

  • Neuroscience Letters  Journal

abstract

  • The intrathecal (i.t.) injection of 3.0 fmol nociceptin (orphanin FQ) elicited scratching, biting and licking responses in mice. N-terminal fragments of nociceptin, nociceptin (1-7), nociceptin (1-9) and nociceptin (1-13), induced no characteristic behavioral response. When these N-terminal fragments of nociceptin were injected simultaneously with nociceptin, the behavioral response induced by nociceptin was reduced dose-dependently. Nociceptin (1-13) was much more potent than nociceptin (1-7) and nociceptin (1-9) and antagonized nociceptin-induced response at equimolar doses. No significant effects of the N-terminal fragments were observed against the scratching, biting and licking response elicited by i.t. administration of substance P or N-methyl-D-aspartate. These results suggest that N-terminal fragments formed endogenously in the spinal cord may have an antagonistic effect on nociceptin-induced behavioral responses.

subject areas

  • Animals
  • Bites and Stings
  • Grooming
  • Male
  • Mice
  • Nociceptors
  • Opioid Peptides
  • Peptide Fragments
  • Pruritus
  • Spinal Cord
  • Vasodilator Agents
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Research

keywords

  • irritant
  • mouse
  • nociceptin
  • nociceptin N-terminal fragments
  • spinal cord
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Identity

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/s0304-3940(99)00958-1

PubMed ID

  • 10670788
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Additional Document Info

start page

  • 61

end page

  • 64

volume

  • 279

issue

  • 1

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