recent publications
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academic article
- Reay, J., Gambotto, A., Robbins, P. D. The antitumor effects of adenoviral-mediated, intratumoral delivery of interleukin 23 require endogenous IL-12 Cancer Gene Therapy 2012 19:135-143 DOI:10.1038/cgt.2011.78 PMID:22158522 PMCID:PMC3508719
- Barba, M., Pirozzi, F., Saulnier, N., Vitali, T., Natale, M. T., Logroscino, G., Robbins, P. D., Gambotto, A., Neri, G., Michetti, F., Pola, E., Lattanzi, W. Lim mineralization protein 3 induces the osteogenic differentiation of human amniotic fluid stromal cells through kruppel-like factor-4 downregulation and further bone-specific gene expression Journal of Biomedicine and Biotechnology 2012 813894 DOI:10.1155/2012/813894 PMID:23097599 PMCID:PMC3471036
- Bernardini, C., Saulnier, N., Parrilla, C., Pola, E., Gambotto, A., Michetti, F., Robbins, P. D., Lattanzi, W. Early transcriptional events during osteogenic differentiation of human bone marrow stromal cells induced by Lim mineralization protein 3 Gene Expression 2010 15:27-42 DOI:10.3727/105221610x12819686555097 PMID:21061915
- Lattanzi, W., Parrilla, C., Fetoni, A., Logroscino, G., Straface, G., Pecorini, G., Stigliano, E., Tampieri, A., Bedini, R., Pecci, R., Michetti, F., Gambotto, A., et al. Ex vivo-transduced autologous skin fibroblasts expressing human Lim mineralization protein-3 efficiently form new bone in animal models Gene Therapy 2008 15:1330-1343 DOI:10.1038/gt.2008.116 PMID:18633445 PMCID:PMC3488859
- Rehman, K. K., Bertera, S., Trucco, M., Gambotto, A., Robbins, P. D. Immunomodulation by adenoviral-mediated SCD40-Ig gene therapy for mouse allogeneic islet transplantation Transplantation 2007 84:301-307 DOI:10.1097/01.tp.0000275183.50435.b6 PMID:17700153
- Gao, W. T., Soloff, A. C., Lu, X. H., Montecalvo, A., Nguyen, D. C., Matsuoka, Y., Robbins, P. D., Swayne, D. E., Donis, R. O., Katz, J. M., Barratt-Boyes, S. M., Gambotto, A. Protection of mice and poultry from lethal H5N1 avian influenza virus through adenovirus-based immunization Journal of Virology 2006 80:1959-1964 DOI:10.1128/jvi.80.4.1959-1964.2006 PMID:16439551
- Barratt-Boyes, S. M., Soloff, A. C., Gao, W. T., Nwanegbo, E., Liu, X. D., Rajakumar, P. A., Brown, K. N., Robbins, P. D., Murphey-Corb, M., Day, R. D., Gambotto, A. Broad cellular immunity with robust memory responses to simian immunodeficiency virus following serial vaccination with adenovirus 5-and 35-based vectors Journal of General Virology 2006 87:139-149 DOI:10.1099/vir.0.8.1445-0 PMID:16361426
- Kim, S. H., Lechman, E. R., Bianco, N., Menon, R., Keravala, A., Nash, J., Mi, Z. B., Watkins, S. C., Gambotto, A., Robbins, P. D. Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis Journal of Immunology 2005 174:6440-6448 PMID:15879146
- Pola, E., Gao, W., Zhou, Y., Pola, R., Lattanzi, W., Sfeir, C., Gambotto, A., Robbins, P. Efficient bone formation by gene transfer of human LIM mineralization protein-3 Gene Therapy 2004 11:683-693 DOI:10.1038/sj.gt.3302207 PMID:14724674
- Nwanegbo, E., Vardas, E., Gao, W. T., Whittle, H., Sun, H. J., Rowe, D., Robbins, P. D., Gambotto, A. Prevalence of neutralizing antibodies to adenoviral serotypes 5 and 35 in the adult populations of the Gambia, South Africa, and the United States Clinical and Diagnostic Laboratory Immunology 2004 11:351-357 DOI:10.1128/cdli.11.2.351-357.2004 PMID:15013987
- Gao, W. T., Rzewski, A., Sun, H. J., Robbins, P. D., Gambotto, A. Upgene: Application of a web-based DNA codon optimization algorithm Biotechnology Progress 2004 20:443-448 DOI:10.1021/bp0300467 PMID:15058988
- Gao, W. T., Tamin, A., Soloff, A., D'Aiuto, L., Nwanegbo, E., Robbins, P. D., Bellini, W. J., Barratt-Boyes, S., Gambotto, A. Effects of a SARS-associated coronavirus vaccine in monkeys Lancet 2003 362:1895-1896 DOI:10.1016/s0140-6736(03)14962-8 PMID:14667748
- Gao, W., Robbins, P. D., Gambotto, A. Human adenovirus type 35: nucleotide sequence and vector development Gene Therapy 2003 10:1941-1949 DOI:10.1038/sj.gt.3302097 PMID:14528318
- Tatsumi, T., Huang, J., Gooding, W. E., Gambotto, A., Robbins, P. D., Vujanovic, N. L., Alber, S. M., Watkins, S. C., Okada, H., Storkus, W. J. Intratumoral delivery of dendritic cells engineered to secrete both interleukin (IL)-12 and IL-18 effectively treats local and distant disease in association with broadly reactive Tc1-type immunity Cancer Research 2003 63:6378-6386 PMID:14559827
- Yao, Q., Wang, S., Gambotto, A., Glorioso, J. C., Evans, C. H., Robbins, P. D., Ghivizzani, S. C., Oligino, T. J. Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium Gene Therapy 2003 10:1055-1060 DOI:10.1038/sj.gt.3301881 PMID:12776164
- Feili-Hariri, M., Falkner, D. H., Gambotto, A., Papworth, G. D., Watkins, S. C., Robbins, P. D., Morel, P. A. Dendritic cells transduced to express interleukin-4 prevent diabetes in nonobese diabetic mice with advanced insulitis Human Gene Therapy 2003 14:13-23 DOI:10.1089/10430340360464679 PMID:12573055
- Gao, W. T., Kumar, S., Lotze, M. T., Hanning, C., Robbins, P. D., Gambotto, A. Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity Journal of Immunology 2003 170:107-113 PMID:12496389
- Tourkova, I. L., Yurkovetsky, Z. R., Gambotto, A., Makarenkova, V. P., Perez, L., Balkir, L., Robbins, P. D., Shurin, M. R., Shurin, G. V. Increased function and survival of IL-15-transduced human dendritic cells are mediated by up-regulation of IL-15R alpha and Bcl-2 Journal of Leukocyte Biology 2002 72:1037-1045 PMID:12429727
- Tatsumi, T., Gambotto, A., Robbins, P. D., Storkus, W. J. Interleukin 18 gene transfer expands the repertoire of antitumor Th1-type immunity elicited by dendritic cell-based vaccines in association with enhanced therapeutic efficacy Cancer Research 2002 62:5853-5858 PMID:12384548
- Gambotto, A., Dworacki, G., Cicinnati, V., Kenniston, T., Steitz, J., Tuting, T., Robbins, P. D., DeLeo, A. B. Immunogenicity of enhanced green fluorescent protein (EGFP) in BALB/c mice: Identification of an H2-Kd-restricted CTL epitope Gene Therapy 2000 7:2036-2040 DOI:10.1038/sj.gt.3301335 PMID:11175316
- Giannoukakis, N., Mi, Z., Rudert, W. A., Gambotto, A., Trucco, M., Robbins, P. Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor i Gene Therapy 2000 7:2015-2022 DOI:10.1038/sj.gt.3301333 PMID:11175313
- Pirtskhalaishvili, G., Shurin, G. V., Gambotto, A., Esche, C., Wahl, M., Yurkovetsky, Z. R., Robbins, P. D., Shurin, M. R. Transduction of dendritic cells with Bcl-xL increases their resistance to prostate cancer-induced apoptosis and antitumor effect in mice Journal of Immunology 2000 165:1956-1964 PMID:10925278
- Gambotto, A., Cicinnati, V., Robbins, P. D. Genetic approaches for biologic therapy of cancer Drugs of Today 2000 36:25-39 PMID:12879102
- Ranieri, E., Herr, W., Gambotto, A., Olson, W., Rowe, D., Robbins, P. D., Kierstead, L. S., Watkins, S. C., Gesualdo, L., Storkus, W. J. Dendritic cells transduced with an adenovirus vector encoding Epstein-Barr virus latent membrane protein 2B: A new modality for vaccination Journal of Virology 1999 73:10416-10425 PMID:10559360 PMCID:PMC113097
- Tuting, T., Steitz, J., Bruck, J., Gambotto, A., Steinbrink, K., DeLeo, A. B., Robbins, P., Knop, J., Enk, A. H. Dendritic cell-based genetic immunization in mice with a recombinant adenovirus encoding murine TRP2 induces effective anti-melanoma immunity Journal of Gene Medicine 1999 1:400-406 DOI:10.1002/(sici)1521-2254(199911/12)1:6<400::aid-jgm68>3.0.co;2-d PMID:10753065
- Giannoukakis, N., Rudert, W. A., Ghivizzani, S. C., Gambotto, A., Ricordi, C., Trucco, M., Robbins, P. D. Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1 beta-induced b-cell impairment and activation of islet cell apoptosis in vitro Diabetes 1999 48:1730-1736 DOI:10.2337/diabetes.48.9.1730 PMID:10480601
- Giannoukakis, N., Mi, Z., Gambotto, A., Eramo, A., Ricordi, C., Trucco, M., Robbins, P. D. Infection of intact human islets by a lentiviral vector Gene Therapy 1999 6:1545-1551 DOI:10.1038/sj.gt.3300996 PMID:10490763
- Lechman, E. R., Jaffurs, D., Ghivizzani, S. C., Gambotto, A., Kovesdi, I., Mi, Z. B., Evans, C. H., Robbins, P. D. Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees Journal of Immunology 1999 163:2202-2208 PMID:10438962
- Esche, C., Gambotto, A., Satoh, Y., Gerein, V., Robbins, P. D., Watkins, S. C., Lotze, M. T., Shurin, M. R. CD154 inhibits tumor-induced apoptosis in dendritic cells and tumor growth European Journal of Immunology 1999 29:2148-2155 DOI:10.1002/(sici)1521-4141(199907)29:07<2148::aid-immu2148>3.0.co;2-f PMID:10427977
- Osaki, T., Hashimoto, W., Gambotto, A., Okamura, H., Robbins, P. D., Kurimoto, M., Lotze, M. T., Tahara, H. Potent antitumor effects mediated by local expression of the mature form of the interferon-gamma inducing factor, interleukin-18 (IL-18) Gene Therapy 1999 6:808-815 DOI:10.1038/sj.gt.3300908 PMID:10505105
- Lu, L., Gambotto, A., Lee, W. C., Qian, S., Bonham, C. A., Robbins, P. D., Thomson, A. W. Adenoviral delivery of CTLA4ig into myeloid dendritic cells promotes their in vitro tolerogenicity and survival in allogeneic recipients Gene Therapy 1999 6:554-563 DOI:10.1038/sj.gt.3300862 PMID:10476215
- Tuting, T., Gambotto, A., Robbins, P. D., Storkus, W. J., DeLeo, A. B. Co-delivery of T helper 1-biasing cytokine genes enhances the efficacy of gene gun immunization of mice: Studies with the model tumor antigen beta-galactosidase and the BALB/c Meth A p53 tumor-specific antigen Gene Therapy 1999 6:629-636 DOI:10.1038/sj.gt.3300859 PMID:10476222
- Lu, L., Lee, W. C., Gambotto, A., Zhong, C., Robbins, P. D., Qian, S., Fung, J. J., Thomson, A. W. Transduction of dendritic cells with adenoviral vectors encoding ctla4-ig markedly reduces their allostimulatory activity Transplantation Proceedings 1999 31:797-797 DOI:10.1016/s0041-1345(98)01774-6 PMID:10083343
- Lu, L., Lee, W. C., Takayama, T., Qian, S. G., Gambotto, A., Robbins, P. D., Thomson, A. W. Genetic engineering of dendritic cells to express immunosuppressive molecules (viral IL-10, TGF-beta, and CTLA4lg) Journal of Leukocyte Biology 1999 66:293-296 PMID:10449170
- Gambotto, A., Tuting, T., McVey, D. L., Kovesdi, I., Tahara, H., Lotze, M. T., Robbins, P. D. Induction of antitumor immunity by direct intratumoral injection of a recombinant adenovirus vector expressing interleukin-12 Cancer Gene Therapy 1999 6:45-53 DOI:10.1038/sj.cgt.7700013 PMID:10078963
- Tuting, T., Gambotto, A., DeLeo, A., Lotze, M. T., Robbins, P. D., Storkus, W. J. Induction of tumor antigen-specific immunity using plasmid DNA immunization in mice Cancer Gene Therapy 1999 6:73-80 DOI:10.1038/sj.cgt.7700020 PMID:10078966
- Tuting, T., Gambotto, A., Baar, J., Davis, I. D., Storkus, W. J., Zavodny, P. J., Narula, S., Tahara, H., Robbins, P. D., Lotze, M. T. Interferon-alpha gene therapy for cancer: Retroviral transduction of fibroblasts and particle-mediated transfection of tumor cells are both effective strategies for gene delivery in murine tumor models Gene Therapy 1997 4:1053-1060 DOI:10.1038/sj.gt.3300509 PMID:9415311