Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic fever arenaviruses

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Helguera, G.
  • Jemielity, S.
  • Abraham, J.
  • Cordo, S. M.
  • Martinez, M. G.
  • Rodriguez, J. A.
  • Bregni, C.
  • Wang, Jyzj
  • Farzan, Michael
  • Penichet, M. L.
  • Candurra, N. A.
  • Choe, Hyeryun

publication date

  • 2012

journal

  • Journal of Virology  Journal

abstract

  • Five New World (NW) arenaviruses cause human hemorrhagic fevers. Four of these arenaviruses are known to enter cells by binding human transferrin receptor 1 (hTfR1). Here we show that the fifth arenavirus, Chapare virus, similarly uses hTfR1. We also identify an anti-hTfR1 antibody, ch128.1, which efficiently inhibits entry mediated by the glycoproteins of all five viruses, as well as replication of infectious Junín virus. Our data indicate that all NW hemorrhagic fever arenaviruses utilize a common hTfR1 apical-domain epitope and suggest that therapeutic agents targeting this epitope, including ch128.1 itself, can be broadly effective in treating South American hemorrhagic fevers.

subject areas

  • Amino Acid Sequence
  • Animals
  • Antibodies
  • Antigens, CD
  • Arenaviruses, New World
  • Cell Line
  • Down-Regulation
  • Hemorrhagic Fevers, Viral
  • Humans
  • Molecular Sequence Data
  • Protein Structure, Tertiary
  • Receptors, Transferrin
  • Receptors, Virus
  • Sequence Alignment
  • Virus Internalization
scroll to property group menus

Identity

PubMed Central ID

  • PMC3302512

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/jvi.06397-11

PubMed ID

  • 22278244
scroll to property group menus

Additional Document Info

start page

  • 4024

end page

  • 4028

volume

  • 86

issue

  • 7

©2019 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support