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The cyclophilin inhibitor SCY-635 suppresses viral replication and induces endogenous interferons in patients with chronic HCV genotype 1 infection

Academic Article
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Overview

authors

  • Hopkins, S.
  • DiMassimo, B.
  • Rusnak, P.
  • Heuman, D.
  • Lalezari, J.
  • Sluder, A.
  • Scorneaux, B.
  • Mosier, S.
  • Kowalczyk, P.
  • Ribeill, Y.
  • Baugh, J.
  • Gallay, Philippe

publication date

  • July 2012

journal

  • Journal of Hepatology  Journal

subject areas

  • Adult
  • Aged
  • Antiviral Agents
  • Carcinoma, Hepatocellular
  • Cell Line, Tumor
  • Cyclophilin A
  • Cyclophilins
  • Cyclosporins
  • Dose-Response Relationship, Drug
  • Female
  • Genotype
  • Hepacivirus
  • Hepatitis C, Chronic
  • Humans
  • Interferon-alpha
  • Interferon-beta
  • Interferon-gamma
  • Interleukins
  • Liver Neoplasms
  • Male
  • Middle Aged
  • Treatment Outcome
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Research

keywords

  • 2 ' 5 ' OAS-1
  • Chronic hepatitis C
  • Cyclophilin inhibitor
  • IL28B
  • Interferon alpha
  • Interferon lambda
  • SCY-635
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Identity

International Standard Serial Number (ISSN)

  • 0168-8278

Digital Object Identifier (DOI)

  • 10.1016/j.jhep.2012.02.024

PubMed ID

  • 22425702
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Additional Document Info

start page

  • 47

end page

  • 54

volume

  • 57

issue

  • 1

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