recent publications

• academic article

  • Goswami, D., Tuske, S., Pascal, B. D., Bauman, J. D., Patel, D., Arnold, E., Griffin, P. R. Differential isotopic enrichment to facilitate characterization of asymmetric multimeric proteins using hydrogen/deuterium exchange mass spectrometry Analytical Chemistry  2015 87:4015-4022  DOI:10.1021/acs.analchem.5b00372  PMID:25763479  PMCID:PMC4445842
  • Brown, N. E., Goswami, D., Branch, M. R., Ramineni, S., Ortlund, E. A., Griffin, P. R., Hepler, J. R. Integration of G protein a (Ga) signaling by the regulator of G protein signaling 14 (RGS14) Journal of Biological Chemistry  2015 290:9037-9049  DOI:10.1074/jbc.M114.634329  PMID:25666614  PMCID:PMC4423691
  • Goswami, D., Callaway, C., Pascal, B. D., Kumar, R., Edwards, D. P., Griffin, P. R. Influence of domain interactions on conformational mobility of the progesterone receptor detected by hydrogen/deuterium exchange mass spectrometry Structure  2014 22:961-973  DOI:10.1016/j.str.2014.04.013  PMID:24909783  PMCID:PMC4393884
  • Kirschke, E., Goswami, D., Southworth, D., Griffin, P. R., Agard, D. A. Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles Cell  2014 157:1685-1697  DOI:10.1016/j.cell.2014.04.038  PMID:24949977  PMCID:PMC4087167
  • Armstrong, E. H., Goswami, D., Griffin, P. R., Noy, N., Ortlund, E. A. Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta/delta (FABP5-PPAR beta/delta) signaling pathway Journal of Biological Chemistry  2014 289:14941-14954  DOI:10.1074/jbc.M113.514646  PMID:24692551  PMCID:PMC4031543
  • Qiang, G., Xue, S., Yang, J. J., Du, G., Pang, X., Li, X., Goswami, D., Griffin, P. R., Ortlund, E. A., Chan, C. B., Ye, K. Identification of a small molecular insulin receptor agonist with potent antidiabetes activity Diabetes  2014 63:1394-1409  DOI:10.2337/db13-0334  PMID:24651808  PMCID:PMC3964510
  • Marciano, D. P., Chang, M. R., Corzo, C. A., Goswami, D., Lam, V. Q., Pascal, B. D., Griffin, P. R. The therapeutic potential of nuclear receptor modulators for treatment of metabolic disorders: PPARγ, RORs, and Rev-erbs Cell Metabolism  2014 19:193-208  DOI:10.1016/j.cmet.2013.12.009  PMID:24440037
  • Zhang, Y., Goswami, D., Wang, D., Wang, T. S. A., Sen, S., Magliery, T. J., Griffin, P. R., Wang, F., Schultz, P. G. An antibody with a variable-region coiled-coil "knob" domain Angewandte Chemie-International Edition  2014 53:132-135  DOI:10.1002/anie.201307939  PMID:24254636  PMCID:PMC3926434
  • Landgraf, R. R., Goswami, D., Rajamohan, F., Harris, M. S., Calabrese, M. F., Hoth, L. R., Magyar, R., Pascal, B. D., Chalmers, M. J., Busby, S. A., Kurumbail, R. G., Griffin, P. R. Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry Structure  2013 21:1942-1953  DOI:10.1016/j.str.2013.08.023  PMID:24076403  PMCID:PMC3825792
  • Kumar, R., Moure, C. M., Khan, S. H., Callaway, C., Grimm, S. L., Goswami, D., Griffin, P. R., Edwards, D. P. Regulation of the structurally dynamic N-terminal domain of progesterone receptor by protein-induced folding Journal of Biological Chemistry  2013 288:30285-30299  DOI:10.1074/jbc.M113.491787  PMID:23995840  PMCID:PMC3798494
  • Goswami, D., Devarakonda, S., Chalmers, M. J., Pascal, B. D., Spiegelman, B. M., Griffin, P. R. Time window expansion for HDX analysis of an intrinsically disordered protein Journal of the American Society for Mass Spectrometry  2013 24:1584-1592  DOI:10.1007/s13361-013-0669-y  PMID:23884631  PMCID:PMC3773365
  • Harms, M. J., Eick, G. N., Goswami, D., Colucci, J. K., Griffin, P. R., Ortlund, E. A., Thornton, J. W. Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors Proceedings of the National Academy of Sciences of the United States of America  2013 110:11475-11480  DOI:10.1073/pnas.1303930110  PMID:23798447  PMCID:PMC3710831
  • Pascal, B. D., Willis, S., Lauer, J. L., Landgraf, R. R., West, G. M., Marciano, D., Novick, S., Goswami, D., Chalmers, M. J., Griffin, P. R. HDX workbench: software for the analysis of H/D exchange MS data Journal of the American Society for Mass Spectrometry  2012 23:1512-1521  DOI:10.1007/s13361-012-0419-6  PMID:22692830  PMCID:PMC3808162