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The BTB-ZF transcription factors

Academic Article
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Overview

related to degree

  • Siggs, Owen Marc, Ph.D. in Biology, Scripps Research , Joint graduate program with Oxford University 2007 - 2012

authors

  • Siggs, Owen Marc
  • Beutler, Bruce

publication date

  • September 2012

journal

  • Cell Cycle  Journal

abstract

  • The BTB-ZF (broad-complex, tramtrack and bric-?-brac--zinc finger) proteins are encoded by at least 49 genes in mouse and man and commonly serve as sequence-specific silencers of gene expression. This review will focus on the known physiological functions of mammalian BTB-ZF proteins, which include essential roles in the development of the immune system. We discuss their function in terminally differentiated lymphocytes and the progenitors that give rise to them, their action in hematopoietic malignancy and roles beyond the immune system.
  • The BTB-ZF (broad-complex, tramtrack and bric-à-brac--zinc finger) proteins are encoded by at least 49 genes in mouse and man and commonly serve as sequence-specific silencers of gene expression. This review will focus on the known physiological functions of mammalian BTB-ZF proteins, which include essential roles in the development of the immune system. We discuss their function in terminally differentiated lymphocytes and the progenitors that give rise to them, their action in hematopoietic malignancy and roles beyond the immune system.

subject areas

  • Animals
  • Hematologic Neoplasms
  • Humans
  • Immunity
  • Lymphopoiesis
  • Models, Biological
  • Transcription Factors
  • Zinc Fingers
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Research

keywords

  • BTB
  • hematopoiesis
  • lymphoma
  • lymphopoiesis
  • zinc finger
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Identity

PubMed Central ID

  • PMC3466544

International Standard Serial Number (ISSN)

  • 1538-4101

Digital Object Identifier (DOI)

  • 10.4161/cc.21277

PubMed ID

  • 22894929
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Additional Document Info

start page

  • 3358

end page

  • 3369

volume

  • 11

issue

  • 18

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