Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Chick embryo chorioallantoic membrane models to quantify angiogenesis induced by inflammatory and tumor cells or purified effector molecules

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Deryugina, Elena
  • Quigley, James

publication date

  • 2008

journal

  • Methods in Enzymology  Journal

abstract

  • Angiogenesis plays a critical role in many normal physiological processes as well as in tumor neovascularization associated with cancer progression. Among various animal model systems designed to study the mechanisms underlying angiogenesis, chick embryo models have been useful tools in analyzing the angiogenic potential of purified factors and intact cells. The chorioallantoic membrane (CAM), a specialized, highly vascularized tissue of the avian embryo, serves as an ideal indicator of the anti- or pro-angiogenic properties of test compounds. In this chapter, we describe a number basic chick embryo CAM models of angiogenesis. A special emphasis is on the model system employing three-dimensional (3D) collagen grafts planted on the CAM, referred herein as onplants. This collagen onplant model allows for unambiguous quantification of angiogenesis and also for in-depth analysis of the cellular and biochemical mechanisms by which specific cells of different origin or purified effector molecules induce or inhibit the angiogenic process.

subject areas

  • Animals
  • Chick Embryo
  • Chorioallantoic Membrane
  • Collagen
  • Disease Models, Animal
  • Humans
  • Inflammation
  • Neoplasms
  • Neovascularization, Pathologic
scroll to property group menus

Identity

PubMed Central ID

  • PMC2699944

International Standard Serial Number (ISSN)

  • 0076-6879 978-0-12-374313-8

Digital Object Identifier (DOI)

  • 10.1016/s0076-6879(08)02802-4

PubMed ID

  • 19007659
scroll to property group menus

Additional Document Info

start page

  • 21

end page

  • 41

volume

  • 444

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support