related to degree

• Chen, Ming, Ph.D. in Organic Chemistry, Scripps Research 2007 - 2012

authors

• Chen, Ming
• Roush, William

publication date

• 2012

journal

• Organic Letters  Journal

abstract

• Basiliskamide A is an antifungal polyketide natural product isolated by Andersen and co-workers from a Bacillus laterosporus isolate, PNG-276. A nine-step enantioselective synthesis of (-)-basiliskamide A is reported, starting from commercially available ?-hydroxy ester 7. The synthesis features a highly diastereoselective mismatched double asymmetric ?-stannylallylboration reaction of aldehyde 5 with the bifunctional allylborane reagent 4.
• Basiliskamide A is an antifungal polyketide natural product isolated by Andersen and co-workers from a Bacillus laterosporus isolate, PNG-276. A nine-step enantioselective synthesis of (-)-basiliskamide A is reported, starting from commercially available β-hydroxy ester 7. The synthesis features a highly diastereoselective mismatched double asymmetric δ-stannylallylboration reaction of aldehyde 5 with the bifunctional allylborane reagent 4.

subject areas

• Aldehydes
• Antifungal Agents
• Bacillus
• Biological Products
• Polyketides
• Stereoisomerism

PubMed Central ID

• PMC3306514

International Standard Serial Number (ISSN)

• 1523-7060

Digital Object Identifier (DOI)

• 10.1021/ol300282e

PubMed ID

• 22372693

start page

• 1556

end page

• 1559

volume

• 14

issue

• 6