recent publications
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academic article
- Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., Ahn, H. J., Ait-Mohamed, O., et al. Guidelines for the use and interpretation of assays for monitoring autophagy Autophagy 2012 8:445-544 DOI:10.4161/auto.19496 PMID:22966490 PMCID:PMC3404883
- Kitagawa, T., Iwazawa, T., Robbins, P. D., Lotze, M. T., Tahara, H. Advantages and limitations of particle-mediated transfection (gene gun) in cancer immuno-gene therapy using IL-10, IL-12 or B7-1 in murine tumor models Journal of Gene Medicine 2003 5:958-965 DOI:10.1002/jgm.441 PMID:14601133
- Nishioka, Y., Wen, H., Mitani, K., Robbins, P. D., Lotze, M. T., Sone, S., Tahara, H. Differential effects of il-12 on the generation of alloreactive ctl mediated by murine and human dendritic cells: A critical role for nitric oxide Journal of Leukocyte Biology 2003 73:621-629 DOI:10.1189/jlb.0402205 PMID:12714577
- Numasaki, M., Fukushi, J., Ono, M., Narula, S. K., Zavodny, P. J., Kudo, T., Robbins, P. D., Tahara, H., Lotze, M. T. Interleukin-17 promotes angiogenesis and tumor growth Blood 2003 101:2620-2627 DOI:10.1182/blood-2002-05-1461 PMID:12411307
- Hashimoto, W., Tanaka, F., Robbins, P. D., Taniguchi, M., Okamura, H., Lotze, M. T., Tahara, H. Natural killer, but not natural killer T, cells play a necessary role in the promotion of an innate antitumor response induced by IL-18 International Journal of Cancer 2003 103:508-513 DOI:10.1002/ijc.10844 PMID:12478667
- Gao, W. T., Kumar, S., Lotze, M. T., Hanning, C., Robbins, P. D., Gambotto, A. Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity Journal of Immunology 2003 170:107-113 PMID:12496389
- Tanaka, F., Hashimoto, W., Robbins, P. D., Lotze, M. T., Tahara, H. Therapeutic and specific antitumor immunity induced by co-administration of immature dendritic cells and adenoviral vector expressing biologically active IL-18 Gene Therapy 2002 9:1480-1486 DOI:10.1038/sj.gt.3301827 PMID:12378411
- Kang, W. K., Park, C., Yoon, H. L., Kim, W. S., Yoon, S. S., Lee, M. H., Park, K., Kim, K., Jeong, H. S., Kim, J. A., Nam, S. J., Yang, J. H., et al. Interleukin 12 gene therapy of cancer by peritumoral injection of transduced autologous fibroblasts: Outcome of a phase I study Human Gene Therapy 2001 12:671-684 DOI:10.1089/104303401300057388 PMID:11426466
- Iwazawa, T., Chau, G. Y., Mori, T., Dookeran, K. A., Rubin, J. T., Watkins, S., Robbins, P. D., Lotze, M. T., Tahara, H. Potent antitumor effects of intra-arterial injection of fibroblasts genetically engineered to express IL-12 in liver metastasis model of rat: No additional benefit of using retroviral producer cell Cancer Gene Therapy 2001 8:17-22 PMID:11219489
- Tanaka, F., Hashimoto, W., Okamura, H., Robbins, P. D., Lotze, M. T., Tahara, H. Rapid generation of potent and tumor-specific cytotoxic T lymphocytes by interleukin 18 using dendritic cells and natural killer cells Cancer Research 2000 60:4838-4844 PMID:10987295
- Hirao, M., Onai, N., Hiroishi, K., Watkins, S. C., Matsushima, K., Robbins, P. D., Lotze, M. T., Tahara, H. Cc chemokine receptor-7 on dendritic cells is induced after interaction with apoptotic tumor cells: Critical role in migration from the tumor site to draining lymph nodes Cancer Research 2000 60:2209-2217 PMID:10786686
- Okada, H., Pollack, I. F., Lotze, M. T., Lunsford, L. D., Kondziolka, D., Lieberman, F., Schiff, D., Attanucci, J., Edington, H., Chambers, W., Robbins, P., Baar, J., et al. Gene therapy of malignant gliomas: A phase I study of IL-4-HSV-TK gene-modified autologous tumor to elicit an immune response Human Gene Therapy 2000 11:637-653 PMID:10724042
- Lotze, M. T., Shurin, M., Esche, C., Tahara, H., Storkus, W., Kirkwood, J. M., Whiteside, T. L., Elder, E. M., Okada, H., Robbins, P. Interleukin-2: Developing additional cytokine gene therapies using fibroblasts or dendritic cells to enhance tumor immunity Cancer Journal from Scientific American 2000 6:S61-S66 PMID:10685662
- Nishioka, Y., Hirao, M., Robbins, P. D., Lotze, M. T., Tahara, H. Induction of systemic and therapeutic antitumor immunity using intratumoral injection of dendritic cells genetically modified to express interleukin 12 Cancer Research 1999 59:4035-4041 PMID:10463604
- Hashimoto, W., Osaki, T., Okamura, H., Robbins, P. D., Kurimoto, M., Nagata, S., Lotze, M. T., Tahara, H. Differential antitumor effects of administration of recombinant IL-18 or recombinant IL-12 are mediated primarily by Fas-Fas ligand- and perforin-induced tumor apoptosis, respectively Journal of Immunology 1999 163:583-589 PMID:10395644
- Esche, C., Gambotto, A., Satoh, Y., Gerein, V., Robbins, P. D., Watkins, S. C., Lotze, M. T., Shurin, M. R. CD154 inhibits tumor-induced apoptosis in dendritic cells and tumor growth European Journal of Immunology 1999 29:2148-2155 DOI:10.1002/(sici)1521-4141(199907)29:07<2148::aid-immu2148>3.0.co;2-f PMID:10427977
- Osaki, T., Hashimoto, W., Gambotto, A., Okamura, H., Robbins, P. D., Kurimoto, M., Lotze, M. T., Tahara, H. Potent antitumor effects mediated by local expression of the mature form of the interferon-gamma inducing factor, interleukin-18 (IL-18) Gene Therapy 1999 6:808-815 DOI:10.1038/sj.gt.3300908 PMID:10505105
- Gambotto, A., Tuting, T., McVey, D. L., Kovesdi, I., Tahara, H., Lotze, M. T., Robbins, P. D. Induction of antitumor immunity by direct intratumoral injection of a recombinant adenovirus vector expressing interleukin-12 Cancer Gene Therapy 1999 6:45-53 DOI:10.1038/sj.cgt.7700013 PMID:10078963
- Tuting, T., Gambotto, A., DeLeo, A., Lotze, M. T., Robbins, P. D., Storkus, W. J. Induction of tumor antigen-specific immunity using plasmid DNA immunization in mice Cancer Gene Therapy 1999 6:73-80 DOI:10.1038/sj.cgt.7700020 PMID:10078966
- Couderc, B., Zitvogel, L., Douin-Echinard, V., Djennane, L., Tahara, H., Favre, G., Lotze, M. T., Robbins, P. D. Enhancement of antitumor immunity by expression of CD70 (CD27 ligand) or CD154 (CD40 ligand) costimulatory molecules in tumor cells Cancer Gene Therapy 1998 5:163-175 PMID:9622100
- Osaki, T., Peron, J. M., Cai, Q. A., Okamura, H., Robbins, P. D., Kurimoto, M., Lotze, M. T., Tahara, H. Ifn-gamma-inducing factor il-18 administration mediates ifn-gamma- and il-12-independent antitumor effects Journal of Immunology 1998 160:1742-1749 PMID:9469432
- Douin-Echinard, V., Robbins, P. D., Lotze, M. T., Favre, G., Couderc, B. Enhancement of anti-tumor immunity by injection of fibroblasts genetically engineered to produce IL-12 and to express CD70 Advances in Experimental Medicine and Biology 1998 451:353-357 PMID:10026896
- Tuting, T., Gambotto, A., Baar, J., Davis, I. D., Storkus, W. J., Zavodny, P. J., Narula, S., Tahara, H., Robbins, P. D., Lotze, M. T. Interferon-alpha gene therapy for cancer: Retroviral transduction of fibroblasts and particle-mediated transfection of tumor cells are both effective strategies for gene delivery in murine tumor models Gene Therapy 1997 4:1053-1060 DOI:10.1038/sj.gt.3300509 PMID:9415311
- Kim, S. H., An, C. S., Tahara, H., Park, C., Lotze, M. T., Robbins, P. D., Kim, S. Retroviral-mediated IL-12 gene therapy for advanced murine tumors Experimental and Molecular Medicine 1997 29:53-58 DOI:10.1038/emm.1997.8
- Maeurer, M. J., Gollin, S. M., Martin, D., Swaney, W., Bryant, J., Castelli, C., Robbins, P., Parmiani, G., Storkus, W. J., Lotze, M. T. Tumor escape from immune recognition: lethal recurrent melanoma in a patient associated with downregulation of the peptide transporter protein TAP-1 and loss of expression of the immunodominant MART-1/Melan-A antigen Journal of Clinical Investigation 1996 98:1633-1641 DOI:10.1172/jci118958 PMID:8833913 PMCID:PMC507597
- Berman, R. M., Suzuki, T., Tahara, H., Robbins, P. D., Narula, S. K., Lotze, M. T. Systemic administration of cellular IL-10 induces an effective, specific, and long-lived immune response against established tumors in mice Journal of Immunology 1996 157:231-238 PMID:8683120
- Zitvogel, L., Robbins, P. D., Storkus, W. J., Clarke, M. R., Maeurer, M. J., Campbell, R. L., Davis, C. G., Tahara, H., Schreiber, R. D., Lotze, M. T. Interleukin-12 and B7.1 co-stimulation cooperate in the induction of effective antitumor immunity and therapy of established tumors European Journal of Immunology 1996 26:1335-1341 DOI:10.1002/eji.1830260624 PMID:8647214
- Qin, L. H., Chavin, K. D., Ding, Y. Z., Tahara, H., Favaro, J. P., Woodward, J. E., Suzuki, T., Robbins, P. D., Lotze, M. T., Bromberg, J. S. Retrovirus-mediated transfer of viral IL-10 gene prolongs murine cardiac allograft survival Journal of Immunology 1996 156:2316-2323 PMID:8690923
- Lotze, M. T., Zitvogel, L., Campbell, R., Robbins, P. D., Elder, E., Haluszczak, C., Martin, D., Whiteside, T. L., Storkus, W. J., Tahara, H. Cytokine gene therapy of cancer using interleukin-12: murine and clinical trials Annals of the New York Academy of Sciences 1996 795:440-454 DOI:10.1111/j.1749-6632.1996.tb52715.x PMID:8958977
- Zitvogel, L., Couderc, B., Mayordomo, J. I., Robbins, P. D., Lotze, M. T., Storkus, W. J. IL-12-engineered dendritic cells serve as effective tumor vaccine adjuvants in vivo Annals of the New York Academy of Sciences 1996 795:284-293 DOI:10.1111/j.1749-6632.1996.tb52678.x PMID:8958940
- Tahara, H., Zitvogel, L., Storkus, W. J., Robbins, P. D., Lotze, M. T. Murine models of cancer cytokine gene therapy using interleukin-12 Annals of the New York Academy of Sciences 1996 795:275-283 DOI:10.1111/j.1749-6632.1996.tb52677.x PMID:8958939
- Zitvogel, L., Tahara, H., Robbins, P. D., Storkus, W. J., Clarke, M. R., Nalesnik, M. A., Lotze, M. T. Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblasts Journal of Immunology 1995 155:1393-1403 PMID:7636204
- Suzuki, T., Tahara, H., Narula, S., Moore, K. W., Robbins, P. D., Lotze, M. T. Viral interleukin-10 (IL-10), the human herpes-virus-4 cellular IL-10 homolog, induces local anergy to allogeneic and syngeneic tumors Journal of Experimental Medicine 1995 182:477-486 DOI:10.1084/jem.182.2.477 PMID:7629507
- Tahara, H., Zitvogel, L., Storkus, W. J., Zeh, H. J., McKinney, T. G., Schreiber, R. D., Gubler, U., Robbins, P. D., Lotze, M. T. Effective eradication of established murine tumors with IL-12 gene-therapy using a polycistronic retroviral vector Journal of Immunology 1995 154:6466-6474 PMID:7759882
- Pappo, I., Tahara, H., Robbins, P. D., Gately, M. K., Wolf, S. F., Barnea, A., Lotze, M. T. Administration of systemic or local interleukin-2 enhances the antitumor effects of interleukin-12 gene-therapy Journal of Surgical Research 1995 58:218-226 DOI:10.1006/jsre.1995.1034 PMID:7861776
- Zitvogel, L., Tahara, H., Cai, Q., Storkus, W. J., Muller, G., Wolf, S. F., Gately, M., Robbins, P. D., Lotze, M. T. Construction and characterization of retroviral vectors expressing biologically active human interleukin-12 Human Gene Therapy 1994 5:1493-1506 DOI:10.1089/hum.1994.5.12-1493 PMID:7711142
- Tahara, H., Zeh, H. J., Storkus, W. J., Pappo, I., Watkins, S. C., Gubler, U., Wolf, S. F., Robbins, P. D., Lotze, M. T. Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo Cancer Research 1994 54:182-189 PMID:7903204
- Robbins, P. D., Tahara, H., Mueller, G., Hung, G., Bahnson, A., Zitvogel, L., Galealauri, J., Ohashi, T., Patrene, K., Boggs, S. S., Evans, C. H., Barranger, J. A., et al. Retroviral vectors for use in human gene-therapy for cancer Gaucher disease, and arthritis Annals of the New York Academy of Sciences 1994 716:72-89 DOI:10.1111/j.1749-6632.1994.tb21704.x PMID:7912915
- Tahara, H., Mueller, G. M., Ricordi, C., Robbins, P. D., Lotze, M. T. Islet cell transplantation facilitated by gene-transfer Transplantation Proceedings 1992 24:2975-2976 PMID:1466019