recent publications
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academic article
- Mercer, A. C., Gaj, T., Sirk, S. J., Lamb, B. M., Barbas III, C. F. Regulation of endogenous human gene expression by ligand-inducible TALE transcription factors ACS Synthetic Biology 2014 3:723-730 DOI:10.1021/sb400114p PMID:24251925 PMCID:PMC4097969
- Gaj, T., Liu, J., Anderson, K. E., Sirk, S. J., Barbas III, C. F. Protein delivery using Cys2-His2 zinc-finger domains ACS Chemical Biology 2014 9:1662-1667 DOI:10.1021/cb500282g PMID:24936957 PMCID:PMC4519095
- Sirk, S. J., Gaj, T., Jonsson, A., Mercer, A. C., Barbas III, C. F. Expanding the zinc-finger recombinase repertoire: directed evolution and mutational analysis of serine recombinase specificity determinants Nucleic Acids Research 2014 42:4755-4766 DOI:10.1093/nar/gkt1389 PMID:24452803 PMCID:PMC3985619
- Liu, J., Gaj, T., Patterson, J. T., Sirk, S. J., Barbas III, C. F. Cell-penetrating peptide-mediated delivery of TALEN proteins via bioconjugation for genome engineering PLoS One 2014 9:e85755 DOI:10.1371/journal.pone.0085755 PMID:24465685 PMCID:PMC3896395
- Gaj, T., Sirk, S. J., Barbas III, C. F. Expanding the scope of site-specific recombinases for genetic and metabolic engineering Biotechnology and Bioengineering 2014 111:1-15 DOI:10.1002/bit.25096 PMID:23982993 PMCID:PMC4097888
- Gavrilyuk, J., Ban, H., Uehara, H., Sirk, S. J., Saye-Francisco, K., Cuevas, A., Zablowsky, E., Oza, A., Seaman, M. S., Burton, D. R., Barbas, C. F. Antibody conjugation approach enhances breadth and potency of neutralization of anti-HIV-1 antibodies and CD4-IgG Journal of Virology 2013 87:4985-4993 DOI:10.1128/jvi.03146-12 PMID:23427154 PMCID:PMC3624287
- Gaj, T., Mercer, A. C., Sirk, S. J., Smith, H. L., Barbas III, C. F. A comprehensive approach to zinc-finger recombinase customization enables genomic targeting in human cells Nucleic Acids Research 2013 41:3937-3946 DOI:10.1093/nar/gkt071 PMID:23393187 PMCID:PMC3616721
- Gaj, T., Guo, J., Kato, Y., Sirk, S. J., Barbas III, C. F. Targeted gene knockout by direct delivery of zinc-finger nuclease proteins Nature Methods 2012 9:805-7 DOI:10.1038/nmeth.2030 PMID:22751204 PMCID:PMC3424280