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Dopaminergic neurons encode a distributed, asymmetric representation of temperature in drosophila

Academic Article
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Overview

authors

  • Tomchik, Seth

publication date

  • January 2013

journal

  • Journal of Neuroscience  Journal

abstract

  • Dopaminergic circuits modulate a wide variety of innate and learned behaviors in animals, including olfactory associative learning, arousal, and temperature-preference behavior. It is not known whether distinct or overlapping sets of dopaminergic neurons modulate these behaviors. Here, I have functionally characterized the dopaminergic circuits innervating the Drosophila mushroom body with in vivo calcium imaging and conditional silencing of genetically defined subsets of neurons. Distinct subsets of PPL1 dopaminergic neurons innervating the vertical lobes of the mushroom body responded to decreases in temperature, but not increases, with rapidly adapting bursts of activity. PAM neurons innervating the horizontal lobes did not respond to temperature shifts. Ablation of the antennae and maxillary palps reduced, but did not eliminate, the responses. Genetic silencing of dopaminergic neurons innervating the vertical mushroom body lobes substantially reduced behavioral cold avoidance, but silencing smaller subsets of these neurons had no effect. These data demonstrate that overlapping dopaminergic circuits encode a broadly distributed, asymmetric representation of temperature that overlays regions implicated previously in learning, memory, and forgetting. Thus, diverse behaviors engage overlapping sets of dopaminergic neurons that encode multimodal stimuli and innervate a single anatomical target, the mushroom body.

subject areas

  • Animals
  • Behavior, Animal
  • Dopaminergic Neurons
  • Drosophila
  • Mushroom Bodies
  • Nerve Net
  • Smell
  • Temperature
  • Thermosensing
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Identity

International Standard Serial Number (ISSN)

  • 0270-6474

Digital Object Identifier (DOI)

  • 10.1523/jneurosci.3933-12.2013

PubMed ID

  • 23365252
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Additional Document Info

start page

  • 2166

end page

  • 2176A

volume

  • 33

issue

  • 5

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