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A direct interaction of axonin-1 with NgCAM-related cell adhesion molecule (NrCAM) results in guidance, but not growth of commissural axons

Academic Article
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Overview

authors

  • Fitzli, D.
  • Stoeckli, E. T.
  • Kunz, S.
  • Siribour, K.
  • Rader, Christoph
  • Kunz, B.
  • Kozlov, S. V.
  • Buchstaller, A.
  • Lane, R. P.
  • Suter, D. M.
  • Dreyer, W. J.
  • Sonderegger, P.

publication date

  • May 2000

journal

  • Journal of Cell Biology  Journal

abstract

  • An interaction of growth cone axonin-1 with the floor-plate NgCAM-related cell adhesion molecule (NrCAM) was shown to play a crucial role in commissural axon guidance across the midline of the spinal cord. We now provide evidence that axonin-1 mediates a guidance signal without promoting axon elongation. In an in vitro assay, commissural axons grew preferentially on stripes coated with a mixture of NrCAM and NgCAM. This preference was abolished in the presence of anti-axonin-1 antibodies without a decrease in neurite length. Consistent with these findings, commissural axons in vivo only fail to extend along the longitudinal axis when both NrCAM and NgCAM interactions, but not when axonin-1 and NrCAM or axonin-1 and NgCAM interactions, are perturbed. Thus, we conclude that axonin-1 is involved in guidance of commissural axons without promoting their growth.

subject areas

  • Animals
  • Axons
  • Binding Sites
  • Cell Adhesion
  • Cell Adhesion Molecules
  • Cell Adhesion Molecules, Neuron-Glia
  • Cell Adhesion Molecules, Neuronal
  • Cells, Cultured
  • Chick Embryo
  • Contactin 2
  • Embryonic Induction
  • Growth Cones
  • Multigene Family
  • Neural Pathways
  • Protein Binding
  • Recombinant Proteins
  • Spinal Cord
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Research

keywords

  • axon guidance
  • growth cone
  • neuronal cell adhesion molecules immunoglobulin superfamily
  • signal transduction
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Identity

International Standard Serial Number (ISSN)

  • 0021-9525

Digital Object Identifier (DOI)

  • 10.1083/jcb.149.4.951

PubMed ID

  • 10811834
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Additional Document Info

start page

  • 951

end page

  • 968

volume

  • 149

issue

  • 4

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