recent publications
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academic article
- Medema, M. H., Kottmann, R., Yilmaz, P., Cummings, M., Biggins, J. B., Blin, K., de Bruijn, I., Chooi, Y. H., Claesen, J., Coates, R. C., Cruz-Morales, P., Duddela, S., et al. Minimum information about a biosynthetic gene cluster Nature Chemical Biology 2015 11:625-631 PMID:26284661
- Thompson, P. R., Boehr, D. D., Berghuis, A. M., Wright, G. D. Mechanism of aminoglycoside antibiotic kinase aph(3 ')-iiia: Role of the nucleotide positioning loop Biochemistry 2002 41:7001-7007 DOI:10.1021/bi0256680 PMID:12033933
- Boehr, D. D., Thompson, P. R., Wright, G. D. Molecular mechanism of aminoglycoside antibiotic kinase aph(3 ')-iiia - roles of conserved active site residues Journal of Biological Chemistry 2001 276:23929-23936 DOI:10.1074/jbc.M100540200 PMID:11279088
- Sucheck, S. J., Wong, A. L., Koeller, K. M., Boehr, D. D., Draker, K., Sears, P., Wright, G. D., Wong, C. H. Design of bifunctional antibiotics that target bacterial rRNA and inhibit resistance-causing enzymes Journal of the American Chemical Society 2000 122:5230-5231 DOI:10.1021/ja000575w
- DeLaBarre, B., Thompson, P. R., Wright, G. D., Berghuis, A. M. Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases Nature Structural Biology 2000 7:238-244 PMID:10700284
- Thompson, P. R., Schwartzenhauer, J., Hughes, D. W., Berghuis, A. M., Wright, G. D. The cooh terminus of aminoglycoside phosphotransferase (3 ')-iiia is critical for antibiotic recognition and resistance Journal of Biological Chemistry 1999 274:30697-30706 DOI:10.1074/jbc.274.43.30697 PMID:10521458
- Daigle, D. M., McKay, G. A., Thompson, P. R., Wright, G. D. Aminoglycoside antibiotic phosphotransferases are also serine protein kinases Chemistry & Biology 1999 6:11-18 DOI:10.1016/s1074-5521(99)80016-7 PMID:9889150
- Thompson, P. R., Hughes, D. W., Cianciotto, N. P., Wright, G. D. Spectinomycin kinase from legionella pneumophila - characterization of substrate specificity and identification of catalytically important residues Journal of Biological Chemistry 1998 273:14788-14795 DOI:10.1074/jbc.273.24.14788 PMID:9614079
- Hon, W. C., McKay, G. A., Thompson, P. R., Sweet, R. M., Yang, D. S. C., Wright, G. D., Berghuis, A. M. Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases Cell 1997 89:887-895 DOI:10.1016/s0092-8674(00)80274-3 PMID:9200607
- Thompson, P. R., Hughes, D. W., Wright, G. D. Mechanism of aminoglycoside 3'-phosphotransferase type iiia: His188 is not a phosphate-accepting residue Chemistry & Biology 1996 3:747-755 DOI:10.1016/s1074-5521(96)90251-3 PMID:8939691
- Thompson, P. R., Hughes, D. W., Wright, G. D. Regiospecificity of aminoglycoside phosphotransferase from enterococci and staphylococci (aph(3')-iiia) Biochemistry 1996 35:8686-8695 DOI:10.1021/bi960389w PMID:8679631
- McKay, G. A., Thompson, P. R., Wright, G. D. Broad-spectrum aminoglycoside phosphotransferase type-iii from enterococcus - overexpression, purification, and substrate-specificity Biochemistry 1994 33:6936-6944 DOI:10.1021/bi00188a024 PMID:8204627