recent publications

• academic article

  • Medema, M. H., Kottmann, R., Yilmaz, P., Cummings, M., Biggins, J. B., Blin, K., de Bruijn, I., Chooi, Y. H., Claesen, J., Coates, R. C., Cruz-Morales, P., Duddela, S., et al. Minimum information about a biosynthetic gene cluster Nature Chemical Biology  2015 11:625-631  PMID:26284661
  • Thompson, P. R., Boehr, D. D., Berghuis, A. M., Wright, G. D. Mechanism of aminoglycoside antibiotic kinase aph(3 ')-iiia: Role of the nucleotide positioning loop Biochemistry  2002 41:7001-7007  DOI:10.1021/bi0256680  PMID:12033933
  • Boehr, D. D., Thompson, P. R., Wright, G. D. Molecular mechanism of aminoglycoside antibiotic kinase aph(3 ')-iiia - roles of conserved active site residues Journal of Biological Chemistry  2001 276:23929-23936  DOI:10.1074/jbc.M100540200  PMID:11279088
  • DeLaBarre, B., Thompson, P. R., Wright, G. D., Berghuis, A. M. Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases Nature Structural Biology  2000 7:238-244  PMID:10700284
  • Sucheck, S. J., Wong, A. L., Koeller, K. M., Boehr, D. D., Draker, K., Sears, P., Wright, G. D., Wong, C. H. Design of bifunctional antibiotics that target bacterial rRNA and inhibit resistance-causing enzymes Journal of the American Chemical Society  2000 122:5230-5231  DOI:10.1021/ja000575w
  • Daigle, D. M., McKay, G. A., Thompson, P. R., Wright, G. D. Aminoglycoside antibiotic phosphotransferases are also serine protein kinases Chemistry & Biology  1999 6:11-18  DOI:10.1016/s1074-5521(99)80016-7  PMID:9889150
  • Thompson, P. R., Schwartzenhauer, J., Hughes, D. W., Berghuis, A. M., Wright, G. D. The cooh terminus of aminoglycoside phosphotransferase (3 ')-iiia is critical for antibiotic recognition and resistance Journal of Biological Chemistry  1999 274:30697-30706  DOI:10.1074/jbc.274.43.30697  PMID:10521458
  • Thompson, P. R., Hughes, D. W., Cianciotto, N. P., Wright, G. D. Spectinomycin kinase from legionella pneumophila - characterization of substrate specificity and identification of catalytically important residues Journal of Biological Chemistry  1998 273:14788-14795  DOI:10.1074/jbc.273.24.14788  PMID:9614079
  • Hon, W. C., McKay, G. A., Thompson, P. R., Sweet, R. M., Yang, D. S. C., Wright, G. D., Berghuis, A. M. Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases Cell  1997 89:887-895  DOI:10.1016/s0092-8674(00)80274-3  PMID:9200607
  • Thompson, P. R., Hughes, D. W., Wright, G. D. Mechanism of aminoglycoside 3'-phosphotransferase type iiia: His188 is not a phosphate-accepting residue Chemistry & Biology  1996 3:747-755  DOI:10.1016/s1074-5521(96)90251-3  PMID:8939691
  • Thompson, P. R., Hughes, D. W., Wright, G. D. Regiospecificity of aminoglycoside phosphotransferase from enterococci and staphylococci (aph(3')-iiia) Biochemistry  1996 35:8686-8695  DOI:10.1021/bi960389w  PMID:8679631
  • McKay, G. A., Thompson, P. R., Wright, G. D. Broad-spectrum aminoglycoside phosphotransferase type-iii from enterococcus - overexpression, purification, and substrate-specificity Biochemistry  1994 33:6936-6944  DOI:10.1021/bi00188a024  PMID:8204627