recent publications
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academic article
- Miles, L. A., Lighvani, S., Baik, N., Parmer, C. M., Khaldoyanidi, S., Mueller, B. M., Parmer, R. J. New insights into the role of Plg-RKT in macrophage recruitment International Review of Cell and Molecular Biology 2014 309:259-302 DOI:10.1016/b978-0-12-800255-1.00005-3 PMID:24529725
- Schaffner, F., Yokota, N., Carneiro-Lobo, T., Kitano, M., Schaffer, M., Anderson, G. M., Mueller, B. M., Esmon, C. T., Ruf, W. Endothelial protein C receptor function in murine and human breast cancer development PLoS One 2013 8:e61071 DOI:10.1371/journal.pone.0061071 PMID:23593394 PMCID:PMC3621887
- Schaffner, F., Versteeg, H. H., Schillert, A., Yokota, N., Petersen, L. C., Mueller, B. M., Ruf, W. Cooperation of tissue factor cytoplasmic domain and par2 signaling in breast cancer development Blood 2010 116:6106-6113 DOI:10.1182/blood-2010-06-289314 PMID:20861457 PMCID:PMC3031395
- Versteeg, H. H., Schaffner, F., Kerver, M., Ellies, L. G., Andrade-Gordon, P., Mueller, B. M., Ruf, W. Protease-activated receptor (par) 2, but not par1, signaling promotes the development of mammary adenocarcinoma in polyoma middle t mice Cancer Research 2008 68:7219-7227 DOI:10.1158/0008-5472.can-08-0419 PMID:18757438 PMCID:PMC2596617
- Versteeg, H. H., Schaffner, F., Kerver, M., Petersen, H. H., Ahamed, J., Felding-Habermann, B., Takada, Y., Mueller, B. M., Ruf, W. Inhibition of tissue factor signaling suppresses tumor growth Blood 2008 111:190-199 DOI:10.1182/blood-2007-07-101048 PMID:17901245 PMCID:PMC2200804
- Uusitalo-Jarvinen, H., Kurokawa, T., Mueller, B. M., Andrade-Gordon, P., Friedlander, M., Ruf, W. Role of protease activated receptor 1 and 2 signaling in hypoxia-induced angiogenesis Arteriosclerosis, Thrombosis, and Vascular Biology 2007 27:1456-1462 DOI:10.1161/atvbaha.107.142539 PMID:17363687
- Ahamed, J., Versteeg, H. H., Kerver, M., Chen, V. M., Mueller, B. M., Hogg, P. J., Ruf, W. Disulfide isomerization switches tissue factor from coagulation to cell signaling Proceedings of the National Academy of Sciences of the United States of America 2006 103:13932-13937 DOI:10.1073/pnas.0606411103 PMID:16959886 PMCID:PMC1599891
- Guo, F., Das, S., Mueller, B. M., Barbas, C. F., Lerner, R. A., Sinha, S. C. Breaking the one antibody-one target axiom Proceedings of the National Academy of Sciences of the United States of America 2006 103:11009-11014 DOI:10.1073/pnas.0603822103 PMID:16822849 PMCID:PMC1488731
- Ruf, W., Mueller, B. M. Thrombin generation and the pathogenesis of cancer Seminars in Thrombosis and Hemostasis 2006 32:61-68 DOI:10.1055/s-2006-939555 PMID:16673267
- Jessani, N., Niessen, S., Mueller, B. M., Cravatt, B. F. Breast cancer cell lines grown in vivo: What goes in isn't always the same as what comes out Cell Cycle 2005 4:253-255 PMID:15655359
- Jessani, N., Humphrey, M., McDonald, W. H., Niessen, S., Masuda, K., Gangadharan, B., Yates, J. R., 3rd, Mueller, B. M., Cravatt, B. F. Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo Proceedings of the National Academy of Sciences of the United States of America 2004 101:13756-13761 DOI:10.1073/pnas.0404727101 PMID:15356343 PMCID:PMC518829
- Shi, X. L., Gangadharan, B., Brass, L. F., Ruf, W., Mueller, B. M. Protease-activated receptors (par1 and par2) contribute to tumor cell motility and metastasis Molecular Cancer Research 2004 2:395-402 PMID:15280447
- Belting, M., Dorrell, M. I., Sandgren, S., Aguilar, E., Ahamed, J., Dorfleutner, A., Carmeliet, P., Mueller, B. M., Friedlander, M., Ruf, W. Regulation of angiogenesis by tissue factor cytoplasmic domain signaling Nature Medicine 2004 10:502-509 DOI:10.1038/nm1037 PMID:15098027
- Riewald, M., Petrovan, R. J., Donner, A., Mueller, B. M., Ruf, W. Activation of endothelial cell protease activated receptor 1 by the protein c pathway Science 2002 296:1880-1882 DOI:10.1126/science.1071699 PMID:12052963
- Felding-Habermann, B., O'Toole, T. E., Smith, J. W., Fransvea, E., Ruggeri, Z. M., Ginsberg, M. H., Hughes, P. E., Pampori, N., Shattil, S. J., Saven, A., Mueller, B. M. Integrin activation controls metastasis in human breast cancer Proceedings of the National Academy of Sciences of the United States of America 2001 98:1853-1858 DOI:10.1073/pnas.98.4.1853 PMID:11172040 PMCID:PMC29346
- Ott, I., Miyagi, Y., Miyazaki, K., Heeb, M. J., Mueller, B. M., Rao, L. V. M., Ruf, W. Reversible regulation of tissue factor-induced coagulation by glycosyl phosphatidylinositol-anchored tissue factor pathway inhibitor Arteriosclerosis, Thrombosis, and Vascular Biology 2000 20:874-882 PMID:10712416
- Ruf, W., Fischer, E. G., Huang, H. Y., Miyagi, Y., Ott, I., Riewald, M., Mueller, B. M. Diverse functions of protease receptor tissue factor in inflammation and metastasis Immunologic Research 2000 21:289-292 DOI:10.1385/ir:21:2-3:289 PMID:10852129
- Fischer, E. G., Riewald, M., Huang, H. Y., Miyagi, Y., Kubota, Y., Mueller, B. M., Ruf, W. Tumor cell adhesion and migration supported by interaction of a receptor-protease complex with its inhibitor Journal of Clinical Investigation 1999 104:1213-1221 DOI:10.1172/jci7750 PMID:10545520
- Ruf, W., Mueller, B. M. Tissue factor signaling Thrombosis and Haemostasis 1999 82:175-182 PMID:10605702
- Dolman, C. S., Mueller, B. M., Lode, H. N., Xiang, R., Gillies, S. D., Reisfeld, R. A. Suppression of human prostate carcinoma metastases in severe combined immunodeficient mice by interleukin 2 immunocytokine therapy Clinical Cancer Research 1998 4:2551-2557 PMID:9796990
- Mueller, B. M., Ruf, W. Requirement for binding of catalytically active factor viia in tissue factor-dependent experimental metastasis Journal of Clinical Investigation 1998 101:1372-1378 DOI:10.1172/jci930 PMID:9525979
- Ott, I., Fischer, E. G., Miyagi, Y., Mueller, B. M., Ruf, W. A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein 280 Journal of Cell Biology 1998 140:1241-1253 DOI:10.1083/jcb.140.5.1241 PMID:9490735
- Wong, N. C., Mueller, B. M., Barbas, C. F., Ruminski, P., Quaranta, V., Lin, E. C. K., Smith, J. W. Alpha(v) integrins mediate adhesion and migration of breast carcinoma cell lines Clinical & Experimental Metastasis 1998 16:50-61 PMID:9502077
- Sivam, G. P., Martin, P. J., Reisfeld, R. A., Mueller, B. M. Therapeutic efficacy of a doxorubicin immunoconjugate in a preclinical model of spontaneous metastatic human-melanoma Cancer Research 1995 55:2352-2356 PMID:7757986
- Fischer, E. G., Ruf, W., Mueller, B. M. Tissue factor-initiated thrombin generation activates the signaling thrombin receptor on malignant-melanoma cells Cancer Research 1995 55:1629-1632 PMID:7712465
- Montgomery, A. M. P., Mueller, B. M., Reisfeld, R. A., Taylor, S. M., Declerck, Y. A. Effect of tissue inhibitor of the matrix metalloproteinases-2 expression on the growth and spontaneous metastasis of a human-melanoma cell-line Cancer Research 1994 54:5467-5473 PMID:7923181
- Sabzevari, H., Gillies, S. D., Mueller, B. M., Pancook, J. D., Reisfeld, R. A. A recombinant antibody interleukin-2 fusion protein suppresses growth of hepatic human neuroblastoma metastases in severe combined immunodeficiency mice Proceedings of the National Academy of Sciences of the United States of America 1994 91:9626-9630 DOI:10.1073/pnas.91.20.9626 PMID:7937818
- Naramura, M., Gillies, S. D., Mendelsohn, J., Reisfeld, R. A., Mueller, B. M. Mechanisms of cellular cytotoxicity mediated by a recombinant antibody il2 fusion protein against human-melanoma cells Immunology Letters 1993 39:91-99 DOI:10.1016/0165-2478(93)90169-3 PMID:8144194
- Naramura, M., Gillies, S. D., Mendelsohn, J., Reisfeld, R. A., Mueller, B. M. Therapeutic potential of chimeric and murine anti-(epidermal growth-factor receptor) antibodies in a metastasis model for human-melanoma Cancer Immunology Immunotherapy 1993 37:343-349 DOI:10.1007/bf01518458 PMID:8402738
- Montgomery, A. M. P., Declerck, Y. A., Langley, K. E., Reisfeld, R. A., Mueller, B. M. Melanoma-mediated dissolution of extracellular-matrix - contribution of urokinase-dependent and metalloproteinase-dependent proteolytic pathways Cancer Research 1993 53:693-700 PMID:8425205
- Mueller, B. M., Reisfeld, R. A., Edgington, T. S., Ruf, W. Expression of tissue factor by melanoma-cells promotes efficient hematogenous metastasis Proceedings of the National Academy of Sciences of the United States of America 1992 89:11832-11836 DOI:10.1073/pnas.89.24.11832 PMID:1465406
- Schrappe, M., Bumol, T. F., Apelgren, L. D., Briggs, S. L., Koppel, G. A., Markowitz, D. D., Mueller, B. M., Reisfeld, R. A. Long-term growth suppression of human glioma xenografts by chemoimmunoconjugates of 4-desacetylvinblastine-3-carboxyhydrazide and monoclonal-antibody 9.2.27 Cancer Research 1992 52:3838-3844 PMID:1617657
- Feldinghabermann, B., Mueller, B. M., Romerdahl, C. A., Cheresh, D. A. Involvement of integrin alpha V gene expression in human melanoma tumorigenicity Journal of Clinical Investigation 1992 89:2018-2022 DOI:10.1172/jci115811 PMID:1376331 PMCID:PMC295910
- Haenseler, E., Esswein, A., Vitols, K. S., Montejano, Y., Mueller, B. M., Reisfeld, R. A., Huennekens, F. M. Activation of methotrexate-alpha-alanine by carboxypeptidase-A monoclonal-antibody conjugate Biochemistry 1992 31:891-897 DOI:10.1021/bi00118a035 PMID:1731945
- Sanders, L. C., Feldinghabermann, B., Mueller, B. M., Cheresh, D. A. Role of alpha V integrins and vitronectin in human melanoma cell growth Cold Spring Harbor Symposia on Quantitative Biology 1992 57:233-240 PMID:1285050
- Mueller, B. M., Reisfeld, R. A. Potential of the scid mouse as a host for human tumors Cancer and Metastasis Reviews 1991 10:193-200 DOI:10.1007/bf00050791 PMID:1764764
- Reisfeld, R. A., Mueller, B. M., Schrappe, M., Wargalla, U., Yang, H. M., Wrasidlo, W. Antibody-drug conjugates for cancer therapy: promises and problems Immunology and Allergy Clinics of North America 1991 11:341-358
- Mueller, B. M., Romerdahl, C. A., Trent, J. M., Reisfeld, R. A. Suppression of spontaneous melanoma metastasis in scid mice with an antibody to the epidermal growth-factor receptor Cancer Research 1991 51:2193-2198 PMID:2009538
- Dorai, H., Mueller, B. M., Reisfeld, R. A., Gillies, S. D. Aglycosylated chimeric mouse human iggl antibody retains some effector function Hybridoma 1991 10:211-217 DOI:10.1089/hyb.1991.10.211 PMID:1874515
- Barker, E., Mueller, B. M., Handgretinger, R., Herter, M., Yu, A. L., Reisfeld, R. A. Effect of a chimeric antiganglioside gd2 antibody on cell-mediated lysis of human neuroblastoma-cells Cancer Research 1991 51:144-149 PMID:1988079
- Mueller, B. M., Reisfeld, R. A., Silveira, M. H., Duncan, J. D., Wrasidlo, W. A. Preclinical therapy of human-melanoma with morpholino-doxorubicin conjugated to a monoclonal-antibody directed against an integrin on melanoma-cells Antibody Immunoconjugates and Radiopharmaceuticals 1991 4:99-106
- Mueller, B. M., Wrasidlo, W. A., Reisfeld, R. A. Antibody conjugates with morpholinodoxorubicin and acid-cleavable linkers Bioconjugate Chemistry 1990 1:325-330 DOI:10.1021/bc00005a005 PMID:1711377
- Mueller, B. M., Reisfeld, R. A., Gillies, S. D. Serum half-life and tumor-localization of a chimeric antibody deleted of the ch2 domain and directed against the disialoganglioside-gd2 Proceedings of the National Academy of Sciences of the United States of America 1990 87:5702-5705 DOI:10.1073/pnas.87.15.5702 PMID:2198570
- Mueller, B. M., Romerdahl, C. A., Gillies, S. D., Reisfeld, R. A. Enhancement of antibody-dependent cytotoxicity with a chimeric anti-gd2 antibody Journal of Immunology 1990 144:1382-1386 PMID:2303711
- Hank, J. A., Robinson, R. R., Surfus, J., Mueller, B. M., Reisfeld, R. A., Cheung, N. K., Sondel, P. M. Augmentation of antibody dependent cell mediated cytotoxicity following in vivo therapy with recombinant interleukin 2 Cancer Research 1990 50:5234-5239 PMID:2386933
- Mueller, B. M., Wrasidlo, W. A., Reisfeld, R. A. Determination of the number of epsilon-amino groups available for conjugation of effector molecules to monoclonal-antibodies Hybridoma 1988 7:453-456 DOI:10.1089/hyb.1988.7.453 PMID:3143663