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Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice

Academic Article
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Overview

related to degree

  • Su, Andrew, Ph.D. in Chemistry, Scripps Research 1998 - 2002

authors

  • Su, Andrew
  • Guidotti, Luca
  • Pezacki, J. P.
  • Chisari, Francis
  • Schultz, Peter

publication date

  • August 2002

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • Understanding the gene-expression patterns during liver regeneration may help to reveal how regenerative processes are initiated and controlled as well as shed new light onto processes that lead to liver disease. Using high-density oligonucleotide arrays, we have examined the gene-expression program in the livers of mice after partial hepatectomy. A time course was constructed for gene expression between 0 and 4 h after partial hepatectomy, corresponding to the priming phase of liver regeneration. The genomic program for liver regeneration involves transcription-factor generation, stress and inflammatory responses, cytoskeletal and extracellular matrix modification, and regulation of cell-cycle entry. The genome-wide changes that are observed provide a detailed and comprehensive map of the initial priming stage of liver regeneration.

subject areas

  • Animals
  • Base Sequence
  • DNA Primers
  • Enzymes
  • Gene Expression Regulation
  • Hepatectomy
  • Liver
  • Liver Regeneration
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Oligonucleotide Array Sequence Analysis
  • Proteins
  • Reverse Transcriptase Polymerase Chain Reaction
  • Transcription Factors
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Identity

PubMed Central ID

  • PMC123230

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.122359899

PubMed ID

  • 12177410
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Additional Document Info

start page

  • 11181

end page

  • 11186

volume

  • 99

issue

  • 17

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