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T-cell receptor beta-chain binding to enterotoxin superantigens

Academic Article
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Overview

authors

  • Irwin, M. J.
  • Hudson, K. R.
  • Ames, K. T.
  • Fraser, J. D.
  • Gascoigne, Nicholas

publication date

  • February 1993

journal

  • Immunological Reviews  Journal

abstract

  • The last few years have seen an enormous jump in our knowledge and understanding of T-cell activation by superantigens. Clearly, a great number of infectious and parasitic organisms utilize superantigens as part of a strategy to evade the immune response of their host. The ability to modulate superantigen effects will give us new means to fight infections, and the knowledge of T-cell activation that we have gained from study of superantigens will, in turn, allow us to modulate the immune system in new ways.

subject areas

  • Animals
  • Antigens, Bacterial
  • Binding Sites
  • Enterotoxins
  • HLA-DR Antigens
  • Histocompatibility Antigens Class II
  • Humans
  • Mutation
  • Receptors, Antigen, T-Cell, alpha-beta
  • Staphylococcus aureus
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Identity

International Standard Serial Number (ISSN)

  • 0105-2896

Digital Object Identifier (DOI)

  • 10.1111/j.1600-065X.1993.tb01530.x

PubMed ID

  • 8486394
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Additional Document Info

start page

  • 61

end page

  • 78

volume

  • 131

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