Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Systemic kappa-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Walker, B. M.
  • Zorrilla, Eric
  • Koob, George

publication date

  • January 2011

journal

  • Addiction Biology  Journal

abstract

  • Altered dynorphin opioid peptide systems contribute to increased ethanol self-administration during withdrawal following chronic alcohol exposure. We previously identified that the κ-opioid receptor antagonist nor-binaltorphimine (nor-BNI) selectively reduced ethanol self-administration in dependent animals. The purpose of this study was twofold: (1) determine whether peripherally administered nor-BNI could reduce dependence-induced ethanol self-administration and (2) confirm the selective κ-opioid effects of nor-BNI by administering it 24 hours prior to ethanol self-administration sessions occurring during acute withdrawal. Nor-BNI decreased ethanol self-administration in ethanol-dependent animals, with no effect in nondependent animals. Thus, the κ-opioid/dynorphin system is a viable pharmacotherapeutic target for the treatment of alcoholism.

subject areas

  • Administration, Inhalation
  • Alcohol Deterrents
  • Alcoholism
  • Animals
  • Dose-Response Relationship, Drug
  • Dynorphins
  • Ethanol
  • Injections, Subcutaneous
  • Male
  • Naltrexone
  • Narcotic Antagonists
  • Premedication
  • Rats
  • Rats, Wistar
  • Receptors, Opioid, kappa
  • Self Administration
  • Substance Withdrawal Syndrome
scroll to property group menus

Research

keywords

  • Alcohol
  • dependence
  • dynorphin
  • nor-binaltorphimine (nor-BNI)
  • self-administration
  • withdrawal
scroll to property group menus

Identity

PubMed Central ID

  • PMC2988980

International Standard Serial Number (ISSN)

  • 1355-6215

Digital Object Identifier (DOI)

  • 10.1111/j.1369-1600.2010.00226.x

PubMed ID

  • 20579007
scroll to property group menus

Additional Document Info

start page

  • 116

end page

  • 119

volume

  • 16

issue

  • 1

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support