recent publications
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academic article
- Yano, J. K., Wester, M. R., Schoch, G. A., Griffin, K. J., Stout, C. D., Johnson, E. F. The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05 Å resolution Journal of Biological Chemistry 2004 279:38091-38094 DOI:10.1074/jbc.C400293200 PMID:15258162
- Schoch, G. A., Yano, J. K., Wester, M. R., Griffin, K. J., Stout, C. D., Johnson, E. F. Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site Journal of Biological Chemistry 2004 279:9497-9503 DOI:10.1074/jbc.M312516200 PMID:14676196
- Wester, M. R., Yano, J. K., Schoch, G. A., Yang, C., Griffin, K. J., Stout, C. D., Johnson, E. F. The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0 Å resolution Journal of Biological Chemistry 2004 279:35630-35637 DOI:10.1074/jbc.M405427200 PMID:15181000
- Scott, E. E., He, Y. A., Wester, M. R., White, M. A., Chin, C. C., Halpert, J. R., Johnson, E. F., Stout, C. D. An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution Proceedings of the National Academy of Sciences of the United States of America 2003 100:13196-13201 DOI:10.1073/pnas.2133986100 PMID:14563924 PMCID:PMC263748
- Wester, M. R., Johnson, E. F., Marques-Soares, C., Dansette, P. M., Mansuy, D., Stout, C. D. Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 A resolution: evidence for multiple substrate binding modes Biochemistry 2003 42:6370-6379 DOI:10.1021/bi0273922 PMID:12767218
- Wester, M. R., Johnson, E. F., Marques-Soares, C., Dijols, S., Dansette, P. M., Mansuy, D., Stout, C. D. Structure of mammalian cytochrome P450 2C5 complexed with diclofenac at 2.1 A resolution: evidence for an induced fit model of substrate binding Biochemistry 2003 42:9335-9345 DOI:10.1021/bi0345561 PMID:12899620
- Marques-Soares, C., Dijols, S., Macherey, A. C., Wester, M. R., Johnson, E. F., Dansette, P. M., Mansuy, D. Sulfaphenazole derivatives as tools for comparing cytochrome P450 2C5 and human cytochromes P450 2Cs: identification of a new high affinity substrate common to those enzymes Biochemistry 2003 42:6363-6369 DOI:10.1021/bi027391+ PMID:12767217
- Wester, M. R., Stout, C. D., Johnson, E. F. Purification and crystallization of N-terminally truncated forms of microsomal cytochrome P450 2C5 Methods in Enzymology 2002 357:73-79 DOI:10.1016/S0076-6879(02)57667-9 PMID:12424899
- Johnson, E. F., Wester, M. R., Stout, C. D. The structure of microsomal cytochrome P450 2C5: a steroid and drug metabolizing enzyme Endocrine Research 2002 28:435-441 DOI:10.1081/erc-120016820 PMID:12530646
- Spatzenegger, M., Wang, Q. M., He, Y. Q., Wester, M. R., Johnson, E. F., Halpert, J. R. Amino acid residues critical for differential inhibition of CYP2B4, CYP2B5, and CYP2B1 by phenylimidazoles Molecular Pharmacology 2001 59:475-484 PMID:11179442
- Tsao, C. C., Wester, M. R., Ghanayem, B., Coulter, S. J., Chanas, B., Johnson, E. F., Goldstein, J. A. Identification of human CYP2C19 residues that confer S-mephenytoin 4'-hydroxylation activity to CYP2C9 Biochemistry 2001 40:1937-1944 DOI:10.1021/bi001678u PMID:11329260
- Savas, U., Wester, M. R., Griffin, K. J., Johnson, E. F. Rabbit pregnane X receptor is activated by rifampicin Drug Metabolism and Disposition 2000 28:529-537 PMID:10772631
- Wester, M. R., Lasker, J. M., Johnson, E. F., Raucy, J. L. CYP2C19 participates in tolbutamide hydroxylation by human liver microsomes Drug Metabolism and Disposition 2000 28:354-359 PMID:10681382