recent publications

• academic article

  • Schoch, G. A., Yano, J. K., Wester, M. R., Griffin, K. J., Stout, C. D., Johnson, E. F. Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site Journal of Biological Chemistry  2004 279:9497-9503  DOI:10.1074/jbc.M312516200  PMID:14676196
  • Wester, M. R., Yano, J. K., Schoch, G. A., Yang, C., Griffin, K. J., Stout, C. D., Johnson, E. F. The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0 Å resolution Journal of Biological Chemistry  2004 279:35630-35637  DOI:10.1074/jbc.M405427200  PMID:15181000
  • Yano, J. K., Wester, M. R., Schoch, G. A., Griffin, K. J., Stout, C. D., Johnson, E. F. The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05 Å resolution Journal of Biological Chemistry  2004 279:38091-38094  DOI:10.1074/jbc.C400293200  PMID:15258162
  • Scott, E. E., He, Y. A., Wester, M. R., White, M. A., Chin, C. C., Halpert, J. R., Johnson, E. F., Stout, C. D. An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution Proceedings of the National Academy of Sciences of the United States of America  2003 100:13196-13201  DOI:10.1073/pnas.2133986100  PMID:14563924  PMCID:PMC263748
  • Wester, M. R., Johnson, E. F., Marques-Soares, C., Dansette, P. M., Mansuy, D., Stout, C. D. Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 A resolution: evidence for multiple substrate binding modes Biochemistry  2003 42:6370-6379  DOI:10.1021/bi0273922  PMID:12767218
  • Wester, M. R., Johnson, E. F., Marques-Soares, C., Dijols, S., Dansette, P. M., Mansuy, D., Stout, C. D. Structure of mammalian cytochrome P450 2C5 complexed with diclofenac at 2.1 A resolution: evidence for an induced fit model of substrate binding Biochemistry  2003 42:9335-9345  DOI:10.1021/bi0345561  PMID:12899620
  • Marques-Soares, C., Dijols, S., Macherey, A. C., Wester, M. R., Johnson, E. F., Dansette, P. M., Mansuy, D. Sulfaphenazole derivatives as tools for comparing cytochrome P450 2C5 and human cytochromes P450 2Cs: identification of a new high affinity substrate common to those enzymes Biochemistry  2003 42:6363-6369  DOI:10.1021/bi027391+  PMID:12767217
  • Wester, M. R., Stout, C. D., Johnson, E. F. Purification and crystallization of N-terminally truncated forms of microsomal cytochrome P450 2C5 Methods in Enzymology  2002 357:73-79  DOI:10.1016/S0076-6879(02)57667-9  PMID:12424899
  • Johnson, E. F., Wester, M. R., Stout, C. D. The structure of microsomal cytochrome P450 2C5: a steroid and drug metabolizing enzyme Endocrine Research  2002 28:435-441  DOI:10.1081/erc-120016820  PMID:12530646
  • Spatzenegger, M., Wang, Q. M., He, Y. Q., Wester, M. R., Johnson, E. F., Halpert, J. R. Amino acid residues critical for differential inhibition of CYP2B4, CYP2B5, and CYP2B1 by phenylimidazoles Molecular Pharmacology  2001 59:475-484  PMID:11179442
  • Tsao, C. C., Wester, M. R., Ghanayem, B., Coulter, S. J., Chanas, B., Johnson, E. F., Goldstein, J. A. Identification of human CYP2C19 residues that confer S-mephenytoin 4'-hydroxylation activity to CYP2C9 Biochemistry  2001 40:1937-1944  DOI:10.1021/bi001678u  PMID:11329260
  • Wester, M. R., Lasker, J. M., Johnson, E. F., Raucy, J. L. CYP2C19 participates in tolbutamide hydroxylation by human liver microsomes Drug Metabolism and Disposition  2000 28:354-359  PMID:10681382
  • Savas, U., Wester, M. R., Griffin, K. J., Johnson, E. F. Rabbit pregnane X receptor is activated by rifampicin Drug Metabolism and Disposition  2000 28:529-537  PMID:10772631