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Il-21 is required to control chronic viral infection

Academic Article
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Overview

authors

  • Elsaesser, H.
  • Sauer, Karsten
  • Brooks, D. G.

publication date

  • 2009

journal

  • Science  Journal

abstract

  • CD4+ and CD8+ T cell functions are rapidly aborted during chronic infection, preventing viral clearance. CD4+ T cell help is required throughout chronic infection so as to sustain CD8+ T cell responses; however, the necessary factor(s) provided by CD4+ T cells are currently unknown. Using a mouse model of chronic viral infection, we demonstrated that interleukin-21 (IL-21) is an essential component of CD4+ T cell help. In the absence of IL-21 signaling, despite elevated CD4+ T cell responses, CD8+ T cell responses are severely impaired. CD8+ T cells directly require IL-21 to avoid deletion, maintain immunity, and resolve persistent infection. Thus, IL-21 specifically sustains CD8+ T cell effector activity and provides a mechanism of CD4+ T cell help during chronic viral infection.

subject areas

  • Animals
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Chronic Disease
  • Interleukins
  • Lymphocyte Activation
  • Lymphocyte Depletion
  • Lymphocytic Choriomeningitis
  • Lymphocytic choriomeningitis virus
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Signal Transduction
  • Virus Diseases
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Identity

PubMed Central ID

  • PMC2830017

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1174182

PubMed ID

  • 19423777
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Additional Document Info

start page

  • 1569

end page

  • 1572

volume

  • 324

issue

  • 5934

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