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Stimuli associated with a single cocaine experience elicit longlasting cocaine-seeking

Academic Article
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Overview

authors

  • Ciccocioppo, R.
  • Martin-Fardon, Remi
  • Weiss, Friedbert

publication date

  • May 2004

journal

  • Nature Neuroscience  Journal

abstract

  • Epidemiological data suggest that cocaine dependence emerges rapidly, and most cocaine addicts meet criteria for dependence within 1-3 years after onset of drug use. Here we show that in rats, environmental stimuli associated with a single cocaine self-administration experience elicit strong cocaine-seeking that persists for up to one year. In contrast, conditioned stimuli that were associated with a highly palatable non-drug reinforcer elicited modest behavioral responses that extinguished within 3 months.

subject areas

  • Acoustic Stimulation
  • Analysis of Variance
  • Animals
  • Behavior, Addictive
  • Behavior, Animal
  • Cocaine
  • Cocaine-Related Disorders
  • Conditioning, Operant
  • Extinction, Psychological
  • Rats
  • Reinforcement (Psychology)
  • Time Factors
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Identity

International Standard Serial Number (ISSN)

  • 1097-6256

Digital Object Identifier (DOI)

  • 10.1038/nn1219

PubMed ID

  • 15048121
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Additional Document Info

start page

  • 495

end page

  • 496

volume

  • 7

issue

  • 5

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