recent publications
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academic article
- Dreyton, C. J., Knuckley, B., Jones, J. E., Lewallen, D. M., Thompson, P. R. Mechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanism Biochemistry 2014 53:4426-4433 DOI:10.1021/bi500554b PMID:24989433 PMCID:PMC4100781
- Foyn, H., Jones, J. E., Lewallen, D., Narawane, R., Varhaug, J. E., Thompson, P. R., Arnesen, T. Design, synthesis, and kinetic characterization of protein N-terminal acetyltransferase inhibitors ACS Chemical Biology 2013 8:1121-1127 DOI:10.1021/cb400136s PMID:23557624
- Jones, J. E., Slack, J. L., Fang, P. F., Zhang, X. S., Subramanian, V., Causey, C. P., Coonrod, S. A., Guo, M., Thompson, P. R. Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors ACS Chemical Biology 2012 7:160-165 DOI:10.1021/cb200258q PMID:22004374 PMCID:PMC3262960
- Obianyo, O., Causey, C. P., Jones, J. E., Thompson, P. R. Activity-based protein profiling of protein arginine methyltransferase 1 ACS Chemical Biology 2011 6:1127-1135 DOI:10.1021/cb2001473 PMID:21838253 PMCID:PMC3199286
- Chumanevich, A. A., Causey, C. P., Knuckley, B. A., Jones, J. E., Poudyal, D., Chumanevich, A. P., Davis, T., Matesic, L. E., Thompson, P. R., Hofseth, L. J. Suppression of colitis in mice by cl-amidine: A novel peptidylarginine deiminase inhibitor American Journal of Physiology-Gastrointestinal and Liver Physiology 2011 300:G929-G938 DOI:10.1152/ajpgi.00435.2010 PMID:21415415 PMCID:PMC3119113
- Causey, C. P., Jones, J. E., Slack, J. L., Kamei, D., Jones, L. E., Subramanian, V., Knuckley, B., Ebrahimi, P., Chumanevich, A. A., Luo, Y., Hashimoto, H., Sato, M., et al. The development of n-alpha-(2-carboxyl)benzoyl-n(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-f-amidine) and n-alpha-(2-carboxyl)benzoyl-n(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-cl-amidine) as second generation protein arginine deiminase (pad) inhibitors Journal of Medicinal Chemistry 2011 54:6919-6935 DOI:10.1021/jm2008985 PMID:21882827 PMCID:PMC3196593
- Jones, J. E., Dreyton, C. J., Flick, H., Causey, C. P., Thompson, P. R. Mechanistic studies of agmatine deiminase from multiple bacterial species Biochemistry 2010 49:9413-9423 DOI:10.1021/bi101405y PMID:20939536 PMCID:PMC2964429
- Knuckley, B., Causey, C. P., Jones, J. E., Bhatia, M., Dreyton, C. J., Osborne, T. C., Takahara, H., Thompson, P. R. Substrate specificity and kinetic studies of pads 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3 Biochemistry 2010 49:4852-4863 DOI:10.1021/bi100363t PMID:20469888 PMCID:PMC2884139
- Obianyo, O., Causey, C. P., Osborne, T. C., Jones, J. E., Lee, Y. H., Stallcup, M. R., Thompson, P. R. A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: Design, synthesis, and in vitro and in vivo evaluation ChemBioChem 2010 11:1219-1223 DOI:10.1002/cbic.201000209 PMID:20480486 PMCID:PMC3060404
- Jones, J. E., Causey, C. P., Lovelace, L., Knuckley, B., Flick, H., Lebioda, L., Thompson, P. R. Characterization and inactivation of an agmatine deiminase from helicobacter pylori Bioorganic Chemistry 2010 38:62-73 DOI:10.1016/j.bioorg.2009.11.004 PMID:20036411 PMCID:PMC2823940
- Knuckley, B., Jones, J. E., Bachovchin, D. A., Slack, J., Causey, C. P., Brown, S. J., Rosen, H., Cravatt, B. F., Thompson, P. R. A fluopol-ABPP HTS assay to identify PAD inhibitors Chemical Communications 2010 46:7175-7177 DOI:10.1039/c0cc02634d PMID:20740228 PMCID:PMC2943038
- Jones, J. E., Causey, C. P., Knuckley, B., Slack-Noyes, J. L., Thompson, P. R. Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential Current Opinion in Drug Discovery & Development 2009 12:616-627 PMID:19736621 PMCID:PMC3771078
- Pollard, K. M., Jones, J. E., Tan, E. M., Theofilopoulos, A. N., Dixon, F. J., Rubin, R. L. Polynucleotide specificities of murine monoclonal anti-DNA antibodies Clinical Immunology and Immunopathology 1986 40:197-208 DOI:10.1016/0090-1229(86)90022-x PMID:3487402
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report
- Dreyton, C. J., Jones, J. E., Knuckley, B. A., Subramanian, V., Anderson, E. D., Brown, S. J., Fernandez-Vega, V., Eberhart, C., Spicer, T., Zuhl, A. M., Ferguson, J., Speers, A. E., et al. Optimization and characterization of a pan protein arginine deiminase (PAD) inhibitor Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:23833800