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Viral clearance without destruction of infected cells during acute HBV infection

Academic Article
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Overview

authors

  • Guidotti, Luca
  • Rochford, R.
  • Chung, J.
  • Shapiro, M.
  • Purcell, R.
  • Chisari, Francis

publication date

  • April 1999

journal

  • Science  Journal

abstract

  • Viral clearance during hepatitis B virus (HBV) infection has been thought to reflect the destruction of infected hepatocytes by CD8(+) T lymphocytes. However, in this study, HBV DNA was shown to largely disappear from the liver and the blood of acutely infected chimpanzees long before the peak of T cell infiltration and most of the liver disease. These results demonstrate that noncytopathic antiviral mechanisms contribute to viral clearance during acute viral hepatitis by purging HBV replicative intermediates from the cytoplasm and covalently closed circular viral DNA from the nucleus of infected cells.

subject areas

  • Acute Disease
  • Animals
  • Cytotoxicity, Immunologic
  • DNA, Circular
  • DNA, Viral
  • Hepatitis B
  • Hepatitis B Antibodies
  • Hepatitis B Core Antigens
  • Hepatitis B virus
  • Killer Cells, Natural
  • Liver
  • Mice
  • Mice, Transgenic
  • Pan troglodytes
  • T-Lymphocytes
  • Time Factors
  • Virus Replication
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.284.5415.825

PubMed ID

  • 10221919
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Additional Document Info

start page

  • 825

end page

  • 829

volume

  • 284

issue

  • 5415

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