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T cell homeostasis

Academic Article
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Overview

authors

  • Sprent, Jonathan
  • Cho, J. H.
  • Boyman, O.
  • Surh, Charles

publication date

  • June 2008

journal

  • Immunology and Cell Biology  Journal

abstract

  • The pool of mature T cells comprises a heterogeneous mixture of naive and memory CD4(+) and CD8(+) cells. These cells are long lived at a population level but differ markedly in their relative rates of turnover and survival. Here, we review how contact with exogenous stimuli, notably self MHC ligands and various gamma(c) cytokines, plays a decisive role in controlling normal T cell homeostasis.

subject areas

  • Aging
  • Animals
  • Cell Proliferation
  • Cytokines
  • Homeostasis
  • Humans
  • T-Lymphocytes
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Research

keywords

  • MHC ligands
  • T cells
  • cytokines
  • thymus
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Identity

International Standard Serial Number (ISSN)

  • 0818-9641

Digital Object Identifier (DOI)

  • 10.1038/icb.2008.12

PubMed ID

  • 18362947
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Additional Document Info

start page

  • 312

end page

  • 319

volume

  • 86

issue

  • 4

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