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Differential effects of morphine- and cocaine-induced nnos immunoreactivity in the dentate gyrus of hippocampus of mice lacking mu-opioid receptors

Academic Article
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Overview

authors

  • Yoo, J. H.
  • Cho, J. H.
  • Lee, S. Y.
  • Lee, S.
  • Loh, H. H.
  • Ho, I. K.
  • Jang, Choon-Gon

publication date

  • March 2006

journal

  • Neuroscience Letters  Journal

abstract

  • This study investigated the expression of nNOS after repeated morphine or cocaine administration in order to determine if nNOS (neuronal nitric oxide synthase) is involved in the morphine- or cocaine-induced behavioral sensitization in mu-opioid receptor knockout (MOR(-/-)) mice. Higher numbers of nNOS-positive cells were observed in the dentate gyrus of the hippocampus (DG) of the wild-type (MOR(+/+)) mice repeatedly treated with either morphine or cocaine than in the saline treated MOR(+/+) mice (morphine, +122%; cocaine, +82%). Moreover, the MOR(-/-) mice also showed significantly higher morphine- or cocaine-induced nNOS expression levels in the DG than in the saline treated MOR(+/+) mice (morphine, +234%; cocaine, +54%). The MOR(-/-) mice showed a significantly higher morphine-induced nNOS expression level (+103%) or a lower cocaine-induced nNOS expression level (+38%) in the DG than in the morphine- or cocaine-treated MOR(+/+) mice. These results suggest that morphine and cocaine sensitization is differentially regulated by the mu-opioid receptors in MOR(-/-) mice via the nNOS systems in the DG.

subject areas

  • Animals
  • Cocaine
  • Dentate Gyrus
  • Dopamine Uptake Inhibitors
  • Immunohistochemistry
  • Mice
  • Mice, Knockout
  • Morphine
  • Narcotics
  • Nitric Oxide Synthase Type I
  • Receptors, Opioid, mu
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Research

keywords

  • cocaine
  • immunohistochemistry
  • knockout mice
  • morphine
  • mu-opioid receptors
  • nNOS
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Identity

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/j.neulet.2005.10.089

PubMed ID

  • 16300892
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Additional Document Info

start page

  • 98

end page

  • 102

volume

  • 395

issue

  • 2

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