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Ala-1 - murine alloantigen of activated lymphocytes .II. T and B effector cells express Ala-1

Academic Article
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Overview

authors

  • Feeney, Ann
  • Hammerling, U.

publication date

  • 1977

journal

  • Journal of Immunology  Journal

abstract

  • Ala-1 (activated lymphocyte antigen-1) is a murine alloantigen expressed only on activated peripheral T and B lymphocytes. The presence or absence of Ala-1 on specific functional lymphocyte subsets was determined by treating the relevant cell population with anti-Ala-1 and complement, and assaying for residual functional activity. By this method, Ala-1 was shown to be on in vivo primed killer T cells cytotoxic for allogeneic tumor cells. It was also found on helper T cells generated in vivo to sheep red blood cells, and on IgM and IgG plaque-forming cells (PFC) to sheep red blood cells. In contrast, splenic precursors of helper cells and of IgM PFC to sheep red blood cells were completely resistant to treatment with anti-Ala-1 and complement. These findings indicate that effector cells can be distinguished from their nonactivated precursors by their expression of Ala-1.

subject areas

  • Animals
  • Antibody-Producing Cells
  • Antilymphocyte Serum
  • B-Lymphocytes
  • Cell Differentiation
  • Cell Division
  • Cell Membrane
  • Complement System Proteins
  • Cytotoxicity Tests, Immunologic
  • Epitopes
  • Erythrocytes
  • Immunoglobulin G
  • Immunoglobulin M
  • In Vitro Techniques
  • Isoantibodies
  • Isoantigens
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C3H
  • Spleen
  • T-Lymphocytes
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Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 66297
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Additional Document Info

start page

  • 1488

end page

  • 1494

volume

  • 118

issue

  • 4

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