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Catalysis of a stereospecific bimolecular amide synthesis by an antibody

Academic Article
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Overview

authors

  • Benkovic, S. J.
  • Napper, A. D.
  • Lerner, Richard

publication date

  • August 1988

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • We report a nonhydrolytic bimolecular aminolysis reaction catalyzed by an antibody. The stereospecific formation of an amide from racemic lactone plus an aromatic amine is described by a random equilibrium bireactant kinetic sequence. The observed turnover rate may be approximated from the measured difference between the binding of reactants and the transition state analog.

subject areas

  • Amides
  • Antibodies
  • Catalysis
  • Chemical Phenomena
  • Chemistry
  • Chromatography, High Pressure Liquid
  • Lactones
  • Phenylenediamines
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Identity

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.85.15.5355

PubMed ID

  • 3399496
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Additional Document Info

start page

  • 5355

end page

  • 5358

volume

  • 85

issue

  • 15

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