recent publications

• academic article

  • Williams, R. S., Moncalian, G., Williams, J. S., Yamada, Y., Limbo, O., Shin, D. S., Groocock, L. M., Cahill, D., Hitomi, C., Guenther, G., Moiani, D., Carney, J. P., et al. Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair Cell  2008 135:97-109  DOI:10.1016/j.cell.2008.08.017  PMID:18854158  PMCID:PMC2681233
  • de Jager, M., Trujillo, K. M., Sung, P., Hopfner, K. P., Carney, J. P., Tainer, J. A., Connelly, J. C., Leach, D. R. F., Kanaar, R., Wyman, C. Differential arrangements of conserved building blocks among homologs of the rad50/mre11 DNA repair protein complex Journal of Molecular Biology  2004 339:937-949  DOI:10.1016/j.jmb.2004.04.014  PMID:15165861
  • Arthur, L. M., Gustausson, K., Hopfner, K. P., Carson, C. T., Stracker, T. H., Karcher, A., Felton, D., Weitzman, M. D., Tainer, J., Carney, J. P. Structural and functional analysis of mre11-3 Nucleic Acids Research  2004 32:1886-1893  DOI:10.1093/nar/gkh343  PMID:15047855  PMCID:PMC390353
  • Hopfner, K. P., Craig, L., Moncalian, G., Zinkel, R. A., Usui, T., Owen, B. A. L., Karcher, A., Henderson, B., Bodmer, J. L., McMurray, C. T., Carney, J. P., Petrini, J. H. J., et al. The rad50 zinc-hook is a structure joining mre11 complexes in DNA recombination and repair Nature  2002 418:562-566  DOI:10.1038/nature00922  PMID:12152085
  • Hopfner, K. P., Karcher, A., Craig, L., Woo, T. T., Carney, J. P., Tainer, J. A. Structural biochemistry and interaction architecture of the DNA double-strand break repair mre11 nuclease and rad50-atpase Cell  2001 105:473-485  DOI:10.1016/s0092-8674(01)00335-x  PMID:11371344
  • Hopfner, K. P., Karcher, A., Shin, D., Fairley, C., Tainer, J. A., Carney, J. P. Mre11 and rad50 from pyrococcus furiosus: Cloning and biochemical characterization reveal an evolutionarily conserved multiprotein machine Journal of Bacteriology  2000 182:6036-6041  DOI:10.1128/jb.182.21.6036-6041.2000  PMID:11029422
  • Hopfner, K. P., Karcher, A., Shin, D. S., Craig, L., Arthur, L. M., Carney, J. P., Tainer, J. A. Structural biology of rad50 atpase: Atp-driven conformational control in DNA double-strand break repair and the abc-atpase superfamily Cell  2000 101:789-800  DOI:10.1016/s0092-8674(00)80890-9  PMID:10892749
  • Carney, J. P., Maser, R. S., Olivares, H., Davis, E. M., Le Beau, M., Yates, J. R., Hays, L., Morgan, W. F., Petrini, J. H. J. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response Cell  1998 93:477-486  DOI:10.1016/s0092-8674(00)81175-7  PMID:9590181