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Site-directed elisa identifies a highly antigenic region of the simian immunodeficiency virus transmembrane glycoprotein

Academic Article
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Overview

authors

  • Johnson, P. R.
  • Parks, D. E.
  • Norrby, E.
  • Lerner, Richard
  • Purcell, R. H.
  • Chanock, R. M.

publication date

  • June 1988

journal

  • AIDS Research and Human Retroviruses  Journal

abstract

  • The transmembrane glycoprotein (gp32) of the simian immunodeficiency virus (SIV) contains a highly antigenic region that includes amino acid residues 606-628. A synthetic peptide representing this region was highly immunoreactive with sera from SIV-infected primates in a site-directed enzyme-linked immunosorbent assay (ELISA). This reactivity extended across four primate species from three genera and identified infection with at least two distinct isolates of SIV. This site-directed ELISA represents a simple, accessible method with broad specificity for screening large numbers of primates for antibodies against SIV.

subject areas

  • Amino Acid Sequence
  • Animals
  • Antigens, Viral
  • Cercopithecus aethiops
  • Enzyme-Linked Immunosorbent Assay
  • Glycoproteins
  • Macaca mulatta
  • Monkey Diseases
  • Retroviridae
  • Viral Envelope Proteins
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Identity

International Standard Serial Number (ISSN)

  • 0889-2229

Digital Object Identifier (DOI)

  • 10.1089/aid.1988.4.159

PubMed ID

  • 3395516
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Additional Document Info

start page

  • 159

end page

  • 164

volume

  • 4

issue

  • 3

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