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Endocannabinoids restrict hippocampal long-term potentiation via cb1

Academic Article
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Overview

authors

  • Slanina, K. A.
  • Roberto, Marisa
  • Schweitzer, Paul

publication date

  • 2005

journal

  • Neuropharmacology  Journal

abstract

  • Cannabinoid ligands alter cognition and prevent long-term potentiation (LTP) of synaptic transmission, but the influence of endogenously formed cannabinoids (eCBs) on hippocampal LTP remains ambiguous. In the accompanying study, we showed that eCB levels regulated by cyclooxygenase-2 (COX-2) tonically decrease basal excitatory transmission. Here, we investigated the influence of eCBs on LTP in CA1 hippocampus. LTP elicited by moderate stimulations (20 or 50 pulses) was facilitated in slices treated with a CB1 antagonist, whereas LTP elicited with robust stimulations (100 or 200 pulses) was unchanged by CB1 blockade. LTP elicited with theta-burst stimulations also was facilitated with CB1 blockade, revealing a tonic inhibitory influence of eCBs on LTP induction. Conversely, inhibition of COX-2 prevented LTP elicited with theta burst stimulations. Inhibition of COX-1 or other routes of eCB degradation did not affect LTP. We conclude that COX-2 regulates the formation of CB1 ligands that negatively regulate LTP.

subject areas

  • Animals
  • Cannabinoid Receptor Modulators
  • Cyclooxygenase 2
  • Cyclooxygenase 2 Inhibitors
  • Cyclooxygenase Inhibitors
  • Electric Stimulation
  • Electrophysiology
  • Endocannabinoids
  • Excitatory Postsynaptic Potentials
  • Hippocampus
  • In Vitro Techniques
  • Long-Term Potentiation
  • Male
  • Membrane Potentials
  • Patch-Clamp Techniques
  • Prostaglandin-Endoperoxide Synthases
  • Rats
  • Rats, Sprague-Dawley
  • Receptor, Cannabinoid, CB1
  • Theta Rhythm
  • Thiazines
  • Thiazoles
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Research

keywords

  • cannabinoid
  • cyclooxygenase
  • meloxicam
  • slice
  • synaptic potentiation
  • theta-burst
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Identity

International Standard Serial Number (ISSN)

  • 0028-3908

Digital Object Identifier (DOI)

  • 10.1016/j.neurpharm.2005.04.021

PubMed ID

  • 15950248
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Additional Document Info

start page

  • 660

end page

  • 668

volume

  • 49

issue

  • 5

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