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The discovery of 3-(n-alkyl)aminopropylphosphonic acids as potent s1p receptor agonists

Academic Article
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Overview

authors

  • Hale, J. J.
  • Doherty, G.
  • Toth, L.
  • Li, Z.
  • Mills, S. G.
  • Hajdu, R.
  • Keohane, C. A.
  • Rosenbach, M.
  • Milligan, J.
  • Shei, G. J.
  • Chrebet, G.
  • Bergstrom, J.
  • Card, D.
  • Rosen, Hugh
  • Mandala, S.

publication date

  • July 2004

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

abstract

  • 3-(N-Alkyl)aminopropylphosphonic acids are potent agonists of four of the five known sphingosine-1-phosphate (S1P) receptor subtypes.

subject areas

  • Animals
  • CHO Cells
  • Cricetinae
  • Humans
  • Inhibitory Concentration 50
  • Ligands
  • Organophosphonates
  • Organophosphorus Compounds
  • Phosphorus Radioisotopes
  • Receptors, G-Protein-Coupled
  • Receptors, Lysosphingolipid
  • Structure-Activity Relationship
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2004.04.069

PubMed ID

  • 15177460
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Additional Document Info

start page

  • 3495

end page

  • 3499

volume

  • 14

issue

  • 13

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