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Spine-type-specific recruitment of newly synthesized AMPA receptors with learning

Academic Article
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Overview

authors

  • Matsuo, N.
  • Reijmers, L.
  • Mayford, Mark

publication date

  • February 2008

journal

  • Science  Journal

abstract

  • The stabilization of long-term memories requires de novo protein synthesis. How can proteins, synthesized in the soma, act on specific synapses that participate in a given memory? We studied the dynamics of newly synthesized AMPA-type glutamate receptors (AMPARs) induced with learning using transgenic mice expressing the GluR1 subunit fused to green fluorescent protein (GFP-GluR1) under control of the c-fos promoter. We found learning-associated recruitment of newly synthesized GFP-GluR1 selectively to mushroom-type spines in adult hippocampal CA1 neurons 24 hours after fear conditioning. Our results are consistent with a "synaptic tagging" model to allow activated synapses to subsequently capture newly synthesized receptor and also demonstrate a critical functional distinction in the mushroom spines with learning.

subject areas

  • Animals
  • Conditioning (Psychology)
  • Dendritic Spines
  • Doxycycline
  • Extinction, Psychological
  • Fear
  • Hippocampus
  • Learning
  • Long-Term Potentiation
  • Male
  • Memory
  • Mice
  • Mice, Transgenic
  • Protein Transport
  • Pyramidal Cells
  • Receptors, AMPA
  • Recombinant Fusion Proteins
  • Synapses
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Identity

PubMed Central ID

  • PMC2692967

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1149967

PubMed ID

  • 18292343
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Additional Document Info

start page

  • 1104

end page

  • 1107

volume

  • 319

issue

  • 5866

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