Anti-formyl peptide antibodies

Academic Article

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Overview

authors

• Tanaka, F.
• Jones, T.
• Kubitz, Diane
• Lerner, Richard

publication date

• April 2007

journal

• Bioorganic & Medicinal Chemistry Letters  Journal

abstract

• Antibodies that selectively bind to N-formylmethionyl leucyl phenylalanine (fMLF, also known as fMLP) have been generated. These antibodies bound to fMLF with higher affinity than to non-formylated peptide MLF: the differences in the binding energies between fMLF and MLF were 1.4->2.1 kcal/mol.

subject areas

• Animals
• Antibodies
• Cattle
• Chemistry, Pharmaceutical
• Drug Design
• Humans
• Immunoglobulin G
• Kinetics
• Models, Chemical
• Molecular Conformation
• N-Formylmethionine Leucyl-Phenylalanine
• Peptides
• Protein Binding
• Receptors, Formyl Peptide
• Serum Albumin, Bovine

Identity

International Standard Serial Number (ISSN)

• 0960-894X

Digital Object Identifier (DOI)

• 10.1016/j.bmcl.2007.01.082

PubMed ID

• 17293112

Additional Document Info

start page

• 1943

end page

• 1945

volume

• 17

issue

• 7