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Anti-formyl peptide antibodies

Academic Article
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Overview

authors

  • Tanaka, F.
  • Jones, T.
  • Kubitz, Diane
  • Lerner, Richard

publication date

  • April 2007

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

abstract

  • Antibodies that selectively bind to N-formylmethionyl leucyl phenylalanine (fMLF, also known as fMLP) have been generated. These antibodies bound to fMLF with higher affinity than to non-formylated peptide MLF: the differences in the binding energies between fMLF and MLF were 1.4->2.1 kcal/mol.

subject areas

  • Animals
  • Antibodies
  • Cattle
  • Chemistry, Pharmaceutical
  • Drug Design
  • Humans
  • Immunoglobulin G
  • Kinetics
  • Models, Chemical
  • Molecular Conformation
  • N-Formylmethionine Leucyl-Phenylalanine
  • Peptides
  • Protein Binding
  • Receptors, Formyl Peptide
  • Serum Albumin, Bovine
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2007.01.082

PubMed ID

  • 17293112
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Additional Document Info

start page

  • 1943

end page

  • 1945

volume

  • 17

issue

  • 7

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