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Efficient route to C-2 symmetric heterocyclic backbone modified cyclic peptides

Academic Article
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Overview

related to degree

  • Horne, William Seth, Ph.D. in Chemistry, Scripps Research 2000 - 2005

authors

  • van Maarseveen, J. H.
  • Horne, William Seth
  • Ghadiri, M. Reza

publication date

  • September 2005

journal

  • Organic Letters  Journal

abstract

  • [reaction: see text] A tandem dimerization-macrocyclization approach using 1,3-dipolar azide-alkyne cycloaddition reactions has been employed in the facile and convergent solution phase syntheses of C2 symmetric cyclic peptide scaffolds bearing triazole epsilon2-amino acids as dipeptide surrogates.

subject areas

  • Heterocyclic Compounds
  • Molecular Structure
  • Peptides, Cyclic
  • Ribavirin
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Identity

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/010518028

PubMed ID

  • 16178569
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Additional Document Info

start page

  • 4503

end page

  • 4506

volume

  • 7

issue

  • 20

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